Dr. McConnell's Web Page

INSTITUTIONAL ADDRESS:
Biology Department (1990-present)

East Carolina University

Greenville, NC 27858-4353

Phone: (252) 328-4244

Fax: (252) 328-4178

E-mail:mcconnellt@ecu.edu

ADJUNCT POSITION:

Department of Microbiology and Immunology

East Carolina University School of Medicine

Brody Building

Greenville, NC 27858-4354

EDUCATION:
1980-1986, Ph.D. Immunology

Department of Pathology, University of Florida Medical Center, Gainesville, Florida 32610

1976-1979, B.S. Zoology

Department of Zoology, University of Florida, Gainesville, Florida 32611

RERERRED PUBLICATIONS:

Thankappan A, Fuller JR, Godwin UB, Kearse KP, and McConnell TJ. Characterization of glycans on major histocompatibility complex class II molecules in channel catfish, Ictalurus punctatus. Dev. Comp. Immunol.  In press, 2006

Mannie, MD, McConnell TJ, Xie, C, Li Y. Activation-dependent phases of T cells distinguished by use of optical tweezers and near infrared Raman spectroscopy. J. Immunol. Methods 297: 53-60, 2005.

Roney KE, Cuthbertson BJ, Godwin UB, Kazianis S, Della Coletta L, Rosenthal GG, Ryan MJ, Schmidt M, and McConnell TJ. Alternative splicing of major histocompatibility complex class II DXB transcripts in Xiphophorus fishes. Immunogenetics 56: 462-466, 2004.

Fuller JR, Pitzer JE, Godwin U, Albertino M, Machon BD, Kearse KP, and McConnell TJ. "Characterization of the molecular chaperone calnexin in the channel catfish, Ictalurus punctatus, and its association with MHC class II molecules. Dev. Comp. Immunol. 28:603-617, 2004. 

Mannie MD, Fraser DJ, and McConnell TJ. IL-4 responsive CD4⁺ T cells specific for myelin basic protein: IL-2 confers a prolonged postactivation refractory phase. Immunology and Cell Biology 81: 8-19, 2003.

Schmidt M, McConnell TJ, and Hoffman DR. Immunologic characterization of the recombinant fire ant venom allergen Sol I 3. Allergy 58: 342-349, 2003.

Norris MS, McConnell TJ, and Mannie MD. Interleukin-2 promotes antigenic reactivityof rested T cells but prolongs the postactivational refractory phase of activated T cells. Cell. Immunol. 211: 51-60, 2001.

Godwin UB, Flores M, Wilson MR, Quiniou S, Miller NW, Clem LW, and McConnell TJ.  MHC class II A genes in the channel catfish (Ictalurus punctatus). Dev. Comp. Immunol. 24: 609-622, 2000.

Hogan RJ, Waldbeiser GC, Goudie CA, Antao A, Godwin UB, Wilson MR, Miller NW, Clem LW, McConnell TJ, Wolters WR, and Chincha, VG.  Molecular and immunologic characterization of gynogenetic channel catfish (Ictalurus punctatus).  Marine Biotech. 1: 317-327, 1999.

Anato, AB, Chinchar VG, McConnell TJ, Miller NW, Clem LW, and Wilson MR. MHC class I genes of the channel catfish: sequence analysis and expression. Immunogenetics 49: 303-311, 1999.

McConnell TJ, Godwin UB, and Cuthbertson BJ. Expressed major histocompatibility complex class II loci in fishes. Immunological Reviews 166: 294-300, 1998.

McConnell TJ, Godwin UB, Norton SF, Nairn RS, Kazianis S, and Morizot DC. Identification and mapping of two divergent, unlinked major histocompatibility complex class II B genes in Xiphophorus fishes. Genetics 149: 1921-1934, 1998.

Criscitiello MF, Benedetto R, Anato A, Wilson MR, Chinchar VG, Miller NW, Clem LW, and McConnell TJ. B2-microglobulin of Ictalurid catfishes. Immunogenetics 48: 339-343, 1998.

Johnson BD, Nardella JP, McConnell TJ, and  Mannie MD. Acquired resistance to experimental  autoimmune encephalomyelitis is independent of V beta usage. Cellular Immunology 179: 55-65, 1997.

Godwin UB, Antao A, Wilson MR, Chinchar VG, Miller NW, Clem LW, and McConnell TJ. MHC class II B genes in the channel catfish (Ictalurus punctatus). Dev. And Comp. Immunol. 21: 13-23, 1997.

Mannie MD, White GA, Lake KR, Nardella JP, Marinakis CA, and McConnell TJ. T-helper lymphocytes specific for a myelin basic protein: low density activation prolongs a postactivation refractory phase marked by decreased pathogenicity and enhanced sensitivity to anergy. Cell. Immunol. 172: 108-117, 1996.

Schmidt M, McConnell TJ, and Hoffman DR Production of a recombinant imported fire ant venom allergen, Sol i 2, in native and immunoreactive form. J. Allergy Clin. Immunol. 98: 82-88, 1996.

Hardee JJ, Godwin U, Benedetto R., and McConnell TJ. Major Histocompatibility complex class II A gene polymorphism in the striped bass. Immunogenetics 41: 229-238, 1995.

Walker RB and McConnell TJ. Polymorphism of the MhcMosa class II b chain-encoding gene in the striped bass (Morone saxatilis). Dev. Comp. Immunol. 4: 325-342, 1994.

Mannie MD, Morrison-Plummer J, and McConnell TJ. Differentiation of Encephalitogenic T Cells Confers Resistance to an Inhibitory anti-CD4 Monoclonal Antibody. J. Immunology 151: 7293-7306, 1993.

Schmidt M, Walker RB, Hoffman DR, and McConnell TJ. Nucleotide Sequence of cDNA Encoding the Fire Ant Venom Protein Sol i II. FEBS Letters 319: 138-140, 1993.

Ezquerra A, Wilde DB, McConnell TJ, Sturmhofel K., Valas RB, Shevach EM, and Coligan JE. Mouse Autoreactive g/d T Cells II. Molecular Characterization of the T Cell Receptor. Eur. J. Immunol. 22: 491-498, 1992.

Ezquerra A, Cron R, McConnell TJ, Valas RB, Bluestone J, and Coligan JE. T Cell Receptor d-gene Expression and Diversity in the Mouse Spleen. J. Immunology 145: 1311-1317, 1990.

McConnell TJ, Yokoyama WM, Kikuchi GE, Einhorn GP, Stingl G, Shevach EM, and Coligan JE. Delta Chains of Dendritic Epidermal T Cell Receptors are Diverse, but Pair with g Chains in a Restricted Manner. J. Immunol. 142: 2924-2931, 1989.

Koning F, Yokoyama WM, Maloy WM, Stingl G, McConnell TJ, Cohen DI, Shevach EM, and Coligan JE. Expression of Cg4 T Cell Receptors and Lack of Isotype Exclusion by Dendritic Epidermal T Cell Lines. J. Immunology 141: 2057-2062, 1989.

McConnell TJ, Talbot WS, McIndoe RA, and Wakeland EK. The Origin of MHC Class II Gene Polymorphism within the Genus Mus. Nature 332:651-654, 1988.

Falus A, Wakeland EK, McConnell TJ, Gitlin J, Whitehead AS, and Coulten HR. DNA Polymorphism of MHC III Genes in Inbred and Wild Mouse Strains. Immunogenetics 25: 290, 1987.

McConnell TJ, Darby B, and Wakeland EK. Restriction Fragment Length Polymorphisms of Class II Gene Sequences in Mice Expressing Minor Structural Variants of I-Ak and I-Ap. J. Immunology 136: 3076, 1986.

Elder M, Maclaren NK, Riley WJ, and McConnell TJ. Gastric Parietal Cell and Other Autoantibodies in the BB Rat. Diabetes 31: 313, 1982.

Riley WJ, McConnell TJ, Maclaren NK, McLaughlin JV, and Taylor G. The Diabetogenic Effects of Streptozotocin in Mice are Prolonged and Inversely Related to Age. Diabetes 30: 718, 1981.

BOOK CHAPTERS:

Godwin UB, Flores M, Wilson MR, Quiniou S, Miller NW, Clem LW, and McConnell TJ. Two MHC class II A loci in the channel catfish. In: Major Histocompatibility Complex Evolution, Structure, and Function (ed. Masanori Kasahara) pp. 260-272. Springer-Verlag 2000.

MorizotDC and McConnell TJ. Immunology of fishes. Red blood cell antigens. In Handbook of Vertebrate Immunology (eds. Pastoret, P.-P., Griebel, P., Bazin, H., and Govaerts, A.) pp. 25-26. Academic Press, London. 1998.

Wakeland, EK, Tarnuzzer, RW, Lu C, Potts W, McIndoe RA, Talbot WS, and McConnell TJ. The Evolution of MHC class II genes within the genus Mus. In: H-2 Antigens: Genes, Molecules, Function. C. David, ed. Plenum Press, New York, P. 139, 1987.

Wakeland EK, McIndoe RA, and McConnell TJ. Genetic Variability of Class II Genes in Wild Mouse Populations. In: The Wild Mouse in Immunology, M. Potter ed. Springer-Verlag, New York, p. 255, 1986.

ABSTRACTS:

Xie C, Li Y-Q, Mannie MD, and McConnell TJ. Detection of Activation States of T Cells with Raman-Tweezers Spectroscopy. Session: CFN  -  Optical Trapping, Manipulation, and Diagnostics, of the Conference on Lasers and Electro-Optics/Quantum Electronics & Laser Science (CLEO/QELS) Conference, Baltimore, MD, 2005.

McConnell TJ, Roney KE, Cuthbertson BJ, Godwin UB, Kazianis S, Coletta L,Rosenthal GG, Ryan MJ, and Schmidt M.  MHC class II DXB transcripts in Xiphophorus fishes and Alternative RNA splicing.  Twelfth International Congress of Immunology, 2004.

Fuller JR, Pitzer JE, Godwin U, Machon BD, Albertino MD, Kearse KP, and McConnell TJ. Calnexin association with the Major histocompatibility complex class II a chain in Ictalurus punctatus. 9^th International Congress of the International Society of Developmental and Comparative Immunology, MHC.4: 98, 2003.

McConnell TJ, Fuller JR, Pitzer JE, Godwin U, Machon BD, Kearse KP, and Albertino MD. Isolation and characterization of calnexin in the channel catfish. 9^th International Congress of the International Society of Developmental and Comparative Immunology, MHC.P7: 173, 2003.

Capraro GA, Godwin UB, Nairn RS, Kazianis S, Morizot DC, Colleta LD, Ryan M, Rosenthal G, and McConnell TJ    Polymorphism of the MHC class II DAB locus in swordtailsXiphophorous multilineatus and Xiphophorus pygmaeus.  63^rd Annual Meeting of the Association of Southeastern Biologists 49(2):105, 2002

Capraro, G.A., Godwin, U.B., Nairn, R.S., Kazianis, S., Morizot, D.C., Colleta, L.D., Ryan, M., Rosenthal, G., and McConnell, T.J.    Polymorphism of the MHC class II DAB locus in swordtails Xiphophorous multilineatus and Xiphophorus pygmaeus.  99^th Annual Meeting of the North Carolina Academy of Science, 2002.

Cuthbertson BJ, Godwin UB, Kazianis S, Nairn RS, Coletta LD, Morizot DC, Rosenthal G, Ryan M, and McConnell, TJ, 2000. Population genetic analysis of MHC class II DXB variability in Xiphophorus fishes. Eighth Congress of the International Society of Developmental and Comparative Immunology 24: S75.

Machon BD, Kearse KP, and McConnell TJ, 2000.The expression of the endoplasmic reticulum protein calnexin in the channel catfish, Ictalurus punctatus. Eighth Congress of the International Society of Developmental and Comparative Immunology 24: S68.

Schmidt M, McConnell TJ, and Hoffman DR, 2000. Expression of recombinant imported fire ant venom allergen Sol I 3. The Journal of Allergy and Clinical Immunology, AAAAI 56th Annual Meeting.

McConnell TJ, Godwin UB, Flores MF, Wilson MR, Quiniou S, Miller NW, and Clem LW, 1999. Two MHC class II A loci in the channel catfish. Sixth International Workshop on the Evolution of the Major Histocompatibility Complex.

McConnell TJ, Godwin UB, Criscitiello MF, and Morizot DC, 1997. Presence of two very different MHC class II B loci in the platyfish. Hereditas 127: 163.

Albertino MD, Godwin UB, Wilson MR, Miller NW, Clem LW, and McConnell TJ, 1997. Cytoplasmic detection of the catfish MHC class II b chain. Developmental and Comparative Immunology 21: 97.

Hogan RJ, Antao A, Wilson MR, Miller NW, Clem LW, Godwin UB, Criscitiello MF, McConnell TJ, Goudie C, Waldbieser G, Wolters W, and Chinchar VG, 1997. Molecular and immunological characterization of gynogenetic catfish. Developmental and Comparative Immunology 21: 103.

Godwin UB, Flores MF, Antao A, Wilson MR, Chinchar VG, Miller NW, Clem LW, and McConnell TJ, 1997. Characterization of the MHC class II A genes of the channel catfish, Ictalurus punctatus. Developmental and Comparative Immunology 21: 108.

Antao A, Wilson MR, Stuge TB, Godwin UB, Criscitiello MF, McConnell TJ, Miller NW, Clem LW, and Chinchar VG, 1997. Expression of major histocompatibility genes in the channel catfish. Developmental and Comparative Immunology 21: 109.

Criscitiello MF, Benedetto R, Antao A, Wilson MR, Chinchar VG, Miller NW, Clem LW, and McConnell TJ, 1997. Glycosylation signal sequence for b2-microglobulin in the channel catfish, Ictalurus punctatus. Developmental and Comparative Immunology 21: 199.

McConnell TJ, Walker RB, Hardee J, Godwin U, and Benedetto RG, 1994. Sequence variability of the Mhc class II A and B genes in Striped bass. VIth International Congress of the International Society for Comparative and Developmental Immunology.

Schmidt M, Walker RB, Hoffman DR, and McConnell TJ, 1993. Cloning and sequencing of the cDNA encoding the imported fireant venom allergen, Sol i II. American Academy of Allergy and Immunology.

Wilde DB, Ezquerra A, Roberts K, McConnell TJ, Coligan JE, and Shevach EM, 1991. Functional and molecular studies of gamma-delta T cells which constitutively secrete cytokines. Abstract #7655, FASEB Abstracts Vol. 5, Number 6.

McConnell TJ, Ezquerra A, Cron RQ, Valas RB, Bluestone JA, and Coligan JE, 1990. T cell receptor delta gene expression and diversity in the mouse spleen. FASEB.

McConnell TJ, Yokoyama W, Kikuchi GE, Einhorn GP, Ezquerra A, Stingl G, Shevach EM, and Coligan JE, 1989. Delta chains of dendritic epidermal T cells are diverse but pair with gamma chains in a restricted manner. 7th International Congress of Immunology.

McConnell TJ, Yokoyama WM, Kikuchi GE, Einhorn GP, Stingl G, Shevach EM, and Coligan JE, 1989. Diversity of gd T cell receptors expressed by murine dendritic epidermal T cells (DETC), FASEB.

Kikuchi GE, Einhorn GP, McConnell TJ, and Coligan JE, 1989. Rearrangement and regulation of expression of the murine T cell receptor delta gene, 4th ICN-UCI Symposium on Protein Nucleic Acid in Interactions in Gene Expression.

Wakeland EK, McConnell TJ, Talbot WS, McIndoe RA, Boehme S, Manning CJ, Dewsbury D, Potts WK, 1988. The origin and selective maintenance of MHC class II gene polymorphisms within the genus Mus. Sixth HLA/H-2 Cloning Workshop, Book of Abstracts.6:109.

Tarnuzzer RW, McIndoe RA, McConnell TJ, and Wakeland EK, 1988. Influence of recombinational hotspots (RHS) on the evolution of the I region haplotypes. The FASEB Journal 2:482.

Coligan JE, Koning F, Yokoyama WM, McConnell TJ, Ezquerra A, Steiner G, Cohen D, Elbe A, Stingl G, and Shevach EM, 1988. Diversity of gd TCR's expressed by dendritic epidermal T cells and cell lines. The FASEB Journal 2:446.

Wakeland EK, Talbot WS, McIndoe RA, and McConnell TJ, 1987. Class II alleles of the murine Major histocompatibility complex diverged prior to speciation in the genus Mus. Federation Proceedings 46:1197.

Tarnuzzer RW, McConnell TJ, and Wakeland EK, 1987. Co-evolutionary relationships of class II loci within the murine I region. Federation Proceedings 46:944.

Wakeland EK, Talbot WS, McIndoe RA, and McConnell TJ, 1986. Evolutionary relationships of I-A alleles: evidence that intron sequence polymorphisms have ancient origins in the genus Mus. Fifth HLA and H-2 Cloning Workshop, Book of Abstracts. 5:29.

McConnell TJ and Wakeland EK, 1985. Patterns of Genetic Diversity of I-A b Alleles in Wild Mice. Advances in Gene Technology: Molecular Biology of the Immune System ICSU Short Reports 2:253.

McConnell TJ and Wakeland EK, 1984. Restriction enzyme site polymorphisms of class II histocompatibility gene sequences in wild mice. Advances in Gene Technology: Human Genetic Disorders ICSU Short Reports 1:208.

McConnell TJ, McIndoe RA, and Wakeland EK, 1984. Patterns of genetic diversity among class II histocompatibility genes in wild mice. Federation Proceedings 44:557.

Wakeland EK, McConnell TJ, Darby B, and Coligan JE, 1984. Genetic diversity of class II histocompatibility genes in wild mice. Journal of Cellular Biochemistry, 13th Annual UCLA Symposia.

PROFESSIONAL SOCIETIES:

International Society of Developmental and Comparative Immunology