The National Institutes of Health (NIH) Policy on the use of a single Institutional Review Board (sIRB) of record for multi-site research became effective January 25, 2018. This policy establishes the expectation that all sites participating in multi-site studies involving non-exempt human subjects research funded by the NIH will use a single Institutional Review Board (sIRB) to conduct the ethical review required by the Department of Health and Human Services regulations for the Protection of Human Subjects. This policy applies to the domestic sites of NIH-funded multi-site studies where each site will conduct the same protocol involving non-exempt human subjects research, whether supported through grants, cooperative agreements, contracts, or the NIH Intramural Research Program. It does not apply to career development, research training or fellowship awards.
This policy applies to domestic awardees and participating domestic sites. Foreign sites participating in NIH-funded, multi-site studies will not be expected to follow this policy.
Investigators are encouraged to consult with the Office of Research Integrity and Compliance (ORIC) prior to including an sIRB plan in their application if they have questions about whether or not ECU should cede IRB review to another IRB or assume the responsibility of being the IRB of record (Reviewing IRB).
You may review the NIH posting regarding sIRB review by clicking here.
If you have additional questions about the sIRB review process or IRB reliance agreements, please call the ORIC at 252-744-2914, or email your question to email@example.com.
- Changes to the federal rule governing human research (Common Rule) were announced on January 18, 2017. Many of the Common Rule changes go into effect July 19, 2018.
- The changes to the Common Rule do not apply to FDA-regulated studies.
- ORIC is working to roll out these changes at ECU. The announcements section of the ORIC > UMCIRB webpage and the ePIRATE homepage will be your main source of information and updates about the revised Common Rule roll out.
- Studies submitted on or after July 19, 2018 will be reviewed under the revised Common Rule. Currently approved studies will continue to fall under the pre-2018 Common Rule requirements.
- The revisions to the Common Rule go into effect July 19, 2018 and UMCIRB will begin reviewing new studies under the revised Common Rule on that date.
- New document templates will be posted on both the UMCIRB website and within ePIRATE. Be sure to use these new templates for any new research studies submitted on or after 07.19.18.
- Revised SOPs will be posted on the UMCIRB website.
- Existing expedited studies approved prior to January 19, 2018 will continue to follow pre-2018 requirements including required renewal at least annually. Upon request by the investigator and after discussion with ORIC, an existing study may be revised to meet the new federal requirements. An amendment would need to be submitted and approved within the electronic IRB submission system to document this transition.
- Keep our website and the ePIRATE homepage checked for continuing and updated information.
- Contact UMCIRB with any questions. You are welcome to email us at UMCIRB@ecu.edu.
- Remember, the revised Common Rule does not apply to FDA-regulated studies.
Resources for Research Participants
Brochures & Information Sheets
- Becoming a Research Volunteer: It’s Your Decision (OHRP)
- Ser Voluntario en Estudios Clinicos: Es Su Decision (OHRP)
- For Research Participants: A Guide to Incidental Findings
(Presidential Commission for the Study of Bioethical Issues)
Links Pertaining to Participation in Research
- Learn About Clinical Trials (NIH)
- NIH Clinical Research Trials and You (NIH)
- Clinical Trials Information for Patients and Caregivers (NCI)
- Clinical Trials: What Patients Need to Know (FDA)
- Clinical Research Versus Medical Treatment
- What are the Different Types of Clinical Research
- Informed Consent for Clinical Trials
- Diversity in Clinical Trial Participation
- What is an Institutional Review Board
- Research Participants (AAHRPP)
- About Research Participation (OHRP)
These resources include a series of short videos about participating in research, a printable list of questions that potential volunteers can ask researchers, and links to additional resources." - OHRP
Questions, Concerns, or Suggestions
For questions, concerns or suggestions about research, a research-related injury or questions about your rights as someone taking part in research, call the ECU Office of Research Integrity & Compliance (ORIC) Monday through Friday at 252-744-2914. If you would like to report complaint or concern about a specific research study, you may call the Director of ORIC, at 252-744-1971.