East Carolina University. Tomorrow starts here.®
Department of Chemistry
Anne M. Spuches



East Carolina University

R. A. Skowronsky, M. Schroeter, T. Baxley, Y. Li, J. M. Chalovich, A. M. Spuches. Thermodynamics of Calcium Binding to the Regulatory Site of Human Cardiac TnC: Evidence for Communication with the Structural Calcium Binding Sites.  Journal of Biological Inorganic Chemistry.  Submitted.

C. Sacco, R. A. Skowronsky, S. Gade, J. M. Kenney, A. M. Spuches.  Calorimetric Investigation of Copper (II) Binding to Aβ Peptides:  Thermodynamics of Coordination Plasticity.  Journal of Biological Inorganic Chemistry.17 (4), 531-541, 2012.

A. L. Russell, B. C. Williams, A. Spuches,D. Klapper, A. H. Srouji, and R. P. Hicks.  The Role Played by Charge Density and Proximity to the Peptide Backbone on the Binding Interactions that Occur between Antimicrobial Peptides Containing Unnatural Amino Acids and Zwitterionic and Anionic Liposomes.  Bioorganic Medicinal Chemistry.  Accepted  2012.

A. L. Russell, A. M. Spuches, B.C. Williams, D. Venugopal,  D. Klapper, A. H. Srouji, and R. P. Hicks.   The Effect of the Placement and Total Charge of the Basic Amino Acid Clusters on Antibacterial Organism Selectivity and Potency.  Bioorganic Medicinal Chemistry.  19, 7008-7022, 2011.

A. L. Russell, A. M. Kennedy, A. M. Spuches, W. S. Gibson,  D. Venugopal,  D. Klapper, A. H. Srouji, J.B. Bhonsle and R. P. Hicks.  Determining the Effect of the Incorporation of Unnatural Amino Acids into Antimicrobial Peptides on the Interactions with Zwitterionic and Anionic Membrane Model Systems.  Chemistry and Physics of Lipids, 164, 740-758, 2011.

S. Siamakpour-Reihani, A. M Bradford, T. A. Peterson, H. J. Argiros, L. L. Haas, S.N. Lor, Z. M. Haulsee, A. M. Spuches, D. L. Johnson, L. R. Rohrschneider, C. B. Shuster and B. A. Lyons.  Grb7 Binds to Hax-1 and Undergoes an Intramolecular Domain Association that Offers a Model for Grb7 Regulation.  Journal of Molecular Recognition, 24 (2), 314-321, 2011  

N. E. Grossoehme, A. M. Spuches, D. E. Wilcox. Application of isothermal titration calorimetry in bioinorganic chemistry.  Journal of Biological Inorganic Chemistry. 15 (8), 1183-1191, 2010.

A. L. Russell, A. M. Kennedy, A. M. Spuches, D. Venugopal  and R. P. Hicks.  Spectroscopic and Thermodynamic Evidence for Antimicrobial Peptide Membrane Selectivity.  Chemistry and Physics of Lipids.  163, 488-497, 2010.

J. V. Gavette, J. M. McGrath, A. M. Spuches, A. L. Sargent and W. E. Allen.  Fluorous Effects in Amide-Based Receptors for Anions.  Journal of Organic Chemistry. 74 (10), 3706-3710, 2009.

Previous Publications

A. M. Spuches and D. E. Wilcox.  Monomethylarsenite Competes with Zn2+ for Binding Sites in the Glucocorticoid Receptor.  Journal of the American Chemical Society, 130 (26): 8148-8149, 2008.

A. M. Spuches, H. J. Argiros, K. H. Lee, L. Lowell Haas, S.C. Pero, D. N. Krag, P. P. Roller, D. E. Wilcox and B. A. Lyons.  Calorimetric Investigation of Phosphorylated and non-Phosphorylated Peptide Ligand Binding to the Human Grb7-SH2 Domain.  Journal of Molecular Recognition, 20 (4): 245-252, 2007.

A. M. Spuches, H.G. Kruszyna, A. M. Rich, and D. E. Wilcox. Thermodynamics of As(III)-Thiol Interaction: Arsenite and Monomethylarsenite Complexes with Glutathione, Dihydrolipoic Acid and Other Thiol Ligands.  Inorganic Chemistry, 44 (8): 2964-2972, 2005.

M. Ivancic, A. M. Spuches, E. Guth, M. Daugherty, D. E. Wilcox and B. A. Lyons.  Backbone Nuclear Relaxation Characteristics and Calorimetric Investigation of the Human Grb7-SH2/erB2 Peptide Complex.  Protein Science, 14 (6): 1556-1569, 2005.

M. Chung, X.Gu, B. A. Etzenhouser, A. M. Spuches, P. T. Rye, S. K. Seetharaman, D. Rose, J. Zubieta, M. B. Sponsler.  Intermetal Coupling in [(η5-C5R5)Fe(dppe)]2 (µ-CH=CHCH=CH) and in their Dicationic and Monocationic Mixed-valence Forms.  Organometallics. 22 (17): 3485-3494, 2003.