Associate Professor, Department of Chemistry
Adjunct Associate Professor, Department of Pharmacology and Toxicology
Office: Science and Technology Building 591
Phone: (252) 328-9766
Analytical chemistry research in the Danell lab is focused on fundamental studies and applications of mass spectrometry technology. Mass spectrometry analysis occurs in a unique environment because there is no water or other solvent surrounding the molecules inside a mass spectrometer. We are particularly interested in learning more about gas phase structure to further the application of mass spectrometry to problems of biological significance. Project areas include:
Wentz, W.P.**, Danell, A.S. "Improving the Reliability of Mass Spectrometry Measurements of Peptide-Zinc(II) Binding Constants." Int. J. Mass Spectrom. 2017, 421, 124-128.
Soliman, E., Henderson, K.L.**, Danell, A.S., and Van Dross, R. "Arachidonoyl-ethanolamide Activates Endoplasmic Reticulum Stress-Apoptosis in Tumorigenic Keratinocytes: Role of Cyclooxygenase-2 and Novel J-series Prostamides." Mol. Carcinog. 2016, 55, 117-130. DOI:10.1002/mc.22257
Ellison, M.L., Farrow III, J.M., Parrish, W.A.**, Danell, A.S., and Pesci, E.C. "The Transcriptional Regulator Np20 is the Zinc Uptake Regulator in Pseudomonas aeruginosa." PLoS One. 2013, 8, e75389.
Satterwhite, J. E.**; Trumbo, C. M.**; Danell, A. S.; Hvastkovs, E. G. "Electrochemical Study on the Effects of Epigenetic Cytosine Methylation on Anti-Benzo[a]pyrene Diol Epoxide Damage at TP53 Oligomers." Anal. Chem. 2013, 83, 1183-1191.
Satterwhite, J. E.**; Pugh, A. M.*; Danell, A. S.; Hvastkovs, E. G. "Electrochemical Detection of anti-Benzo[a]pyrene Diol Epoxide DNA damage on TP53 Codon 273 Oligomers", Anal. Chem. 2011, 83, 3327-3335.
Myer, M. J.**; Danell, R. M.; Danell, A. S. "A Simple Dual Polarity Dual nanoElectrospray Ionization Source for Ion/Ion Reactions", Rev. Sci. Instrum. 2010, 81, 066103.
Mattapalli, H.**; Monteith, W. B.*; Burns, C. S.; Danell, A. S. "Zinc Deposition During ESI-MS Analysis of Peptide-Zinc Complexes", J. Am. Soc. Mass Spectrom. 2009, 20, 2199-2205.
Romack, T. J.; Danell, A. S.; Cottone, T. M.*; Dutta, S. K. "Electrospray Ionization Time of Flight Mass Spectrometry Characterization of Perfluoroalkyl Acrylic Oligomers", Rapid Commun. Mass Spectrom. 2008, 22, 930-934.
Unnithan, A. G.*; Myer, M. J.**; Veale, C. J.*; Danell, A. S. "MS/MS of Protonated Polyproline Peptides: The Influence of N-terminal Protonation on Dissociation", J. Am. Soc. Mass Spectrom. 2007, 18, 2198-2203.
Wilson, C. L.**; Monteith, W. B.*; Danell, A. S.; Burns, C. S. "Purification and Characterization of the Central Segment of Prothymosin-a: Methodology for Handling Highly Acidic Peptides", J. Peptide Sci. 2006, 12, 721-725.
* ECU undergraduate student ** ECU graduate student
J-series prostaglandin-ethanolamides as novel therapeutics. US Patent 9,328,060, May 3, 2016.