Allison Stokes Danell
Associate Professor, Analytical Chemistry
Research Overview
Research in the Danell lab is focused on fundamental studies and applications of mass spectrometry technology. Mass spectrometry analysis occurs in a unique environment because there is no water or other solvent surrounding the molecules inside a mass spectrometer. We are particularly interested in learning more about gas phase structure to further the application of mass spectrometry to problems of biological significance. Project areas include:
- Using a Dual Polarity Dual nanoESI Quadrupole Ion Trap to Characterize Changes in Biomolecule Conformations from Solution to Gas Phase
- ESI-induced Shifts in Metal-Peptide Equilibria
- Collaborative research with colleagues in Pharmacology & Toxicology, Chemistry, and other areas
Selected Publications
Satterwhite, J. E.**; Pugh, A. M.*; Danell, A. S.; Hvastkovs, E. G. "Electrochemical Detection of anti-Benzo[a]pyrene Diol Epoxide DNA damage on TP53 Codon 273 Oligomers", Anal. Chem. 2011, 83, 3327-3335.
Myer, M. J.**; Danell, R. M.; Danell, A. S. "A Simple Dual Polarity Dual nanoElectrospray Ionization Source for Ion/Ion Reactions", Rev. Sci. Instrum. 2010, 81, 066103.
Mattapalli, H.**; Monteith, W. B.*; Burns, C. S.; Danell, A. S. "Zinc Deposition During ESI-MS Analysis of Peptide-Zinc Complexes", J. Am. Soc. Mass Spectrom. 2009, 20, 2199-2205.
Romack, T. J.; Danell, A. S.; Cottone, T. M.*; Dutta, S. K. "Electrospray Ionization Time of Flight Mass Spectrometry Characterization of Perfluoroalkyl Acrylic Oligomers", Rapid Commun. Mass Spectrom. 2008, 22, 930-934.
Unnithan, A. G.*; Myer, M. J.**; Veale, C. J.*; Danell, A. S. "MS/MS of Protonated Polyproline Peptides: The Influence of N-terminal Protonation on Dissociation", J. Am. Soc. Mass Spectrom. 2007, 18, 2198-2203.
Wilson, C. L.**; Monteith, W. B.*; Danell, A. S.; Burns, C. S. "Purification and Characterization of the Central Segment of Prothymosin-a: Methodology for Handling Highly Acidic Peptides", J. Peptide Sci. 2006, 12, 721-725.
Danell, A. S.; Parks, J. H. “Fraying and Electron Autodetachment Dynamics of Trapped Gas Phase Oligonucleotides”, J. Am. Soc. Mass Spectrom. 2003, 14, 1330-1339.
Danell, A. S.; Parks, J. H. "FRET Measurements of Trapped Oligonucleotide Duplexes", Int. J. Mass Spectrom. 2003, 229, 35-45.
Danell, R. M.; Danell, A. S.; Vachet, R. W.; Glish, G. L. “The Use of Static Pressures of Heavy Gases Within a Quadrupole Ion Trap Mass Spectrometer”, J. Am. Soc. Mass Spectrom. 2003, 14, 1099-1109.
* ECU undergraduate student
** ECU graduate student
