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Department of Biology

Name: Paul Hager
Title: Teaching Assistant Professor
Area of Study: Molecular Biology
Phone: 252-328-1848
Fax: 252-328-4178
Office: Howell S-404
Address: Department of Biology
  East Carolina University
  Greenville, NC 27858

Paul Hager

Educational Background

B.S. in Chemistry, Western Washington State University, 1976

Ph.D. in Biochemistry, University of California, Berkeley, 1984

Post-doc, University of California, San Francisco with Herb Boyer.

Research Program           

I am interested in protein expression, structure and function in a variety of organisms. In Pseduomonas aeruginosa I study the expression and regulation of genes involved in carbohydrate metabolism with a particular emphasis on understanding the control exerted by the gene crc.

Courses Taught

BIOL 3310, 3311. Cell physiology and lab.

BIOL 3221. Microbiology lab.

BIOL 5800, 5810, 5821. Biochemistry I, II and lab.

BIOL 6250, 6251. Protein Purification lecture and lab.

Recent Publications

Effect of vfr mutation on global gene expression and catabolite repression control of Pseudomonas aeruginosa. Suh, S. J., L. J. Runyen-Janecky, T. C. Maleniak, P. W. Hager, C. H. MacGregor, N. A. Zielinski-Mozny, P. V. Phibbs,Jr, and S. E. H. West.  Microbiol. (2002) 148:1571-1579.

Characterization of the 2-ketogluconate utilization operon in Pseudomonas aeruginosa PAO1. Swanson, B. L., P. W. Hager, P. V. Phibbs,Jr, U. Ochsner, M. L. Vasil, and A. N. Hamood.Mol. Microbiol. (2000) 37:561-573.

The Pseudomonas aeruginosa devB/SOL homolog, pgl, is a member of the hex regulon and encodes a 6-phosphogluconolactonase.  Hager, P. W., M. W. Calfee, and P. V. Phibbs.   J. Bacteriol. (2000) 182: 3934-41

Crc is involved in catabolite repression control of the bkd operon of Pseudomonas putida and Pseudomonas aeruginosa. Hester, K. L., J. Lehman, F. Najar, L. Song, B. A. Roe, C. H. MacGregor, P. W. Hager, P. V. Phibbs, and J. R. Sokatch. J. Bacteriol. (2000) 182:1144-1149

The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa. O'Toole, G. A., K. A. Gibbs, P. W. Hager, P. V. Phibbs,Jr., and R. KolterJ. Bacteriol. (2000) 182:425-431.

Related Activities

I formed Chirazyme Labs Inc., a biotechnology company specializing in the sale of the enzyme Chloroperoxidase, in 2006 and currently serve as CEO.