Dr. Anthony Capehart
Area of Study: Developmental Biology
Office: Howell C-407
Address: Department of Biology
East Carolina University
Greenville, NC 27858
Ph.D. Wake Forest University - Bowman Gray School of Medicine, Anatomy
M.S. University of North Carolina - Wilmington, Marine Biology
B.A. University of North Carolina - Chapel Hill, English
Cell/Extracellular Matrix Interactions During Embryonic Development: Our lab is currently investigating the role of the matrix chondroitin sulfate proteoglycan, versican, during formation of the skeletal template and synovial joints in the embryonic limb. Using a variety of constructs to knock down expression or over-express specific domains and isoforms of versican we hope to ascertain its function during early development of the appendicular skeleton.
Nagchowdhuri P.S., Andrews K.N., Robart S., Capehart A.A. (2012) Versican knockdown reduces interzone area during early stages of chick synovial joint development. Anatomical Record, 295: 397-409.
Pugh A.M., Silvestri B.A., Ward M.A., Whited W.M., Capehart A.A. (2010). Unusual bilateral muscular variation in the medial forearm: Separate humeral and ulnar bellies of flexor carpi ulnaris and anomalous muscle addition. Anatomy, 4: 67-71.
Hudson K.S., Andrews K., Early J., Mjaatvedt C.H., Capehart, A.A. (2010). Versican G1 domain and V3 isoform overexpression results in increased chondrogenesis in the developing chick limb in ovo. Anatomical Record, 293: 1669-1678.
Capehart, A.A. (2010). Proteolytic cleavage of versican during limb joint development. Anatomical Record, 293: 208-214.
Shepard, J. B., Gliga, D. A., Morrow, A. P., Hoffman, S., & Capehart, A. A. (2008). Versican knock-down compromises chondrogenesis in the embryonic chick limb. Anatomical Record, 291 (1): 19-27.
Cronin, K. D. & Capehart, A. A. (2007). Gamma protocadherin expression in the embryonic chick nervous system. International Journal of Biological Sciences, 3 (1): 8-11.
Shepard, J. B., Krug, H. A., LaFoon, B. A., Hoffman, S., & Capehart, A. A. (2007). Versican expression during synovial joint morphogenesis. International Journal of Biological Sciences, 3 (6): 380-384.
Williams, D. R., Presar, A. R., Richmond, A. T., Mjaatvedt, C. H., Hoffman, S., A.A. Capehart, (2005). Limb chondrogenesis is compromised in the versican deficient hdf mouse. Biochemical and Biophysical Research Communications, 334: 960-966.
Snow, H. E., Riccio, L. M., Mjaatvedt, C. H. , Hoffman, S., & Capehart, A. A. (2005). Versican expression during skeletal/joint morphogenesis and patterning of muscle and nerve in the embryonic mouse limb. Anatomical Record, 282A: 95-105.
BIOL 4060, 4061. Embryology.
BIOL 4071, 6071. Human Gross Anatomy.
BIOL 7090, 7091. Experimental Embryology.
BIOL 2130, 2140, 2150 Human Physiology and Anatomy.