The Department of Chemistry and the Pharmaceutical Development and Manufacturing Center of Excellence
operate several mass spectrometers on a fee for service basis:
- LC/qTOF-MS: Appropriate samples are less volatile, higher molecular weight analytes amenable to Electrospray Ionization (ESI), which usually multiply protonates or deprotonates the analyte. Some sample preparation (clean-up) is usually required, such as solid phase extraction, prior to using this instrument.
- GC/MS: Samples should be low molecular weight (< 500 Da) and volatile. Electron Ionization (EI) and Chemical Ionization (CI) are the ionization techniques available on this instrument. The mass spectra provide significant structural information because of the extensive fragmentation that occurs.
- MALDI/TOF-MS: Samples for this instrument can typically be more complex than with the LC/qTOF-MS because MALDI is more tolerant of salts and buffers often found in biological samples. MALDI imaging is also available, so any samples requiring spatial resolution are suitable for this instrument (e.g. tissue samples).
- ICP/MS: If you need to determine the concentration of practically any element on the periodic table (or various isotopes) at levels as low as 10 parts-per-trillion (or less), then this is the best instrument for your application.
Fee schedules are still being prepared, but contact Dr. Kew or Dr. Pender to discuss your specific needs and a customized quote can be developed. For internal users, payment can be easily processed by Interdepartmental Transfer (IDT). And given the educational mission of both the department and the center, student involvement is encouraged.
Jack E. Pender, PhD
Principal Research Scholar
Director, Pharmaceutical Training and Services
Kimberly A. Kew, PhD
Senior Research Scholar
Director, Mass Spectrometry Services