Feldbush, Thomas 

Education

      1966           Ph.D.                      Ohio State University, Columbus,    

      1964           M.S.                       Ohio State University, Columbus,

Post-Graduate Education

      1969-1970                                 Visiting Worker

                                                Sir William Dunn School of Pathology, Oxford, England (with Professor James L. Gowans, Medical Research Council Cellular Immunology Unit)

Financial Resources (Grants and Contracts)

      A)   Federal

NIH.  Antigen Modulation of Immunologic Memory; 9/1/72-8/31/75; $55,779

VA Medical Center.  Antigen Modulation of Immunologic Memory; 7/1/71-6/30/76; $87,300

NIH.  Immunologic Memory in the IgA Immune Systems of Rats; Drs. Butler and Feldbush; 6/15/74-8/31/77; $100,837

NIH.  Immunologic Aspects of Prostatic Cancer; Drs. Bonney, Feldbush and Lubaroff; 5/1/75-4/30/78; $75,471

VA Medical Center,  Immunologic Aspects of Prostatic Cancer, Drs. Bonney, Feldbush, and Lubaroff; 7/1/75-6/30/78; $75,000

VA Medical Center.  Selective Antigen Triggering of Memory Cells; 7/1/76-6/30/79; $95,000.

VA Medical Center.  Immunologic Aspects of Prostatic Cancer (Collaboration with Drs. D. Lubaroff and W. Bonney); 9/1/78-8/31/81; $120,000.

NIH.  Immunologic Aspects of Prostatic Cancer (Collaboration with Drs. D. Lubaroff and W. Bonney); 9/1/78-8/31/81;   $105,000.

NIH.  In Vitro Evaluation of CMI in Tumor Patients; 7/1/79-6/30/82; $90,000.

VA Medical Center.  Characterization of Memory B Cell Subpopulations:  Young versus Old Animals; 10/1/79-9/30/82; $110,000.

VA Medical Center.  Career Scientist Award; Salary Award for entire academic career.  1979-1990.

VA Medical Center.

      A.  Differential Stimulation of Memory B Cells, and

      B.  Effect of Complement Components of B Cell Stimulation. 

      1982-1986; $320,000.

NIH.  Cancer Center:  Hybridoma and Tissue Culture Core Facilities.  1981-1984; $320,000.

NIH.  Diabetes Endocrinology Research Center:  Monoclonal Antibody Core.   Grant #AM25295-06.  1984-1987; $78,000.  1987-1992; $320,000.

American Heart Association. Cyclosporin A:  Differential Effects on Immunity. Grant #84-934.  1984-1987; $99,000

Army Medical Research Council.  Immunologic Effects of Tricothecenes. 1985-1986; $42,000.

VA Medical Center.

      A.  Antigen and Mitogen Triggered Memory B Cell Responses, and

      B.  Unique Models of Virgin Rat B Cell Regulation.

      1986-1989; $339,000.

NIH.  PPG:  Regulation of the Circulation in Pathological States:  Monoclonal Antibody Core, PI: T.L. Feldbush.  1987-1992; $225,000.

VA Medical Center.

      Late Events in B-Cell Responses:  Expression of Alkaline Phosphatase.  1989-1992; $319,000.

Dept. of Energy.  Production of Radiolabeled Monoclonal Antibody Conjugates by Photoaffinity Labeling.  Grant #96.  1989-1992; $502,974.

      B.   State

Iowa Heart Association.  Enhancement and Suppression of Immunologic, 7/1/72-6/30/74; $11,722.

Iowa Thoracic Association.  Antigen Modulation of Immunologic Memory; 7/1/72-6/30/74; $5,000.

Iowa Heart Association.  Effective of Lymphoid Tissue Microenvironment; 7/1/74-6/30/75; $3,750.

Bibliography

      Papers published

      Hacker, B., and T. L. Feldbush.  1969.  N⁶-(_²-Isopentenyl)adenosine - Effects upon nucleic acid synthesis in lymphocytes in vitro and the development of immunological hypersensitivity in vivo.  Biochem. Pharmacol. 18:847-853.

      Feldbush, T. L., and T. A. Maag.  1969.  Passive transfer of resistance of Marek's disease.  Avian Diseases 13:677-680.

      Feldbush, T. L., and M. Hichens.  1970.  An acute allergic inflammation in the rat.  J. Pathol. 101:109-118.

      Hacker, B., and T. L. Feldbush.  1969.  Studies on the immunosuppressive activity of N⁶-(_-Isopentenyl) adenosine.  Proc. Amer. Assoc. Cancer Res. 10:34.

      Hacker, B. and T. L. Feldbush.  1971.  Effects of isopentenyl adenosine and phytohemagglutinin upon RNA synthesis in lymphocytes.  Cancer 27:1384-1387.

      Feldbush, T. L.,and J. L. Gowans.  1971.  Antigen modulation of the immune response: The effect of delayed challenge on the affinity of anti-DNP-BGG antibody produced in adoptive recipients.  J. Exptl. Med. 134:1453-1465.

      Burg, R. W., T. Feldbush, C. A. Morris, and T. A. Maag.  1971.  Depression of thymus and bursa dependent immune systems in chicks with Marek's disease.  Avian Diseases 15:662-671.

      Feldbush, T. L.  1973.  Antigen modulation of the immune response II.  The decline of immunologic memory in the absence of continuing antigenic stimulation.  Cell. Immunol. 8:435-444.

      Hoffmann, L. G., and T. L. Feldbush.  1973.  A model for the loss of memory potential assuming a requirement for two interacting cell populations with different functional half-lives.  Cell. Immunol.  8:445-447.

      Feldbush, T. L., and W. W. Bonney.  1937.  Graft-versus-host reaction in the rat popliteal lymph node.  Transplantation 15:215-220.

      Feldbush, T. L., I. Lande, B. Bryan, and E. O'Neil.  1974.  Antigen Modulation of the immune response.  III. Evaluation of the hypothetical short-lived memory cell.  Cell. Immunol. 12:429-442.