CURRICULA SECTION 7
SCHOOL OF MEDICINE
 
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James A. Hallock, Vice Chancellor for Health Sciences and Dean of the School of Medicine
Sam N. Pennington, Associate Dean for Research and Graduate Studies
Henry O. Stone, Assistant Dean for Graduate Studies

The Departments of Anatomy and Cell Biology, Biochemistry, Microbiology and Immunology, Pharmacology, and Physiology offer graduate programs for the degree of doctor of philosophy.  The Department of Pathology offers the doctor of philosophy in interdisciplinary biological sciences.  The educational objectives of these programs are to foster scholarship, critical analysis, and creative research activity in a particular field of study.  In selecting the small number of candidates for admission, the departments give careful attention to individual aptitudes and career goals and design their curricula to complement the students' baccalaureate experiences.  Each candidate is encouraged to acquire a broad understanding of human biology in both health and disease and to gain authoritative knowledge in a specific area.

Doctoral studies in the School of Medicine provide opportunities for students to have frequent contact with a wide variety of health science professionals who are concerned with problems relating to human biology.

All of the departments are excellently equipped with state-of-the-art instrumentation necessary for preparative and analytical procedures.  Specialized facilities are also available for cell and tissue culture, virological studies, and for the handling of pathogenic and recombinant agents.

Each department considers the laboratory as the major setting for the education of its doctoral candidates.  Students are encouraged to begin research activity immediately upon entering the program and are assigned to staff members who supervise them in aspects of a research problem compatible with part-time laboratory work.  Students are provided the opportunity to rotate among several faculty, within and outside of a department, before selecting a thesis preceptor.

PROGRAM REQUIREMENTS AND CURRICULUM

A minimum of 58 s.h. of course work is required for the doctoral program, of which 15-18 s.h. may be in a cognate minor area.  If fewer than 58 s.h. of course work and cognates to the major field are required in a plan, a specific statement to justify this plan should be submitted to and approved by the departmental chairperson and the dean of the Graduate School.

A doctoral student may minor in an area acceptable to the graduate faculty of the major department.  When a minor is declared, the minor department(s) will be represented on the student's advisory committee.  A formal minor consists of a minimum of 15 s.h. earned in course work or 24 s.h. of combined course work and research approved by the graduate faculty of the department(s) of the minor field.

If the candidate meets all admission requirements, most courses required of him or her will be available in the Departments of Anatomy and Cell Biology, Biochemistry, Microbiology and Immunology, Pathology, Pharmacology, and Physiology in the School of Medicine.  Upon approval of the departments concerned, individual needs of students may be met by appropriate graduate courses offered by East Carolina University and by other doctoral programs in the state of North Carolina.

Graduate work completed prior to admission to doctoral candidacy will be evaluated by the advisory committee when the individual program of study is developed.  Transfer of credit is subject to further approval by the chairperson of the major department and the dean of the Graduate School.

A student whose undergraduate transcript indicates a deficiency in departmental prerequisites will be required to undergo examination to verify competency before admission to graduate study.  If a student is admitted deficient in analytical and communicative skills necessary for his or her anticipated program, specific remediation will be prescribed in the student's individual program plan.  All such deficiencies must be removed before the doctoral candidacy examination is administered.

INDIVIDUAL PROGRAM PLANS

Student Advisory Committees. The departmental graduate committee will be responsible for designing tentative program plans for all entering students and for evaluating their performance until the individual advisory committee is established.

At the appropriate time, a four-member advisory committee for each student will be appointed by the chairperson of the department.  The committee will be chaired by the student's dissertation director.  The individual advisory committee will formulate the student's program of study and submit it for review through the departmental chairperson to the dean of the Graduate School.  In addition to formulating, administering, and evaluating the doctoral candidacy examination, the committee will have advisory responsibilities in the subsequent development of the dissertation.  This advisory committee will administer and evaluate the final dissertation examination.  The committee's evaluations and certification that the degree requirements have been

fulfilled will be forwarded through the departmental chairperson to the dean of the Graduate School and the associate dean for research and graduate studies at the School of Medicine.

Doctoral Candidacy Examination. This examination is normally taken after the major course requirements have been completed.  Upon passing this examination, the student is admitted to candidacy for the degree, doctor of philosophy.  Each candidate is examined for his or her understanding and mastery of a broad field of knowledge, not merely the formal course work completed.  The student must demonstrate abilities for critical analysis and synthesis as well as a familiarity with scholarly methods of research.  The examination of scientific material shall consist of written and oral components.  At the option of the departmental Graduate Studies Committee, a major part of the examination format may be the defense of one or more original propositions developed by the student.

The student's advisory committee, following the administration and evaluation of the candidacy examination, will forward to the dean, through the chairperson of the department, one of the following recommendations.

  1. The responses are satisfactory and the student is recommended to candidacy for the doctoral degree.
  2. Some responses are unsatisfactory and the student is to be re-examined at a specific time.  Subjects and time are to be set by the advisory committee.
  3. The responses are unsatisfactory, but a full re-examination will be administered during the subsequent semester.
  4. The responses are unsatisfactory and termination of the program is recommended.

Doctoral Dissertation. The dissertation must reflect independent, self-motivated research which contributes significant new knowledge to the candidate's major field.  The dissertation should demonstrate the candidate's skills in experimental design and technique.  It must be effectively written and demonstrate understanding of the historical foundations of the work as well as a thorough analysis of the strengths, weaknesses, and significance of the results.

Before the candidate begins dissertation research, the candidate's advisory committee must approve a proposal containing the following:

  1. A brief review of the pertinent literature.
  2. A short statement on the nature of the problem and the objectives of the proposed study.
  3. An outline of a feasible research program.

It is the responsibility of the advisory committee to counsel the student in his or her research program, criticize the dissertation, and conduct the final examination.  Upon the satisfactory completion of all requirements, the committee and departmental chairperson will recommend to the dean of the Graduate School through the associate dean for research and graduate studies at the School of Medicine, the award of the doctoral degree.

The basic form of the dissertation manuscript will follow the East Carolina University Manual of Style or a standard manual acceptable in the major field.  The East Carolina University library will bind the final copies.  The original and four copies of the final approved manuscript must be deposited in the Graduate School office.  Joyner Library will microfilm the dissertation and list the title and abstract in Dissertation Abstracts.  The charges for binding the original and four copies of the manuscript and listing the title and abstract will be covered by the School of Medicine graduate office and Joyner Library.  Copy and binding charges for additional copies will be the student's responsibility.

Enrichment.  In addition to course requirements, students are encouraged to participate in scholarly activities, such as experience as teaching assistants and involvement in university-wide seminars.  Such activities should be considered as components of the overall program of study.

As part of their predissertation course requirements, students are assigned various periods of rotation in research laboratories of individual faculty members to gain perspectives and laboratory experience in areas outside their fields of major interest.  As appropriate, assistance will also be sought from other departments of the university to meet special needs of students.  Assignment of students to individual faculty members for pre-dissertation rotations may be made by the chairperson or by the student's advisory committee.

TIME LIMITS FOR COMPLETION OF DEGREE REQUIREMENTS

A doctoral degree program must be completed before the end of the twelfth semester, excluding summers, following initial enrollment.  With endorsement of the student's advisory committee and the departmental chairperson, a student may request one extension of not more than two semesters, summers included.

PROGRAM COURSES

The courses indicated by an asterisk are required of all candidates.  Some courses carry variable hours of credit.

DEPARTMENT OF ANATOMY AND CELL BIOLOGY

Jack E. Brinn, Chairperson

ANATOMY AND CELL BIOLOGY: ANAT

6200. Gross Anatomy (8) Prerequisite: Consent of chairperson.  An overview of human anatomy based on a systematic dissection of the human body.  Related and pertinent developmental anatomy is also covered.  Lectures, laboratories, demonstrations, and conferences are designed to stress structure-function relationships.

6202. Molecular Cell Biology (4) Same as MCBI 6410.  Prerequisite: Consent of instructor.  Principles of molecular cell biology with emphasis on critical analysis of experimental data and the experimental basis of current knowledge of processes in living cells.

6210. Microscopic Anatomy (4) Prerequisite: Consent of chairperson.  The microscopic structure and fine structural features of cells, tissues, and organs are presented.  Certain developmental aspects are presented as they relate to these areas.

6215. Neurobiology (4) Prerequisite: Consent of chairperson; recommended: ANAT 6200, 6210. Encompasses  the structure and function of neurons in the human nervous system at organ, cellular, and molecular levels.  Lectures cover the synaptic and topographical relations of neurons, and the distribution and function of neurotransmitters, neurotrophic factors, and brain hormones.  The in situ relationships of the central nervous system and its covering are correlated with several diagnostic procedures, including magnetic resonance imaging.  Lectures by clinicians, video, and computerized instructional material help the student relate structure and function to clinical applications.  Laboratory sessions include dissection of the human brain and the study of prospected specimens.

6230. Developmental Biology (4) Not offered every year.  Prerequisite: Consent of chairperson; recommended: ANAT 6200, 6210.  Contemporary concepts in developmental biology.

6240, 6241, 6242. Research Problems in Anatomy and Cell Biology* (1-3) Prerequisite: Consent of chairperson.  For each course, the student is assigned to a different faculty preceptor and given the opportunity to learn the design of experimental protocols and to collaborate in some aspects of the preceptor's research program.  Two or three of the preceptorships will be required, depending on the student's background.

6250. Seminar in Anatomy and Cell Biology* (1) Students will be required to register for the course for four semesters, but only 2 s.h. will be applied toward the credit requirements for the degree.  Prerequisite: Consent of departmental chairperson.  Formal seminars and student journal club presentation focused on current topics in anatomy and cell biology. 

6290, 6291, 6292. Current Topics in Anatomy and Cell Biology (1,2,3) May be repeated more than once.  Prerequisite: Consent of chairperson.  Reading and discussion of literature in selected fields relevant to anatomy.  The format and subject matter may be tailored to the needs of an individual student or a small group of students at the discretion of the chairperson, the student's advisory committee, and a faculty member willing to direct the readings.

9000. Dissertation * (3) May be repeated. May count for a maximum of 18 s.h. toward the degree.

DEPARTMENT OF BIOCHEMISTRY

Joseph G. Cory, Chairperson

BIOCHEMISTRY: BIOC

6300. General Biochemistry* (5) Prerequisites: General chemistry; organic chemistry; general biology; calculus; consent of chairperson.  Treats the following subject areas with particular emphasis on human biochemistry: chemistry and function of enzymes and other proteins; mechanisms of energy transduction; metabolism of carbohydrates, lipids, amino acids, and proteins; biochemistry of the gene and gene expression; tissues and organ metabolism; regulation of metabolism; biochemical aspects of nutrition; and metabolism of abnormal cells.

6301. Biomolecular Structure (4) Prerequisites: Undergraduate general chemistry; organic chemistry; and consent of departmental chairperson.  Structure and physical and chemical properties of biomolecules, including an introduction to thermodynamics and kinetics of biological systems.

6305. Physical Biochemistry* (4) Prerequisites: Undergraduate physical chemistry; calculus; BIOC 6301; consent of departmental chairperson.  Application of thermodynamics and kinetics to biochemical systems.

6310. Molecular Biochemistry* (3) Prerequisites: General chemistry; organic chemistry; general biology; consent of departmental chairperson.  Replication, translation, and expression of genetic information and its regulation.

6320. Metabolism* (4) Prerequisites: General chemistry; organic chemistry; general biology; and consent of departmental chairperson.  Recommended prerequisite: BIOC 6301.  Study of the metabolism of carbohydrates, lipids, and amino acids.  Focus is on the integration of metabolism and its regulations in humans.

6330. Introduction to Research* (1-3) Prerequisite: Consent of instructor.  Each student is assigned to a faculty preceptor and is given the opportunity to learn the design of experimental protocols and to collaborate in some aspect of the preceptor's program.  The student will be required to register for the course for three semesters.

6335. Seminar in Biochemistry* (1) Prerequisite: Consent of chairperson.  Student critiques of current literature in biochemistry, concentrating on one topic each semester. Each student will be required to register for the course for six semesters, but only 2 s.h. will be applied toward the credit requirements for the degree.

6355. Current Topics (1) May be repeated more than once with change of topic.  Prerequisite: Consent of chairperson.  Topics of current importance which have not been covered thoroughly in other courses will be emphasized.  Lectures, special reports, or laboratory work.

9000. Dissertation* (3) May be repeated. May count for a maximum of 18 s.h. toward the degree.

BIOC Banked Courses

6350. Biochemistry of Disease (2)

DEPARTMENT OF COMPARATIVE MEDICINE

William H. Pryor, Jr., Chairperson

COMPARATIVE MEDICINE: CMED

6100. Animal Research Methods (2) Prerequisite: Consent of instructor.  An introduction to use of mammalian subjects in biomedical research, with emphasis on rationale for species and strain selection, ethics of animal use, regulation of animal experimentation, diseases affecting research results, surgical technique, and experimental procedures.

DEPARTMENT OF MEDICAL HUMANITIES

Loretta C. Kopelman, Chairperson

MEDICAL HUMANITIES: HUMS

6200. Ethics and Research: Humanities and Basic Medical Sciences (1) Prerequisite:  Consent of instructor.  A seminar course focusing on critical analysis of major issues in the history, ethics, and philosophy of the biomedical sciences, including bias and fraud in science, regulations for protection of human and animal research subjects, methodology of clinical trials, sociobiology, social responsibilities of scientists, and other topics.

DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY

Paul V. Phibbs, Jr., Chairperson

MICROBIOLOGY AND IMMUNOLOGY: MCBI

6400. Medical Microbiology and Immunology I (4) Prerequisites: BIOC 6300 or equivalent; consent of chairperson.  Basic concepts and principles of immunology, genetics, and virology as they pertain to medical microbiology and medicine.  Introduction to cellular and humoral aspects of the immune system and to mechanisms of host resistance to infectious disease.  Survey of medically important viruses with emphasis on biochemical anatomy, mechanisms of pathogenesis, laboratory diagnosis and methods of control and prevention of infection.

6401. Medical Microbiology and Immunology II (4) Prerequisites: BIOC 6300; MCBI 6400; or equivalent; consent of chairperson.  Basic principles of medical bacteriology, mycology, and parasitology.  Emphasis will be placed on mechanisms of pathogenesis, methods of laboratory diagnosis, and methods of control and prevention of diseases caused by these organisms.  Content will include anatomy, physiology and genetics of medically important species of bacteria, fungi, animal parasites, and laboratory exercises.

6410. Molecular Cell Biology (4) Same as ANAT 6202.  Prerequisite: Consent of instructor.  Principles of molecular cell biology with emphasis on critical analysis of experimental data and the experimental basis of current knowledge of processes in living cells.

6420. Physiology and Ultrastructure of Microorganisms I (4) Prerequisites: General microbiology and general biochemistry or consent of instructor.  Advanced topics in the chemical and physical organization of the prokaryotic organism. The relationships of structure to function, growth, metabolism, nutritional requirements, and environment. 

6440. Advanced Molecular Genetics (4) Prerequisite: MCBI 6410.  A detailed, critical presentation of the molecular structure-function relationship in the stability, dynamics, and expression of genetic information of both prokaryotic and eukaryotic cells.  State-of-the-art analytical and synthetic approaches to molecular genetic problems will be presented.

6450. Immunology (4) Prerequisites: BIOC 6300 or equivalent; MCBI 6400 or equivalent; consent of instructor.  A concise presentation of immunology, immunity, and immunopathology. Immunology will include principles of the induction and expression of specific immune responses. Immunochemical and cellular principles of immune responses. Immunity will include the role of immune reactions in infections and cancer. The immunopathology section will emphasize roles of the immune system in tissue damage and disease.

6460. Animal Virology (3) Prerequisites: MCBI 6401 or equivalent and consent of instructor.  Current topics in animal virus research will be critically examined at an advanced level.  Viral replication cycles, the effects of viral replication on host cells, viral genetics, and the design of modern viral vaccines will be included.

6480. Seminars in Microbiology and Immunology* (1) Student is required to register each fall and spring semester while a pre-candidate and may register for the course for a maximum of six semesters with a maximum of 4 s.h. to be applied toward the doctoral degree.  Prerequisite: Consent of instructor.  Program of formal seminars and student journal club presentations focused on current topics in microbiology and immunology.

6490. Topics in Microbiology and Immunology (1-4) Student may register for the course for up to four semesters with a maximum of 4 s.h. to be applied toward the doctoral degree.  Prerequisites: MCBI 6400 or equivalent and consent of departmental chairperson.  Critical presentation of topics of current importance in microbiology and immunology and focusing on a particular subdiscipline, problem, or group of organisms.

6498. Problems in Microbiology and Immunology* (1-4) Student may register for the course for up to six semesters, summer session included, with a maximum of 8 s.h. credits to be applied to the doctoral degree.  Prerequisite: Consent of departmental chairperson.  Supervised nondissertation research in microbiology or immunology.  For the first two semesters registered, the student ordinarily is assigned to a different faculty preceptor.  Two preceptorships will ordinarily be required of each doctoral student.

9000. Dissertation* (3) May be repeated. May count for a maximum of 18 s.h. toward the degree.

MCBI Banked Courses

6405. Contemporary Problems in Microbiology and Immunology (2)
6421. Physiology and Ultrastructure of Microorganisms II (4)
6425. Microbial Systematics (3)
6426. Anaerobic Bacteriology (1-3)
6451. Immunological Techniques (3)
6452. The Lymphocyte (3)
6453. Hybridoma Technology (2)
6461. Diagnostic Virology (2)
6462. Molecular Virology Laboratory (3-5)
6470. Internships in Microbiology and Immunology (2-6)

DEPARTMENT OF PATHOLOGY

Peter Kragel, Chairperson

PATHOLOGY: PATH

6800. Principles of Pathology (4) Prerequisite: Consent of course director.  Treats the following subject areas: Cell injury, cell death, acute inflammation, chronic inflammation, regeneration and repair, pigments and mineralization, thrombosis and infarction, teratogenesis and oncogenesis, etiogenesis of cancer, genetic disease, auto-immune disease, bacterial disease, and nutritional disease.

6801. Systemic Pathology (8)  Prerequisites: PATH 6800 and consent of course director.  Pathology involving the following systems is discussed: cardiovascular system, hematopathology, respiratory system, gastrointestinal system, including liver and pancreas, kidney, reproductive pathology, endocrinology, nervous system, skin and musculoskeletal system.

6805. Contemporary Pathobiology (2) May be repeated more than once.  Prerequisite or corequisite: PATH 6800 and consent of instructor.  Major emphasis on the study of disease processes from ultrastructural, developmental, immunological, cellular, and molecular points of view. Illustrative examples of experimental models and molecular aspects of disease processes will be presented.

6810. Methods and Techniques in Experimental Pathology (3) May be repeated more than once.  Prerequisite: Consent of course director.  Each entering student will rotate for approximately one month through each of the research laboratories supervised by a member of the departmental faculty; the student will focus on a single technique in each research laboratory.

6815. Seminar in Pathology (1) May be repeated more than once.  Each PhD candidate will register for the course for 6 semesters.  Prerequisite: Consent of course director.  Student critiques of current literature in pathology concentrating on one topic each semester.  Each student registered for the course will be required to present a seminar. 

6820. Current Topics in Pathology Research (2) May be repeated more than once.  Prerequisite: Consent of course director.  Topics of current importance reflecting the newest scientific development. 

6830. Introduction to Research (1-5) May be repeated more than once.  Prerequisite: Consent of instructor.  During the second year of graduate school, each student is assigned to a faculty preceptor and is given the opportunity to learn the design of experimental protocols and to collaborate in some aspect of the preceptor's research program.

9000. Dissertation* (3) May be repeated. May count for a maximum of 18 s.h. toward the degree.

DEPARTMENT OF PHARMACOLOGY

Wallace R. Wooles, Chairperson

PHARMACOLOGY: PHAR

6600. Medical Pharmacology* (5) Prerequisites: PHLY 6700; BIOC 6300;  consent of chairperson.  Includes all the general principles of pharmacology and toxicology. The mechanism(s) of action, pharmacokinetics, toxicity and the rationale for use of each major class of drugs will be presented. In addition to the toxicity of each drug, toxicology will be a major component of the course.

6605. Seminar* (1) May be taken more than one semester.  Prerequisite: Consent of chairperson.  Formal presentation and exchange of research ideas by faculty, distinguished guest speakers, and students.

6609. Introduction to Pharmacology* (3) Prerequisites: Previous admission to the graduate program in biomedical sciences in the School of Medicine and concurrent registration in graduate biochemistry and physiology; consent of chairperson.  Introductory pharmacology for students enrolled in PhD programs in the biomedical sciences.  History and scope of pharmacology; quantitative principles of uptake, distribution, biotransformation and elimination of drugs; dose and time-response relationships, pharmacokinetics and factors modifying drug actions.

6610. Basic Mechanisms of Drug Action* (3) Prerequisites: PHLY 6700; BIOC 6300; or equivalent; consent of chairperson.  Fundamental mechanisms by which drugs affect the physiology and biochemistry of living systems, at macromolecular, cellular, organ, systemic, and multisystemic levels.

6615. Research Procedures* (2) May be taken more than one semester.  Prerequisite: Consent of chairperson.  Students are assigned to faculty preceptors to learn the design of experimental protocol and to collaborate in some aspect of the preceptor's program. This precedes the beginning of thesis research.

6640. Pharmacology of the Central Nervous System (3) Prerequisites: BIOC 6300; PHLY 6700; consent of chairperson.  Basic neuropharmacological principles, theories dealing with the mechanisms of action of CNS drugs, psychological and sociological basis of drug abuse.

6660. Cardiovascular Pharmacology (3) Provides the student with a thorough understanding of the effects of drugs on the heart and blood vessels through laboratory work, directed readings, and seminars.

6670. Research Techniques (3) Prerequisites: BIOC 6300 or equivalent; PHAR 6609 or equivalent; or consent of course director. Advanced laboratory techniques used in biomedical research. Examples include molecular cloning, protein methods, equilibrium binding analysis, enzyme assays, microscopy, isolated tissue preparations, anesthesia, stereotaxic surgery, and behavioral paradigms. Each laboratory is preceded by a lecture covering the relevant material.

9000. Dissertation (3)  May be repeated. May count a maximum 3 s.h. toward the degree.

PHAR Banked Courses

6650. Advanced Topics in Pharmacology (2)
6655. Pharmacological Regulation and Identification of Receptors (3)

DEPARTMENT OF PHYSIOLOGY

Robert M. Lust, Chairperson, 6N-98 Brody

NEUROSCIENCE: NEUR

5000. Cellular and Molecular Neuroscience (3) Prerequisite: Senior or graduate standing and consent of instructor. Introduction to the cellular mechanisms and molecular basis of neuron and glial function and interaction. Topics include membrane trafficking, action potentials, receptors and signal transduction, gene transcription factors, neuroimmunology, and developmental neuroscience.

5001. Behavioral and Integrative Neuroscience (3) Prerequisite: Senior or graduate standing and consent of instructor. Introduction to the neural systems and the neural basis of behavior. Topics include basic neuroanatomy, computational neuroscience, learning and memory, sensory and motor systems, neural basis or affective behavior, consciousness and cognitive neuroscience, neural plasticity, and brain lateralization and language.

PHYSIOLOGY: PHLY

6700. Medical Physiology* (8) Prerequisite: Consent of chairperson.  Provides a foundation in the principles of normal function of the human body with particular emphasis on human physiology. The basic physiological processes in health are dealt with through lectures, conferences, demonstrations, and experimental laboratory sessions, with special emphasis being given to the integrated nature of organ system function.

6701. Graduate Cellular Physiology (4) Prerequisites: BIOC 6300 or equivalent; PHLY 6700 or equivalent; consent of department chair. Advanced study of cell function, growth, and differentiation. Focus on mechanisms underlying transport, motility, secretion; signal transduction; proliferation and differentiation.

6702. Graduate Organ Systems Physiology (4) Prerequisites: BIOC 6300 or equivalent; PHLY 6700 or equivalent; consent of department chair. Advanced study of the integrated function of the cardiovascular, respiratory, renal and endocrine systems with emphasis on normal physiological process and how selected pathologies alter organ system function.

6705. Cardiovascular Physiology (3) Prerequisites: PHLY 6700; or 6701, 6702; consent of chairperson.  Instrumentation and techniques, evolutionary and developmental aspects of the heart, dynamics and control of the body fluids, integration and regulatory aspects of reflex control of the circulation, systems analysis of the circulation, exercise physiology, and the pathophysiology of congestive heart failure and hypertension.

6710. Advanced Topics in Physiology* (2) May be repeated more than once.  Prerequisites: PHLY 6700 and consent of chairperson.  A study of selected research topics within the field of physiology.

6715. Seminar* (1) May be repeated more than once.  Prerequisites: PHLY 6700; or 6701, 6702; consent of chairperson.  Selected topics of current interest.

6720. Respiratory Physiology (2)  Prerequisites: PHLY 6700; or 6701, 6702; consent of chairperson.  Presentation of selected topics in the field of respiration. Areas of emphasis may include lung mechanics, clinical tests, surfactants, blood gases, acid-base chemistry, and the pathophysiology of the lung.

6725. Membrane Transport Processes (2)  Prerequisites: Calculus; physical chemistry; consent of chairperson.  A critical survey of current theories of electrolyte and non-electrolyte transport processes at the cellular and organ level.

6730. Cellular Neurophysiology* (3) Prerequisites: Calculus; physical chemistry; consent of chairperson.  Development of theoretical and experimental evidence underlying modern concepts of bioelectric phenomena.  Current concepts of membrane structure, metabolism, resting and action potentials, ionic fluxes, and techniques utilized in electrophysiological research. Seminars, with emphasis on the critical evaluation of pertinent original research papers.

6733. Sensory Systems Neurophysiology (3) Prerequisites: PHLY 6700; or 6701, 6702; consent of chairperson.  Basic principles of the functional organization of somatic and special sensory systems, with emphasis on synaptic processing of sensory information.

6735. Renal, Acid-Base Physiology (2) Prerequisites: PHLY 6700; or 6701, 6702; BIOC 6300; consent of chairperson.  Presentation of selected topics in the field of renal physiology and acid-base chemistry.

6738. Special Topics in Endocrinology (2) May be repeated more than once.  Prerequisites: PHLY 6700; or 6701, 6702; BIOC 6300; consent of chairperson.  Presentation of selected topics in the field of endocrinology. Areas of emphasis may include adrenal, reproductive, pituitary or thyroid physiology. Includes lectures and a formal presentation of a seminar by each student.

6740. Introduction to Research* (3) May be repeated more than once.  Prerequisite: Consent of chairperson.  Collaborative or independent research in a variety of physiology specialty areas including research in preparation for the doctoral dissertation.

9000. Dissertation (3) May be repeated. May count a maximum of 18 s.h. toward the degree.

PHLY Banked Courses

6050. Human Physiology for Advanced Nursing Practice (3)

DEPARTMENT OF RADIATION ONCOLOGY

Hyder H. Arastu, Interim Chairperson, 167 Leo W. Jenkins Cancer Center

RADIATION ONCOLOGY: RONC

5370. Biological Effects of Radiation (3) Same as BIOL 5370. Prerequisites: BIOL 1100, 1101, 1200, 1201; or consent of instructor.  A survey of the biological effects resulting from the interactions of radiation and matter for scientifically- and technically-oriented students. 

6718. Therapeutic Radiological Physics (3) Same as PHYS 6718.  Prerequisite: Consent of departmental chairperson.  A detailed study of the production, application, and measurement of electromagnetic radiation and high energy particle beams in therapeutic practice, with emphasis on conceptual, instrumental, and methodological aspects of therapeutic radiology.

6992. Radiation Therapy Physics (3) Same as PHYS 6992.  Prerequisite: PHYS 6718 or RONC 6718.  Study of radiation dose calculation and measurement of high energy photon and electron beams, high and low dose rate brachytherapy sources in clinical radiation therapy, cavity theory in ion chamber calibrations of photon and electron beams.  Quality assurance, acceptance testing and commissioning of equipment for clinical radiation therapy (linear accelerators, HDR, TLD, simulator, CT scanner.

6993. Clinical and Medical Dosimetry (2) Same as PHYS 6993.  Prerequisite: PHYS 6992 or RONC 6992.  Practical patient dosimetry problems in radiation oncology including irregular field calculations, two-and three-dimensional treatment planning, isodose distribution, high and low dose rate brachytherapy planning for intracavitary and interstitial radioactive sources.

INTERDEPARTMENTAL

INTERDEPARTMENTAL: INTE

6200. Statistics and Computing for Biomedical Research (3,3) Two one-hour lectures and one three-hour laboratory per week.  Prerequisite: BS in a science discipline or consent of instructor.  A study of key statistical methods combined with hands-on experience in the utilization of computer-based tools.  Such topics as laboratory data acquisition, data summarization, graphical display, computer interfacing, and the use of SAS, SPSS, BMDP, and STATPAK for data management and statistical analysis will be included.


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