Area of Study: Comparative, developmental, and Molecular Endocrinology
Office: N413 Howell Science
Address: Department of Biology
East Carolina University
Greenville, NC 27858
Postdoctoral fellow: in Comparative & Molecular Endocrinology & Protein Biochemistry, Marine Science Institute, University of Texas at Austin, Port Aransas, Texas 1993-2001
Postdoctoral fellow: in Biotechnology & Protein Biochemistry, Central Research Institute, Maruha Co, Tsukuba, Japan, 1991-1992
Ph.D.: in Comparative Endocrinology at University of Tokyo, Tokyo, Japan 1991.
M.Sc.: in Reproductive & Comparative Physiology, University of Tokyo, Tokyo, Japan 1988.
B.Sc.: in Marine Biology, Xiamen University, Xiamen, China 1984.
BIOL 3320 The Principles of Animal Physiology (undergraduate course).
BIOL 5630 Comparative Animal Physiology (graduate course for MS candidates and senior undergraduates)
BIOL 6082 Fundamentals of Vertebrate Endocrinology (graduate course for PhD/MS candidates)
BIOL 7080 Molecular Endocrinology (graduate course for PhD/MS candidates)
BIOL 7630 Fish Physiology (graduate course for PhD/MS candidates)
BIOL 7890 Current Literatures in Molecular Biology (graduate course)
Frye, C.A., Walf, A.A., Kohtz, A.S., Zhu, Y. (2013) Membrane progestin receptors in the midbrain ventral tegmental are required for progesterone-facilitated lordosis of rats. Horm Behav. 2013 Jun 12. doi:pii: S0018-506X(13)00124-4. 10.1016/j.yhbeh.2013.05.012.
Cánepa, M.M., Zhu, Y., Fossati, M., Stiller, J.W., Vissio, P.G. (2012) Cloning, phylogenetic analysis and expression of somatolactin and its receptor in Cichlasomadimerus: Their role in long-term background color acclimation. Gen Comp Endocrinol. 176, 52-61.
Hanna RN*, Zhu Y (2011). Controls of meiotic signaling by membrane or nuclear progestin receptor in zebrafish follicle-enclosed oocytes. Molecular and Cellular Endocrinology. 337:80-88.
Diotel N,Servili A,Gueguen MM,Mironov, S,Pellegrini, E,Vaillant C,Zhu Y,Kah, O,Anglade I. (2011) Nuclear progesterone receptors are up-regulated by estrogens n neurons and radial glial progenitors in the brain of zebrafish. PLoS One.6(11): e28375.
Hanna RN*, Daly SC*, Pang Y, Anglade I, Kah O, Thomas P, Zhu Y (2010) Characterization and expression of the nuclear progestin receptor in zebrafish gonads and brain. Biol Reprod. 82:112-22.
Carnevali O, Tosti L, Speciale C, Peng C, Zhu Y, Maradonna F (2010) DEHP impairs zebrafish reproduction by affecting critical factors in oogenesis. PLoS One. 5:e10201.
Nguyen, N*, Zhu Y (2009) Prolactin functions as a survival factor during zebrafish embryogenesis. Comp Biochem Physiol A Mol Integr Physiol.153; 88-93
Hanna R*, Zhu Y (2009) Expression of membrane progestin receptors in zebrafish (Danio rerio) oocytes, testis and pituitary. General and Comparative Endocrinology161: 153-157
Nguyen N*, Stellwag EJ, Zhu Y (2008) Prolactin modulating organogenesis in the vertebrate-recent discoveries in zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 148:370-380.
ZhuY, HannaRN*, Schaaf MJ, Spaink HP, ThomasP (2008) Candidates for membrane progestin receptors in vertebrate gametes—past approaches and future challenges. Comp Biochem Physiol C Toxicol Pharmacol. 148:381-389. (It was a top cited article between 2008-2010 for the journal)
Summers K, Zhu Y (2008) Positive selection on a prolactin paralog following gene duplication in cichlids: adaptive evolution in the context of parental care? Copeia, 4: 872-976.
Xie C*, Nguyen N*, Zhu Y, Li Q (2007) Detection of the recombinant proteins in single transgenic microbial cells using laser tweezers and ramen spectroscopy. Analytical Chemistry 79:9269-9275.
Zhu Y, Song D*, Tran N*, Nguyen N* (2007)The effects of the members of growth hormone family knockdown in zebrafish development. General and Comparative Endocrinology 150: 395-404.
Thomas P, Pang Y, Dong J, Groenen P, Kelder J, de Vlieg J, Zhu Y, Tubbs C* (2007) Steroid and G Protein Binding Characteristics of the Seatrout and Human Progestin Membrane Receptor Alpha Subtypes and Their Evolutionary Origins. Endocrinology 148: 705-718.
Hanna RN*, Pang Y, ThomasP, Zhu Y (2006) Cell Surface Expression, Progestin Binding and Rapid Nongenomic Signaling of Zebrafish Membrane Progestin Receptors α and β in Transfected Cells. Journal of Endocrinology 190: 247 - 260.
Nguyen N*, Sugimoto M, Zhu Y (2006) Production and purification of recombinant somatolactin β and its effects on melanosome aggregation in zebrafish. General and Comparative Endocrinology 145: 182-187.
Zhu Y, Stiller JW, Shaner MP*, Baldini A*, Scemama JL, Capehart AA (2004) Cloning of somatolactin a and cDNAs in zebrafish and phylogenetic analysis of two distinct somatolactin subtypes in fish. Journal of Endocrinology 182: 509-518.
Thomas P, Pang Y, Zhu Y, Detweiler C*, Doughty K* (2004) Multiple rapid progestin actions and progestin membrane receptor subtypes in fish. Steroids 69:567-573.
Zhu Y, Rice CD, Pang Y, Pace M, Thomas P (2003) Cloning, expression and characterization of a novel membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. Proc. Natl. Acad. Sci. USA 100: 2231-2236. (The article has been cited over 300 times)
Zhu Y, Bond JE, Thomas P (2003) Identification, classification and partial characterization of genes in humans and other vertebrates homologous to a novel fish membrane progestin receptor. Proc. Natl. Acad. Sci. USA 100:2237-2242. (The article has been cited over 300 times)
Undergraduate Research Assistant
Undergraduate Research Assistant