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Department of Chemistry
Allison Stokes Danell




 
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Contact Information:
Office:  SZ 591
Phone:  (252)328-9766
Email: 
danella@ecu.edu

Courses Taught:
Chem. 2250
Quantitative Analysis
Chem. 2251
Quantitative Analysis Lab
Chem. 7524
Advanced Analytical Chemistry

More about...
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Allison Stokes Danell
Associate Professor, Analytical Chemistry
Interim Chair, Department of Chemistry

Postdoctoral Fellow, Rowland Institute at Harvard (2002-2004)
Ph.D., Chemistry, University of North Carolina at Chapel Hill (2001)
B.S., Chemistry, Truman State University (1996)

Research Overview

Research in the Danell lab is focused on fundamental studies and applications of mass spectrometry technology.  Mass spectrometry analysis occurs in a unique environment because there is no water or other solvent surrounding the molecules inside a mass spectrometer.  We are particularly interested in learning more about gas phase structure to further the application of mass spectrometry to problems of biological significance. Project areas include:

  • Using a Dual Polarity Dual nanoESI Quadrupole Ion Trap to Characterize Changes in Biomolecule Conformations from Solution to Gas Phase
  • ESI-induced Shifts in Metal-Peptide Equilibria
  • Collaborative research with colleagues in Pharmacology & Toxicology, Chemistry, and other areas


Selected Publications


Ellison, M.L., Farrow III, J.M., Parrish, W.A.**, Danell, A.S., and Pesci, E.C. "The Transcriptional Regulator Np20 is the Zinc Uptake Regulator in Pseudomonas aeruginosa." PLoS One. 2013, 8, e75389.


Satterwhite, J. E.**; Trumbo, C. M.**; Danell, A. S.; Hvastkovs, E. G. "Electrochemical Study on the Effects of Epigenetic Cytosine Methylation on Anti-Benzo[a]pyrene Diol Epoxide Damage at TP53 Oligomers."  Anal. Chem. 2013, 83, 1183-1191.


Satterwhite, J. E.**; Pugh, A. M.*; Danell, A. S.; Hvastkovs, E. G. "Electrochemical Detection of anti-Benzo[a]pyrene Diol Epoxide DNA damage on TP53 Codon 273 Oligomers", Anal. Chem. 2011, 83, 3327-3335.

 

Myer, M. J.**; Danell, R. M.; Danell, A. S.  "A Simple Dual Polarity Dual nanoElectrospray Ionization Source for Ion/Ion Reactions", Rev. Sci. Instrum. 201081, 066103.

 

Mattapalli, H.**; Monteith, W. B.*; Burns, C. S.; Danell, A. S.  "Zinc Deposition During ESI-MS Analysis of Peptide-Zinc Complexes", J. Am. Soc. Mass Spectrom. 2009, 20, 2199-2205.

Romack, T. J.; Danell, A. S.; Cottone, T. M.*; Dutta, S. K.  "Electrospray Ionization Time of Flight Mass Spectrometry Characterization of Perfluoroalkyl Acrylic Oligomers", Rapid Commun. Mass Spectrom. 2008, 22, 930-934.

 

Unnithan, A. G.*; Myer, M. J.**; Veale, C. J.*; Danell, A. S.  "MS/MS of Protonated Polyproline Peptides: The Influence of N-terminal Protonation on Dissociation", J. Am. Soc. Mass Spectrom. 2007, 18, 2198-2203.

 

Wilson, C. L.**; Monteith, W. B.*; Danell, A. S.; Burns, C. S.  "Purification and Characterization of the Central Segment of Prothymosin-a:  Methodology for Handling Highly Acidic Peptides", J. Peptide Sci. 2006, 12, 721-725.

Danell, A. S.; Parks, J. H.  “Fraying and Electron Autodetachment Dynamics of Trapped Gas Phase Oligonucleotides”, J. Am. Soc. Mass Spectrom. 2003, 14, 1330-1339.

Danell, A. S.; Parks, J. H.  "FRET Measurements of Trapped Oligonucleotide Duplexes", Int. J. Mass Spectrom. 2003, 229, 35-45.

Danell, R. M.; Danell, A. S.; Vachet, R. W.; Glish, G. L. “The Use of Static Pressures of Heavy Gases Within a Quadrupole Ion Trap Mass Spectrometer”, J. Am. Soc. Mass Spectrom. 2003, 14, 1099-1109.

* ECU undergraduate student
** ECU graduate student