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Lim150

Kwang Hun Lim

Title: Associate Professor, Physical Chemistry
Office:
SZ 574
Phone: (252) 328-9805
Email:limk@ecu.edu

Postdoctoral Fellow, UC-Berkeley, 2000-2003
PhD Chemistry, SUNY-Stony Brook, 1999
MS Chemistry, POSTECH, Korea, 1995
BS Chemistry, POSTECH, Korea, 1992

Research Overview

My research interest lies in the application of NMR spectroscopy to biophysical studies of proteins, such as protein folding/misfolding, and to environmental sciences. Current researches are focused on amyloidogenic proteins that are related to many types of neurodegenerative diseases. In addition, solid-state NMR spectroscopy has been used to characterize (activated) biochar that can potentially be used for water purification.

Selected Publications

K. H. Lim*, A. K. R. Dasari, I. Hung, Z. Gan, J. W. Kelly, P. E. Wright, D. E. Wemmer*, "Solid-State NMR Studies Reveal Native-like β-Sheet Structures in Transthyretin Amyloid", Biochemistry, 2016, 55, 5272–5278.

K. H. Lim*, A. K. R. Dasari, I. Hung, Z. Gan, J. W. Kelly, D. E. Wemmer*,  "Structural Changes Associated with Transthyretin Misfolding and Amyloid Formation Revealed by Solution and Solid-State NMR", Biochemistry. 2016, 55, 1941-1944.

K. H. Lim*, J. W. Kelly, H. J. Dyson, and P. E. Wright*, "Localized Structural Fluctuations Promote Amyloidogenic Conformations in Transthyretin", Journal of Molecular Biology. 2013, 425, 977-988.

K. H. Lim*, "Molecular Basis of Amyloid Polymorphism: Multiple Misfolding Pathways", J. Phys. Chem. Biophys., 2013, 3:e112 doi:10.4172/2161-0398.1000e112.

J. Park, K. H. Lim, O. Rojas, and S. Park*, "Transformation of lignocellulosic biomass during torrefaction", Journal of Analytical and Applied Pyrolysis. 2013, 100, 199-206.

J. Park, O. Rojas, K. H. Lim*, and S. Park*, "Activated carbon from biochar: Influence of physicochemical properties of biochar on the characteristics of its activated counterparts", Bioresource Technology. 2013, 149, 383-389.

C. Jung, J. Park, K. H. Lim, S. Park, J. Heo, N. Her, J. Oh, S. Yun, and Y. Yoon*, "Adsorption of selected endocrine disrupting compounds and pharmaceuticals on activated biochars", Journal of Hazardous Materials. 2013, 263, 702-710.

K. H. Lim*, Y. T. Le, H. H. Collver, C. Putnam-Evans and J. M. Kenney, "Characterization of Amyloidogenic Intermediate States through a Combined Use of CD and NMR Spectroscopy", Biophys. Chem., 2010, 151, 155-159

K. H. Lim*, P. Nagchowdhuri, T. Rathinavelan, and W. Im, "NMR Characterization of Hydrophobic Collapses in Amyloidogenic Unfolded States and Their Implications for Amyloid Formation", Biochem. Biophys. Res. Commun., 2010, 396, 800-805.

K. H. Lim*, Y. K. Kim, and Y. T. Chang, "Investigations of the Molecular Mechanism of Metal-Induced Ab (1-40) Amyloidogenesis", Biochemistry, 2007, 46, 13523-13532.