Art A. Rodriguez
Professor, Physical and Biophysical Chemistry
|1999 - current||Director of Graduate Studies|
|2005 - 2006||Interim Chair of the Department of Chemistry|
|1987||Ph.D., University of North Texas|
|1982||B. S., Sul Ross State University|
We are employing fullerenes as model systems to probe molecular dynamics and complexation properties with macromolecules of biological significance. These studies are also being used to develop a universal model for describing molecular dynamics in liquids.
Our group is currently utilizing quantum dots to develop biosensors for diagnostic purposes. The diagnostic technique currently being used to test for prostate cancer (CaP) is dependent on detecting prostate-specific antigen (PSA) levels in the serum. This diagnostic protocol is however limited since frequently it can not differentiate between CaP and benign prostate hyperplasia (BPH). The recent discovered correlation between the over-expressed protein d-catenin and the occurrence of prostate cancer (CaP) provides a unique opportunity for developing a specific diagnostic essay based on this correlation. The scientific question we are addressing in the initial phase of this project is the feasibility of developing a QD-biosensor that is robust, sensitive, and highly selective toward detecting the d-catenin protein.
“Experimental and theoretical analysis of the
dynamics of fullerene C70 in various aromatic environments,” R. M. Hughes
and A. A. Rodriguez, J. Phys. Chem. A, submitted.
“Comparison of and investigation into the size
affects on the rotational dynamics of two spherical molecules: CCl4
and C60,” K. B. Nichols and A. A. Rodriguez, J. Phys. Chem. A, 109 (13), 3009 (2005).
“Field Dependent Relaxation and Molecular Dynamics of
C60 in Chlorobenzene-d5: Addendum,” N. H. Martin and
A. A. Rodriguez, J. Phys. Chem. A, 109 (03), 534 (2005).
“Analysis of the Spin-Lattice Relation Rate and
Reorientational Dynamics of Fullerene C70 in Chlorobenzene-d5,”
R. M. Hughes, P. Mutzenhardt, L. Bartolotti, and A. A. Rodriguez, J. Mol.
Liq., 116, 139, (2005).
Relaxation and Molecular Dynamics of C60 in Chlorobenzene-d5,”
Ned H. Martin, Mervat H. Issa* and A. A. Rodriguez, J. Phys. Chem., 104
(48), 11278, (2000).
“Monoclonal Antibody DS6 Detects a Tumor-Associated Sialoglycotope Expressed on Human Serous Ovarian Carcinomas,” K. P. Kearse, N. L. Smith, D. A. Semer, L. Eagles, J. L. Finley, S. Kazmierczak, C. J. Kovacs, A. A. Rodriguez and A. E. Kellogg-Wennerberg, Int. J. Cancer, 88, 866, (2000).
Department of Chemistry
East Carolina University
300 Science & Technology Building
Greenville, NC 27858