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installing gamma knife
WNCT Channel 9 reporter Laura Barron interviews Dr. Marcus Randall, as a crew rolls the Leo W. Jenkins Cancer Center‰s gamma knife radiation unit into its new home on the medical campus. (Photo by Doug Boyd)

Jenkins Center Installs Tool to Treat Brain Tumors

By Doug Boyd

Equipped with a crane, jacks and dollies, crews on July 19 installed the 20-ton heart of what will be a new tool in the Leo W. Jenkins Cancer Center‰s fight against brain tumors.

The device is the Leksell Gamma Knife, though it‰s not actually a knife. It uses gamma rays to allow radiation oncologists and neurosurgeons to treat brain tumors, lesions, blood vessel malformations and other problems of the brain without making an incision. The Gamma Knife uses a single dose of radiation, directed simultaneously through 201 ports in a special device patients wear on their heads, to specific targets within the brain. The beams intersect at the tumor or other target and destroy abnormal tissue while leaving normal tissue intact.

Dr. Marcus Randall, director of the Leo W. Jenkins Cancer Center and professor of radiation oncology at ECU‰s Brody School of Medicine, will serve as radiation oncology co-director of the Gamma Knife program. Dr. Barbara Lazio of Eastern Neurosurgical and Spine Associates will serve as surgical co-director. Both have previous experience working with the devices.

,It gives us the capability to treat some patients that in the past we couldn‰t treat here,Š Randall said. ,And for some patients we might have treated before, it gives us a better way to treat them.Š

Several patients have already been identified as candidates for treatment with the device, which should go into service in October.
Officials last year approved a plan by Pitt County Memorial Hospital to buy and install the device, only the second one in the state. The other is at Wake Forest University in Winston-Salem. PCMH has built a 2,800-square-foot addition to the magnetic resonance imaging facility on the property of the medical school to house the Gamma Knife. PCMH is leasing the land and facility from ECU.

Total cost is estimated to be nearly $5.6 million, with about $3.7 million of that going for the Gamma Knife itself. PCMH is footing the bill.

Physicians must be trained and credentialed to use the Gamma Knife. The third member of the team that will conduct procedures, along with the neurosurgeon and radiation oncologist, will be an ECU radiation physicist, who is also trained and credentialed.

,Currently all ECU (radiation oncologists) are treating with stereotactic radiosurgery, and the Gamma Knife is an extension of this technique,Š said Dr. Ron Allison, chairman of the Department of Radiation Oncology. ,We are able to go directly into Gamma Knife radiosurgery without much trouble as we have been offering this service for (three) years.Š

Gamma Knife surgery is generally an outpatient procedure with patients staying fewer than 24 hours in the hospital. Patients are usually able to resume normal activities within 48 hours. The total procedure itself, which also requires patients to undergo a magnetic resonance imaging test, generally takes two to three hours, according to Randall.

Traditional brain surgery requires about a week in the hospital and six to eight weeks of recovery.

,This certainly won‰t replace brain surgery,Š Randall said. ,In some cases, that‰s still a better treatment.Š

The Gamma Knife has no moving parts during treatment, which improves safety, accuracy, reliability and reproducibility. Because of its accuracy, the device allows doctors to treat tumors previously thought inoperable, including tumors near the brainstem, cranial nerves and optic apparatus.

The procedure is also effective for lesions not completely removed by previous surgery and for tumors that recur after surgery or radiation therapy.

As with any radiation treatment, results are not immediate. Treatment stops the growth of tumors and lesions, and their size should decrease over time.

,It‰s exciting to treat these patients and watch how well they do,Š Randall said. He said the program aims to treat approximately 90 patients in its first year of operation.

Swedish neurosurgeon Lars Leksell and physicist Borje Larsson developed the Gamma Knife and related technology. Since 1968, doctors have used them to treat more than 180,000 patients worldwide. Twenty percent of these patients were treated for vascular malformations. Within three years of treatment, approximately 85 percent of these patients‰ abnormalities were cured.

For people suffering from Cushing‰s Disease, a disorder of the pituitary gland, the Gamma Knife has proven to be the most effective treatment option, with a success rate of 80 percent. Clinical research is ongoing in treating Parkinson‰s Disease and other movement disorders, epilepsy and chronic pain associated with cancer.

This page originally appeared in the Sept. 2, 2005 issue of Pieces of Eight. Complete issue is archived at http://www.ecu.edu/news/poe/archives.cfm.