Art A. Rodriguez

Title: Professor, Physical and Biophysical Chemistry
Office: SZ 571
Phone: (252) 328-9804

Ph.D., University of North Texas, 1987
B.S., Sul Ross State University, 1982

Research Overview

We are employing fullerenes as model systems to probe molecular dynamics and complexation properties with macromolecules of biological significance. These studies are also being used to develop a universal model for describing molecular dynamics in liquids.

Our group is currently utilizing quantum dots to develop biosensors for diagnostic purposes. The diagnostic technique currently being used to test for prostate cancer (CaP) is dependent on detecting prostate-specific antigen (PSA) levels in the serum. This diagnostic protocol is however limited since frequently it can not differentiate between CaP and benign prostate hyperplasia (BPH). The recent discovered correlation between the over-expressed protein delta-catenin and the occurrence of prostate cancer (CaP) provides a unique opportunity for developing a specific diagnostic essay based on this correlation. The scientific question we are addressing in the initial phase of this project is the feasibility of developing a QD-biosensor that is robust, sensitive, and highly selective toward detecting the delta-catenin protein.

Selected Publications

Garapati, S., Burns, C. S., & Rodriguez, A. A. (2014). Field- and Temperature-Dependent 13C NMR Studies of the EDTA-Zn2+ Complex: Insight into Structure and Dynamics via Relaxation Measurements" Journal of Physical Chemistry B, 118, 12960-12964.

Ramisetty, M., Rodriguez, A., Aneja, A., & Wang, Y. (2013). Solvent Induced Fissure Life-Stage Analysis Under Static Stress in Poly(ethylene terephthalate) Fibers. International Polymer Processing, 28, 376-385.

Rodriguez, A. A. & Obondi, C. (2010). NMR Studies into the Potential Interactions of Fullerene C60 with Tetraphenylporphyrin and Some of its Derivatives. Advances in Physical Chemistry, 2010 (102167), 9.

Hughes, R. M., Mutzenhardt, P., & Rodriguez, A. A. (2009). Comparison of the molecular dynamics of C70 in the solid and liquid phases. Advances in Physical Chemistry.

Hughes, R. M., Mutzenhardt, P., & Bartolotti, L. (2008). Experimental and theoretical analysis of the reorientational dynamics of fullerene C70 in various aromatic solvents. Journal of Physical Chemistry Part A, 112 (18), 4186.

Hughes, R., Mutzenhardt, P., Bartolotti, L., & Rodriguez, A. A. (2005). Analysis of the Spin-Lattice Relation Rate and Reorientational Dynamics of Fullerene C70 in Chlorobenzene-d5. Journal of Molecular Liquids, 116, 139.

Nichols, K. & Rodriguez, A. A. (2005). Comparison of and investigation into the size effects on the rotational dynamics of two spherical molecules: CCl4 and C60. Journal of Physical Chemistry Part A, The, 109 (13), 3009.

Martin, N. H. & Rodriguez, A. A. (2005). Field Dependent Relaxation and Molecular Dynamics of C60 in Chlorobenzene-d5: Addendum. Journal of Physical Chemistry Part A, The, 109 (03), 534.

Martin, N., Issa, M., & Rodriguez, A. A. (2000). Field Dependent Relaxation and Molecular Dynamics of C60 in Chlorobenzene-d5. Journal of Physical Chemistry, 104 (48), 11278.