Title: Associate Professor
Area of Study: Molecular Genetics, Molecular Toxicology, Biotechnology
Phone: Office - 252-328-2021, Lab - 252-737-4767
E-mail: email@example.comOffice: 562 Science and Technology Building
Lab: 535 Science and Technology Building
Address: Department of Biology
East Carolina University
Greenville, NC 27858
Ph.D., Environmental Toxicology, Texas Tech University, 2006
B.A., Plant Genetics and Breeding, Beijing Agricultural University, 1991
BIOL 3820. Plant Biotechnology (For Fall Semester).
The research in Dr. Zhang's lab focuses on three related fields: molecular genetics, toxicology, and biotechnology.
NIH NSF USDA DoE DoD
NCBC Cotton Inc. Dupont
genomics, genetics and biotechnology-related publications
1. Li C, Unver T, & Zhang BH (2017) A
high-efficiency CRISPR/Cas9 system for targeted mutagenesis in cotton (Gossypium hirsutum L.). Scientific Reports, 7:43902 | DOI:
2. Alagoz Y, Gurkok T, Zhang BH, and Unver T (2016) Manipulating the biosynthesis of
bioactive compound alkaloids for next-generation metabolic engineering in opium
poppy using CRISPR-Cas 9 genome editing technology. Scientific Reports, 6: 30910. doi: 10.1038/srep30910.
3. Candar-Çakir B*, Arican E, and Zhang BH (2016) Small RNA and degradome
deep Sequencing reveals drought- and Tissue-specific microRNAs and their
important roles in drought-sensitive and -tolerant tomato genotypes. Plant Biotechnology Journal,
14(8):1727-46. doi: 10.1111/pbi.12533.
4. He QL, Jones DC, Li W, Xie FL*, Ma J*, Sun RR*,
Wang QL, Zhu SJ, and Zhang BH (2016)
Genome-wide identification of R2R3-MYB genes and expression analyses during
abiotic stress in Gossypium raimondii.
Scientific Reports, 6:22980. doi:
5. Zhang ZY, Chao MN, Wang SF, Bu JJ, Tang JX, Li
F, Wang QL, and Zhang BH (2016)
Proteome quantification of cotton xylem sap suggests the mechanisms of
potassium-deficiency-induced changes in plant resistance to environmental
stresses. Scientific Reports, 6:
21060. doi: 10.1038/srep21060
6. Cakir O, Candar-Cakir B*, & Zhang BH (2016) Small RNA and degradome
sequencing reveals important microRNA function in Astragalus chrysochlorus response to selenium stimuli. Plant Biotechnology Journal,
14(2):543-56. doi: 10.1111/pbi.12397.
7. Ma J*, Liu F, Wang QL, Wang KB, Jones D, & Zhang BH (2016) Comprehensive analysis
of TCP transcription factors and their expression during cotton (Gossypium arboreum) fiber early
development. Scientific Reports,
6:21535. doi: 10.1038/srep21535.
8. Gao S, Yang L, Zeng HQ, Yang ZM, Li H, Sun D, Zhou
ZS, Xie FL*, Zhang BH (2016) A cotton miRNA is involved in regulation of
plant response to salt stress. Scientific
Reports, 6:19736. doi: 10.1038/srep19736.
9. Xie FL*, Wang QL, and Zhang BH (2015) Global microRNA modification in cotton (Gossypium hirsutum L.). Plant Biotechnology Journal, 13(4): 492-500. doi: 10.1111/pbi.12271.
10. Zhang BH (2015) MicroRNA: a new
target for improving plant tolerance to abiotic stress. Journal
of Experimental Botany, 66
(7): 1749-1761 doi: 10.1093/jxb/ erv013
JL, Zhang BH and Stewart CN (2015)
microRNAs for improved biomass and biofuels from plant feedstocks. Plant Biotechnology Journal,
13(3):337-54. doi: 10.1111/pbi.12319.
12. Xie FL*, and Zhang BH (2015) MicroRNA evolution and expression
analysis in polyploidized cotton genome. Plant Biotechnology Journal, 13(3): 421-434. doi:
13. Xie FL*, Jones DC, Wang QL, Sun RR, and Zhang BH (2015) Small RNA sequencing identifies miRNA
roles in ovule and fiber development. Plant
Biotechnology Journal, 13(3): 355-369. doi: 10.1111/pbi.12296.
FL*, Wang QL, Sun RR*, and Zhang BH
(2015) Deep sequencing reveals important roles of microRNAs in response to
drought and salinity stress in cotton. Journal
of Experimental Botany,
66(3): 789-804. doi: 10.1093/jxb/eru437
15. Xie FL*,
Stewart N, Taki FA*, He QL, Liu
HW & Zhang BH (2014) High
throughput deep sequencing shows that microRNAs play important roles in
switchgrass responses to drought and salinity stress. Plant Biotechnology Journal,
and computational biology-related publications
TP, Palmer NA, Xie FL*, Tobias CM,
Donze-Reiner TJ, Bombarely A, Childs KL, Shu SQ, Jenkins JW, Schmutz J, Zhang BH, Sarath G and Zhao BY (2016) Identification, characterization, and gene
expression analysis of nucleotide binding site (NB)-type resistance gene
homologues in switchgrass. BMC Genomics,
17:892. DOI: 10.1186/s12864-016-3201-5
17. Ma J*, Wang QL, Sun RR, Xie FL*, Jones DC, and Zhang BH (2014) Genome-wide identification
and expression analysis of TCP transcription factors in Gossypium raimondii. Scientific Reports 4: 6645. doi:10.1038/srep06645
18. Xie FL*, Xiao P, Chen DL*, Xu L* & Zhang,
miRDeepFinder: a miRNA analysis tool for deep sequencing of plant small RNAs. Plant Molecular Biology, 80 (1): 75-84.
19. Xie FL*,
Sun GL, Stiller JW & Zhang, Baohong (2011) Genome-wide functional
analysis of the cotton transcriptome by creating an integrated EST database. PLOS One, 6(11):e26980 doi: 10.1371/journal.pone.0026980
20. Xie FL*
& Zhang, Baohong (2010). Target-align: a tool for plant
microRNA target identification. Bioinformatics, 26(23):
and health health-related publications
21. O’Donnell B*,
Huo L, Polli JR, Qiu L, Collier D, Zhang
BH, & Pan XP. (2016) ZnO nanoparticles enhanced germ cell apoptosis in Caenorhabditis elegans, in comparison
with ZnCl2. Toxicological Sciences
FA*, Pan XP & Zhang BH (2015)
Revisiting Chaos theorem to understand the nature of
miRNAs in response to drugs of abuse. Journal
of Cellular Physiology, 230(12):2857-68. doi: 10.1002/jcp.25037.
JR#, Dobbins DL*, Kobet RA#, Farwell MA, Zhang
BH, Lee MH, and Pan X (2015) Drug-Dependent Behaviors and Nicotinic
Acetylcholine Receptor Expressions in Caenorhabditis
elegans Following Chronic Nicotine Exposure. NeuroToxicology, 47: 27-36.
24. Taki FA *, Pan XP, Lee MH and Zhang BH (2014) Nicotine exposure and
transgenerational impact: a prospective study on small regulatory microRNAs. Scientific Reports 4: 7513;
25. Kobet RA#, Pan XP, Zhang BH, Pak SC, Asch AS and Lee MH (2014) Caenorhabditis elegans: a model system for anti-cancer drug
discovery and therapeutic target identification. Biomolecules & Therapeutics, 22(5): 371-383.
FA *, Abdel-Rahman AA and Zhang BH (2014)
A comprehensive approach to identify reliable reference gene candidates to
investigate the link between alcoholism and endocrinology in Sprague-Dawley
rats. PLOS One 9(5):e94311.
FA *, Pan XP & Zhang BH (2014) Chronic nicotine exposure
systemically alters microRNA expression profiles during post-embryonic stages
in Caenorhabditis elegans. Journal of Cellular Physiology, 229(1): 79-89. doi: 10.1002/jcp.24419.
FA *, Pan XP & Zhang, Baohong
(2013) Nicotine exposure caused significant transgenerational heritable
behavioral changes in Caenorhabditis
elegans. EXCLI Journal,
MA *, Zhang Y *, Polli JR #, Wu H, Zhang, Baohong, Xiao P, Farwell MA, and Pan X (2013) Impacts of
chronic low-level nicotine exposure on Caenorhabditis
elegans reproduction: identification of novel gene targets. Reproductive Toxicology, 40: 69-75. doi:
YQ*, Chen DL*, Ennis AC#, Polli JR#, Xiao P, Zhang, Baohong, Stellwag EJ, Overton A, & Pan XP (2013)
Chemical dispersant potentiates crude oil impacts on growth, reproduction, and
gene expression in Caenorhabditis elegans.
Achieves of Toxicology, 87(2):371-382. DOI
MY*, Pan XP, Fix LN*, Farwell MA & Zhang, Baohong (2011) 5-fluorouracil
drug alters the microRNA expression profiles in MCF-7 breast cancer cells. Journal
of Cellular Physiology, 226(7):
Ilya N. Boykov
Daniel H. Parker
Kaeden M. Jordison
A Adams (M.S., 2016), now technician at RTP, NC
Taki (M.S., 2013; Ph.D., 2016), now Postdoctoral scholar at Cornell University
Ma (M.S., 2015), now Ph.D. student at NC State University
Xie (Ph.D., 2014), now research scientist of bioinformatics at RTP, NC
Winfrey (M.S., 2013) now MD students at
ECU Brody School of Medicine
E. Burklew (M.S., 2012), now scientist
at Excet Inc.
Nicole Fix (M.S., 2010), now MD
students at ECU Brody School of Medicine
Price Frazier (M.S., 2010), now Postdoctoral
Scholar at University of Tennessee
Maitri Yogen Shah (M.S., 2010),
now Ph.D. student at MD Anderson Cancer Center
Dr. Zhang’s lab is now accepting graduate students (M.S. and
Ph.D.) who have an interest in molecular genetics, molecular toxicology, and/or
biotechnology. The Department of Biology has a Master of Science degree program
and an Interdisciplinary Ph.D. degree program (IDPBS). Currently, graduate
students in Dr. Zhang’s lab have the freedom to choose their study organism(s)
and system. If you are interested in working with me, you should contact Dr.
Zhang directly to discuss the details and possibilities. You may stop by Dr.
Zhang’s office at Science and Technology
Building 562 (office) or 535 (Lab) or
email Dr. Zhang at firstname.lastname@example.org. Dr.
Zhang’s lab is keen on accepting students who are enthusiastic, hard working,
and interested in facing challenges and solving questions related to molecular
genetics, molecular toxicology, and/or biotechnology. Many graduate students in
Dr. Zhang’s lab have won national and international awards and had at least two
publications when they graduated.
Undergraduate students, particularly freshman and
junior, are also welcome and encouraged
to join Dr. Zhang’s lab to gain research experience. If interested, you may
also directly stop by Dr. Zhang’s office or email him to discuss possible
research opportunities. Many undergraduate students have generated publications
as co-authors in Dr. Zhang’s lab.