Useful Links

Research Interest:

Dr. Huang brings strong expertise inphysics, computer programming and the Monte Carlo (MC) simulations based on Geant4 libraries. He applied his computer programming skills to medical imaging modalities such as PET/MRI and improved the image reconstruction system.The MC simulation is very useful in the field of radiation therapy because it would help optimize the dose profiles and thus improve the design of treatment planning of radiation therapy. His current research topic includes the MC simulation for implanted seeds in tumor for bachytherapy.

Inhisrecent project of outcome prediction for cervical cancer, a kinetic model was developed to simulate the regression rate of tumor volumes measured by using magnetic resonance imaging, resulting in radiobiological parameters which mostly reflect multiple interrelated biologic processes that influence cell metabolism


Dr. Zhibin Huang

HuangZhibin
  • Assistant Professor
  • PhD., Case Western Reserve University, May 2008,
  • Office Location: Austin 118
  • Office Hours: Tuesday and Thursday 2:00pm -5:30pm
  • Telephone: (252) 744-3768
  • Email: huangz@ecu.edu

Publications:

Huang Z, Mayr NA, Lo SS,Yuh WTC,Wang JZ. Repair kinetics deduced from multifractioned irradiation regimen in mouse lung–application of the gLQ model. (submitted)

Zhang C, Mayr NA, Lo SS, Lu L, Li K, Zheng Y, Yuh WTC, Wang JZ,Huang Z. Is theα/βratio Dose-Range dependent? (submitted)

Huang Z, Mayr NA,Grecula JC,et al.Response modeling in cervical cancer: how early can we predict the outcome of radiation therapy?(submitted)

Berber B, Sanabria JR, Yao M, Ellis RJ, Kunos CA, Sohn J, Machtay M, Teh BS,Huang Z, Mayr NA, LoSS,STEREOTACTIC BODY RADIOTHERAPY (SBRT) IN THE TREATMENT OF PANCREATIC CANCER,Expert Review of Anticancer Therapy(Accepted)

Song A, Shiue K, Machtay M, Yao M, Ellis RJ,Huang Z, Mayr NA, Teh BS, Lo SS. Stereotactic body radiation therapy for metastasis in the lung: An undervalued treatment option with future prospects.Lung Cancer Management,1(1):73-79 (2012)

Huang Z, Mayr NA, Lo SS, Grecula JC, Wang JZ, Jia G, Yuh WTC. Characterizing At-Risk Voxels by Using Perfusion MRI for Cervical Cancer during Radiotherapy.J Cancer Sci Ther4: 254-259. doi:10.4172/1948-5956.1000151 (2012)

Huang Z, Mayr NA, Gao M, Lo SS, Wang JZ,Yuh WTC. The onset time of tumor repopulation for cervical cancer–first evidence from clinical data.Int J Radiat Oncol Biol Phys,84(2):478(2012)

Lo SS,RadawskiJD, Nelson A, Clarke JW, McGregor JM, Mayr NA, Cavaliere R, Wang JZ,Huang Z, Grecula JC. Stereotactic radiosurgery with or without whole brain radiotherapy for patients with 1 to 3 melanoma brain metastases.J Radiat Oncol1:73-79 (2012)

Mayr NA,Huang Z,Wang JZ,et al.Characterizing tumor heterogeneity with functional imaging and quantifying high-risk tumor volume for early prediction of treatment outcome: cervical cancer as a model. In press,Int J Radiat Oncol Biol Phys83(3):972-979(2012)

Lo SS, Teh BS, Mayr NA, Chiang SB,Huang Z,YaoM, Machtay M.Imaging Follow-up after Stereotactic Ablative Radiotherapy (SABR) For Lung Tumors.J Radiat Oncol1:11-16 (2012)

RadawskiJD,Huang Z,Wang JZ, Yuh WTC,Mayr NA.A novel method of longitudinal image fusion and tumor delineation on sagital MRI sequences for image-guided brachytherapy.Discov Med13(68):47-56 (2012)

Huang Z, Mayr NA, Yuh WTC, Lo SS, Wang JZ, Johnke R. Ageneralized linear-quadratic model with reciprocal time of radiation damage repair.Medical Physics39(1):224-230 (2012)

Huang Z,Mayr NA, Lo SS, Grecule JC,Yuh WTC,Wang JZ. Investigating Predictive Power of At-risk Voxels Using DCE-MRI during Radiotherapy for Cervical Cancer.The International Association of Science and Technology for Development (IASTED), USA, the Proceeding of IASTED International Conference on Imaging and Signal Processing in Healthcare and Technology, May 16-18, Washington, DC, USA (2011)http://www.actapress.com/Content_of_Proceeding.aspx?proceedingID=702

Mayr NA,Huang Z, Sohn JW, Lo SS, Teh BS, Lu JJ, Grecula JC, Kunos C. Emerging application of stereotactic body radiation therapy for gynecologic malignancies.Expert Rev Anticancer Ther. 11(7):1069-1075 (2011)

Siddiqui F, Raben D, Lu JJ, Grecula JC, Lo SS,Huang Z, Mayr NA, Teh BS,YaoM. Emerging Applications of Stereotactic Body Radiation Therapy for Head and Neck Cancer.Expert Review of Anticancer Therapy11(9):1429-1436 (2011)

Lo SS, Teh BS, Wang JZ,Huang Z, Zook J, Price T, Mayr NA, Grecula JC, Timmerman RD, Cardenes HR. Imaging changes after stereotactic body radiation therapy for lung and liver tumors.Expert Rev Anticancer Ther. 11(4):613-620 (2011)

Wang JZ,Huang Z, Lo SS, Yuh WTC, Mayr NA.A generalized linear-quadratic model for radiosurgery, stereotactic body radiation therapy, and high-dose rate brachytherapy.Sci. Transl. Med.2(39):39ra48 (2010)

Wang JZ,Huang Z, Lo SS, Grecula JC, Mayr NA, Yuh WTC. Tumor regression model of cervical cancer-reponse.Cancer Res70:6104 (2010)

Gao M, Mayr NA,Huang Z, Zhang H, Wang JZ, When tumor repopulation starts? The onset time of prostate cancer during radiation therapy.Acta Oncologica49(8):1269-1275 (2010)

Hadziahmetovic M, Loo BW,Timmerman RD, Mayr NA, Wang JZ,Huang Z, Grecula JC, Lo SS. Stereotactic body radiation therapy (stereotactic ablative radiotherapy) for stage I non-small cell lung cancer-updates of radiobiology, techniches, and clinical outcomes.Discov Med9(48):411-417 (2010)

Lo SS,DawsonLA, Kim EY, Mayr NA, Wang JZ,Huang Z, Cardenes HR. Stereotactic body radiation therapy for hepatocellular carcinoma.Discov Med9(48):404-410 (2010)

Huang Z, Mayr NA, Yuh WTC,et al.Predicting outcomes in cervical cancer: a kinetic model of tumor regression during radiation therapy.Cancer Res70:463-470 (2010)

Mayr NA, Wang JZ, Zhang D, Grecula JC, Lo SS, Jarjoura D, Montebello JF, Zhang H, Li K, Lu L,Huang Z, Fowler JM, Wu DH, Knopp MV, Yuh WTC. Longitudinal changes in tumor perfusion pattern during the radiation therapy course and its clinical impact in cervical cancer.Int J Radiat Oncol Biol Phys77(2):502-508 (2010)

Mayr NA, Wang JZ,Huang Z, Zhang D, Yuh WTC. Both hemoglobin and tumor perfusion influence tumor hypoxia: parallels between laboratory and clinic. Reply to Vaupel etal.IJROBP.Int J Radiat Oncol Biol Phys76(3):959 (2010)

Wang JZ,Huang Z, Mayr NA, and Yuh WTC, Behind: In Response to Drs. Mavroidisand Lind,Acta Oncologica,48(4):614-617 (2009)

Huang Z, Luca DA, Atherton TJ, Bird M, Rosenblatt C, and Carlès P,Rayleigh-Taylor instability experiments with precise and arbitrary control of the initial interface shape,Phys. Rev. Lett.99, 204502 (2007)

Kadau K, Rosenblatt C, Barber JL, Germann TC,Huang Z, Carlès P, and Alder BJ, The importance of fluctuations in fluid mixing,Proc. Natl. Acad. Sci.104,7741 (2007)

Carlès P,Huang Z, Carbone G, and Rosenblatt C,Rayleigh-Taylor instability for immiscible fluids of arbitrary viscosities: Magnetic levitation investigation and theoretical model,Phys. Rev. Lett.96,104501 (2006)

Huang Z, Carbone G, Xia C, Sinha GP, and Rosenblatt C,Smectic tilt susceptibility:Anharmonic behavior in surface-induced smectic layers above the nematic--smectic-A transition temperature,Phys. Rev. E72, 021708 (2005)

Huang Zand Rosenblatt C,Large polar pretilt for the liquid crystal homologous series alkycyanobiphenyl,Appl. Phys. Lett.86,011908 (2005)

Chen Y andHuang Z,Resonance, Chaos and Halo Formation in Space Charge Dominated Beams,High Energy Physics and Nuclear Physics,24(6):560-566 (2000) (in Chinese)

Chen Y andHuang Z,Nonlinear Resonance and Halo Formation Induced by Space Charge,Atomic Energy Science and Technology,34(4):289-295 (2000) (in Chinese)

Huang Zand Chen Y, Halo Formation in Breathing Round Beam in a Periodic Focusing Channel,Atomic Energy Science and Technology,33(5):385-391 (1999) (in Chinese)

Chen Y andHuang Z, Nonlinear Space Effects and Emittance Growth in Linac,High Energy physics and Nuclear Physics,23(12):1231-1242 (1999) (in Chinese)

Chen Y andHuang Z, Relation between beam emittance and brightness with density distributions,Atomic Energy Science and Technology,33(2):170-174 (1999) (in Chinese)

Chen Y andHuang Z, Variation of geometry factor with the density distribution of bunched beam in LINAC,Chinese Journal of Nuclear Science and Engineering,19(1):76-79 (1999) (in Chinese)

Chen Y andHuang Z, Resonances and halo formation of space charge dominated beams in periodic focusing channels,Chinese Journal of Nuclear Science and Engineering,20(1):70-77 (1999) (in Chinese)

Huang Zand Chen Y, the Proc. of the 1998 LINAC Conference,Chicago, August, 1998, pp.147,http://accelconf.web.cern.ch/AccelConf/l98/PAPERS/MO4044.PDF

Chen Y andHuang Z, the Proc. of the 1998 LINAC Conference,Chicago, August, 1998, pp.753,http://accelconf.web.cern.ch/AccelConf/l98/PAPERS/TH2005.PDF

Huang Z and Chen Y, Simulation of Halo Formation in Breathing Round Beams in a Uniform or Periodic Focusing Channel,High Energy physics and Nuclear Physics,22(10):943-950 (1998) (in Chinese)

Chen Y andHuang Z, Coupling envelope equations for bunched beam in LINAC,Atomic Energy Science and Technology,32(5):391-394 (1998) (in Chinese)

Fu S, Chen Y,Huang Z, Integrated numerical experiment of an intense RF LINAC for CIAE Far-Inrared FEL,Chinese Journal of Nuclear Physics19(2):121-127 (1997)

Huang Z, Chen Y, Fu S, Free energy and emittance growth caused by longitudinal Gaussian distribution combined with different transverse distributions in LINAC,Chinese Journal of Nuclear Science and Engineering17(3):242-249 (1997) (in Chinese)

Chen Y,Huang Z, Fu S, Scaling Law of Emittance Growth for Bunched Beam with Gaussian Density Distribution in Both Longitudinal and Transverse Directions in LINAC,High Energy Physics and Nuclear Physics21(7):657-663 (1997) (in Chinese)

Fu S, Chen Y,Huang Z, Simulation study on the accelerator noise effect on the far-infrared FEL oscillator,High Power Laser and Particle Beams9(1):7-12, 1997 (in Chinese)

Huang Z, Chen Y, Fu S, Emittance growth caused by nonuniform space charge distributions of bunched beam in linac,Atomic Energy Science and Technology30(2):103-111 (1996) (in Chinese)

Huang Z, Chen Y, Fu S, Free energy and emittance growth caused by bunched beam with Gaussian distribution in longitudinal direction in LINAC,Chinese Journal of Nuclear Physics18(4):236-243 (1996)

Chen Y,Huang Z, Fu S, Difference of Field Energy of a Bunched Beam Induced by Beam-Pipe Size Changes,High Energy Physics and Nuclear Physics20(6):571-576 (1996) (in Chinese)

Huang Z, Chen Y, Fu S, the Proc. ofthe1996InternationalLINACConference, pp.375

Huang Z, Chen Y, Fu S, Free energy and emittance growth caused by bunched beam with nonuniform distributions in both longitudinal and transverse directions in LINAC,Chinese Journal of Nuclear Physics17(4):345-352 (1995)

Chen Y, Fu S,Huang Z, Zhang Z,Space charge effect of bunched beam with nonuniform distribution in both longitudinal and transverse directions,Chinese Journal of Nuclear Physics17(1):81-88 (1995)

Chen Y, Fu S,Huang Z,Zhang Z,Space charge effect of bunched beam with Gaussian distribution,Chinese Journal of Nuclear Physics17(2):174-178 (1995)

Fu S, Chen Y,Huang Z, IEEE PAC95 Proceedings,http://epaper.kek.jp/p95/INDEX.html, pp.237

Huang Z, Chen Y, Fu S, IEEE PAC95 Proceedings,http://epaper.kek.jp/p95/INDEX.html, pp.3346

Chen Y, Fu S,Huang Z, Zhang Z,IEEE PAC95 Proceedings,http://epaper.kek.jp/p95/INDEX.html, pp. 3343

Chen Y, Fu S,Huang Z,Zhang Z,Nonlinear space charge effect of bunched beam with Gaussian type longitudinal distribution,Atomic Energy Science and Technology,29(2):115-119 (1995) (in Chinese)

Chen Y, Fu S,Huang Z,Zhang Z,Space charge effect of bunched beam with nonuniform distribution in both longitudinal and transverse directions,Atomic Energy Science and Technology,28(6):481-487 (1995) (in Chinese)

PEER-REVIEWED ABSTRACTS

Huang Z, Mayr NA, Yuh WTC, Sahgal A, Wang JZ, Lo SS,Re-irradiation With Stereotactic Body Radiotherapy (SBRT): Analysis Of Human Spinal Cord Tolerance Using The Generalized Linear-quadratic Model.Int J Radiat Oncol Biol Phys, accepted(2012)

Huang Z, Mayr NA, Yuh WTC, Wang JZ, Lo SS,The Kinetics of Repair of Sublethal Damage in Rat Cervical Spinal Cord during Fractionated Irradiation - Application of the gLQ Model with Reciprocal Time Pattern.Int J Radiat Oncol Biol Phys,accepted(2012)

Mayr NA,Huang Z, Jia G, Zhang J, Grecula JC, Lo SS, Yuh WTC,Low-perfusion Tumor Subvolumes, Assessed by the Heterogeneity Functional Risk Volume Method, and Treatment Outcome in Cervical Cancer: Does Hemoglobin Matter?Int J Radiat Oncol Biol Phys, accepted(2012)

Yuh WTC,Huang Z, Lo SS, Grecula JC, Mayr NA, Biological Equivalent Dose (BED) - Application of the Generalized Linear-Quadratic Model for Spinal SBRT.J Radiat Oncol Biol Phys,accepted(2012)

Z. Huang, N. Mayr, S. Lo, J. Sattler, T. Liu, D. Zhang, G. Jia, L. Lu, H. Zhang, and W. Yuh, Kinetics of Repair Deduced From Multi-Fractioned Irradiation Regimen in Mouse Lung Application of the gLQ Model,Med Phys,39(6):3994 (2012)

Z. Huang, N.A. Mayr, S.S. Lo,R. McLawhorn, M. Gao, T. Liu, and W. Yuh, Repair Kinetics of Sublethal Damage in Rat Cervical Spinal Cord - Application of the gLQ Model Incorporating Reciprocal Time Pattern.Med Phys,39(6):3703 (2012)

T. Liu, P. Rajaguru, G. Dieck, J. Edwards, R. He, Z. Huang,S. Vijayakumar, and C. Yan, Variation in VMAT QA Pass Rate Caused by Detector Setup Errors,Med Phys,39(6):3784 (2012)

T. Liu, R. He,Z. Huang, and S. Vijayakumar, and C. Yang, Comparison of Three Array Calibration Methods of MapCheck for Elekta Beam Modulator LINAC,Med Phys,39(6):3786 (2012)

Huang Z, Tung C, Hu Z, Wu Y, Zhu M, Brown R, Mayr N, Yuh WTC, Lo SS. Monte-Carlo-Based Scatter Analysis for Improving Reconstruction of PET/CT Systems.Med Phys.38(6):3436 (2011)

Huang Z, Mayr NA, Yuh WTC, Lo SS, Gao M, A Generalized Linear-Quadratic Model Incorporating Reciprocal Time of Radiation Damage Repair.Med Phys.38(6):3486 (2011)

Huang Z, Mayr NA, Lo SS, Yuh WTC, Wang JZ, Synergistic Effect of Radiobiological Parameters in Predicting Outcomes during Radiation Therapy for Cervical Cancer.Int J Radiat Oncol Biol Phys81:S28(2011)

Huang Z, Mayr NA, Lo SS, Grecula JC, Wang JZ, Yuh WTC, Temporal Changes in Tumor Regional Perfusion Patterns and Treatment Outcome in Cervical Cancer.Int J Radiat Oncol Biol Phys81:S756(2011)

Mayr NA,Huang Z, Lo SS, Jia G, Grecula JC, Zhang J, Fan JM, Knopp MV, Yuh WTC, Therapy Outcome Prediction of Cervical Cancer with the Regression Rate of Physiologic High-Risk Tumor Subvolume Assessed by DCE MRI.Int J Radiat Oncol Biol Phys81:S47(2011)

Mayr NA,Huang Z, Eisenhauer E, Lo SS, Wang JZ, Yuh WTC, Postoperative seromas following robostic/aparoscopic lymph node dissection in patients with radiation/chemotherapy for gynecologic cancers .Int J Radiat Oncol Biol Phys81:S462(2011)

Yuh WTC,Huang Z, Jia G, Lo SS, Zhang J, Wang JZ, Zhang D, Shah ZK, Mayr NA, Optimal Classification to Characterize Tumor Heterogeneity and At-Risk Tumor Voxels by DCE MRI for Early Prediction of Therapy Outcome.Int J Radiat Oncol Biol Phys81:S158(2011)

Lu L,Gupta N,Zhang D,Weldon M,Wang J, Zhang H,Sundararaman I, andHuang Z,The Comparison of Matrixx IMRT QA and MapCheck EMRT QA.Med Phys37:3243 (2010)

Wang JZ,Huang Z, Lo SS, Yuh WTC, and Mayr NA, The Puzzle of Repair Half-Time in Mouse Lung Irradiation – Application of the gLQ Model.Med Phys37:3349 (2010)

Huang Z, Mayr NA, Yuh WTC, Lo SS, and Wang JZ, Combining Model Parameters – Radiosensitivity and Dead-Cell Resolving Time to Predict Outcome of Radiation Therapy for Cervical Cancer.Med Phys37:3355 (2010)

Wang JZ,Huang Z, Lo SS, Grecula JC, Yuh WTC, Mayr NA, Patient Specific TCP – A Strong Outcome Predictor for Radiation Therapy of Cervical Cancer,Int J Radiat Oncol Biol Phys78:S47 (2010)

Barman SL,Huang Z, Mayr NA, Quick A, Lo SS, Wang JZ, Impact of Dose Heterogeneity on Modeling Prostate Cancer Brachytherapy,Int J Radiat Oncol Biol Phys78:S48 (2010)

Yuh WTC,Huang Z, Mayr NA, Lo SS, Wang JZ, Hemoglobin Influences Tumor Cell Radiosensitivity in Patients with Cervical Cancer,Int J Radiat Oncol Biol Phys78:S119 (2010)

Mayr NA, Wang JZ,Huang Z, Lo SS, Fan JM, Grecula JC, Sammet S, Tosti CL, Knopp MV, Yuh WTC,Quantifying Absolute Functional Risk Volume with Functional Tumor Imagingfor Treatment OutcomePrediction in Cervical Cancer,Int J Radiat Oncol Biol Phys78:S142 (2010)

Huang Z, Mayr NA, Lo SS, WTC Yuh, Jia G, Tosti CL, Sammet S, Wang JZ,Inter-patient Variation of Radiosensitivity and Dead-cell Resolving Time in Cervical Cancer,Int J Radiat Oncol Biol Phys78:S411 (2010)

Huang Z, Mayr NA Yuh WTC, Lo SS, Montebello JF, Lu L, Li K, Zhang H, Gupta N, Wang JZ.JUNIOR INVESTIGATOR WINNER:Outcome prediction of cervical cancer: kinetic model of tumor regression during radiation therapy,Med Phys36:2721(2009)

Huang Z, Mayr NA, Gao M, Zhang D, Yuh WTC, and Wang JZ.Onset Time of Tumor Repopulation for Cervical Cancer–First Evidence from Clinical Data,Int J Radiat Oncol Biol Phys75:S46 (2009)

Wang JZ, Mayr NA,Huang Z, Lu L, Zhang D,MontebelloJF, Lo SS, and Yuh WTC.The Mechanism behind Tumor Regression during Radiation Therapy of Cervical Cancer,Int J Radiat Oncol Biol Phys75:S47 (2009)

Mayr NA,Huang Z, Yuh WTC, Li K,MontebelloJF, Grecula JC, Lo SS, and Wang JZ.Response Modeling in Cervical Cancer: How Early Can We Predict the Outcome of Radiation Therapy?,Int J Radiat Oncol Biol Phys75:S86 (2009)

Yuh WTC, Wang JZ,Huang Z, Li K, Sammet S, Liang J, Lu L, Knopp MV, and Mayr NA. MRI-guided Brachytherapy for Cervical Cancer – Is Dynamic Contrast Enhanced MRI Useful?,Int J Radiat Oncol Biol Phys75:S123 (2009)

Zhang D, Mayr NA, Yuh WTC, Lo SS, Grecula JC,Huang Zand Wang JZ. Topography of Perfusion within the Tumor: Impact of the Differential Distribution of Perfusion on Metastatic Failure in Cervical Cancer,Int J Radiat Oncol Biol Phys75:S150 (2009)

Gao M,Huang Z, Mayr NA, Wang JZ. Tumor Repopulation during Radiation Therapy – Stage Dependency of Onset Time for Prostate Cancer,Int J Radiat Oncol Biol Phys75:S349 (2009)

Huang Z, Mayr NA, Gao M, Yuh WTC, and Wang JZ.Onset time of tumor repopulation for cervical cancer,Ohio River Valley and Penn-Ohio Chapters of the AAPM(2009)

Lu L, Yembi-Goma G, Wang J, Gupta N, Li K, Zhang H, Weldon M,Huang Z, Lo SS, Martin D, Mayr NA. A Practical Method to Measure and Evaluate Different Dose Calculation Algorithms in Varian Eclipse Treatment Planning System.Med Phys,36:2597 (2009)

Wang JZ,Huang Z, Gao M, Lo SS, Yuh WTC, Mayr NA. When Tumor Repopulation Starts? An Outcome Analysis of Radiotherapy for Cervical Cancer.Med Phys,36:2637 (2009)

Rahman A,MontebelloJF, Lu L, Gupta N,Huang Z, Mayr NA, Wang JZ. To Reduce Hot Spots in Craniospinal Irradiation: A Two-Field IMRT Approach with Matching Beam Divergence,Med Phys,36:2658 (2009)

BOOK CHAPTER

·Huang Z, Mayr NA, Lo SS, Yuh WTC, Radiobiology of Stereotactic Body Radiation Therapy (SBRT),Future Science Group(2013).

·Lo SS, Sahgal A, Kunos CA, Teh BS, Yao M, Machtay M, Mayr NA,Huang Zand Chang EL, Reported toxicities associated with stereotactic body radiation therapy.In: Stereotactic Body Radiation Therapy. (Eds: Simon S. Lo, Bin S. Teh, Jiade J. Lu, Tracey E. Schefter)Springer2013.

·Lo SS, Sahgal A, Ma J, Slotman B,Huang Z, Mayr NA, Kunos CA, Teh BS, Machtay M, Chang EL,Normal tissue constraints. In: Stereotactic Body Radiation Therapy. (Eds: Simon S. Lo, Bin S. Teh, Jiade J. Lu, Tracey E. Schefter)Springer2013.

·Mayr NA,Huang Z, Lo SS, Yuh WTC, Magnetic Resonance Imaging for Assessing Tumor Response in Cervical Cancer.Radiation Medicine Rounds2:3 (2011) 449–462