Allison Stokes Danell

Associate Professor, Department of Chemistry
Adjunct Associate Professor, Department of Pharmacology and Toxicology

Office: Science and Technology Building 591
Phone: (252) 328-9766
Email: danella@ecu.edu

Postdoctoral Fellow, Rowland Institute at Harvard (2002-2004)
Ph.D., Chemistry, University of North Carolina at Chapel Hill (2001)
B.S., Chemistry, Truman State University (1996)

Research Overview

Analytical chemistry research in the Danell Lab is focused on fundamental studies and applications of mass spectrometry technology. Mass spectrometry analysis occurs in a unique environment because there is no water or other solvent surrounding the molecules inside a mass spectrometer. We are particularly interested in learning more about gas phase structure to further the application of mass spectrometry to problems of biological significance. Project areas include:

  • ESI-induced Shifts in Metal-Peptide Equilibria
  • Collaborative research with colleagues in Pharmacology & Toxicology, Chemistry, Pediatrics, and other areas

Selected Publications

Garapati, S.**, Monteith, W.*, Wilson, C.**, Kostenko, A.**, Kenney, J. M., Danell, A. S., Burns, C. S.  “Zn2+-Binding in the Glutamate-Rich Region of the Intrinsically Disordered Protein Prothymosin-alpha.”  J. Biol. Inorg. Chem. 2018, accepted for publication.

Robb, A. J.*; Vinogradov, S. M.**; Danell, A. S.; Anderson, E.; Blackledge, M. S.; Melander, C.; Hvastkovs, E. G.  "Electrochemical Detection of Small Molecule Induced Pseudomonas aeruginosa Biofilm Dispersion." Electrochim. Acta, 2018, 268, 276-282.

Wentz, W. P.**, Danell, A. S.  "Improving the Reliability of Mass Spectrometry Measurements of Peptide-Zinc(II) Binding Constants."  Int. J. Mass Spectrom. 2017, 421, 124-128.

Soliman, E., Henderson, K. L.**, Danell, A. S., and Van Dross, R. "Arachidonoyl-ethanolamide Activates Endoplasmic Reticulum Stress-Apoptosis in Tumorigenic Keratinocytes: Role of Cyclooxygenase-2 and Novel J-series Prostamides." Mol. Carcinog. 2016, 55, 117-130. DOI:10.1002/mc.22257

Ellison, M. L., Farrow III, J. M., Parrish, W. A.**, Danell, A. S., and Pesci, E. C. "The Transcriptional Regulator Np20 is the Zinc Uptake Regulator in Pseudomonas aeruginosa." PLoS One. 2013, 8, e75389.

Satterwhite, J. E.**; Trumbo, C. M.**; Danell, A. S.; Hvastkovs, E. G. "Electrochemical Study on the Effects of Epigenetic Cytosine Methylation on Anti-Benzo[a]pyrene Diol Epoxide Damage at TP53 Oligomers." Anal. Chem. 2013, 83, 1183-1191.

Satterwhite, J. E.**; Pugh, A. M.*; Danell, A. S.; Hvastkovs, E. G. "Electrochemical Detection of anti-Benzo[a]pyrene Diol Epoxide DNA damage on TP53 Codon 273 Oligomers", Anal. Chem. 2011, 83, 3327-3335.

Myer, M. J.**; Danell, R. M.; Danell, A. S. "A Simple Dual Polarity Dual nanoElectrospray Ionization Source for Ion/Ion Reactions", Rev. Sci. Instrum. 2010, 81, 066103.

Mattapalli, H.**; Monteith, W. B.*; Burns, C. S.; Danell, A. S. "Zinc Deposition During ESI-MS Analysis of Peptide-Zinc Complexes", J. Am. Soc. Mass Spectrom. 2009, 20, 2199-2205.

Romack, T. J.; Danell, A. S.; Cottone, T. M.*; Dutta, S. K. "Electrospray Ionization Time of Flight Mass Spectrometry Characterization of Perfluoroalkyl Acrylic Oligomers", Rapid Commun. Mass Spectrom. 2008, 22, 930-934.

Unnithan, A. G.*; Myer, M. J.**; Veale, C. J.*; Danell, A. S. "MS/MS of Protonated Polyproline Peptides: The Influence of N-terminal Protonation on Dissociation", J. Am. Soc. Mass Spectrom. 2007, 18, 2198-2203.

Wilson, C. L.**; Monteith, W. B.*; Danell, A. S.; Burns, C. S. "Purification and Characterization of the Central Segment of Prothymosin-a: Methodology for Handling Highly Acidic Peptides", J. Peptide Sci. 2006, 12, 721-725.

* ECU undergraduate student ** ECU graduate student


J-series prostaglandin-ethanolamides as novel therapeutics.  US Patent 9,328,060, May 3, 2016.