attack or myocardial infarction affects more than 720,000 Americans every year.
Since the heart lacks a sufficient regenerative capacity to repair the injury,
irreversible cardiomyocyte death occurs, ultimately leading to
heart failure. With more than $108.9 billion in costs associated with heart
disease compounded by decreased quality of life and longevity, finding
mechanisms that can preserve heart cells is imperative for reducing financial
costs and improving patient health.
Dr. Jitka Virag and her co-investigators from the Department of Physiology from the Brody School of Medicine have developed a novel method to preserve heart tissue viability following myocardial infarction. Ephrin A1 is delivered to the heart following myocardial infarction. Ephrin A1 delivery preserves heart tissue by reducing infarct size, necrosis, wall thinning and inflammatory cell infiltration.
Augustin DuSablon, Susan Kent, Anita Coburn, and Jitka
Virag.EphA2-Receptor Deficiency Exacerbates Myocardial Infarction and Reduces
Survival in Hyperglycemic Mice. Cardiovascular Diabetology 2014, August 13:114. PMID: 2516650
O'Neal, WT, Griffin, WF, Kent, SD, Faiz, F,
Hodges, J, Vuncannon,
J, and Virag, JAI. Deletion of the EphA2 receptor exacerbates myocardial injury
and the progression of ischemic cardiomyopathy. Frontiers in Physiology,
Integrative Physiology 2014 Mar 17, 5: 132. PMID: 24795639
Protein Could Help Save Tissue Following Heart Attack