Experimental and theoretical study of light interaction with biological tissues and cells; optical imaging of turbid medium; flow cytometry.
Dong, K., Feng, Y., Jacobs, K. M. , Lu, J. Q. , Brock, R. S. , Li V. Yang, Fred E. Bertrand, Mary A. Farwell,
Xin-Hua Hu, (2011). Label-free classification of cultured cells through diffraction imaging.
Biomedical Optics Express, 2 (6), 1717-1726. >
Gkigkitzis, I., Feng, Y., Yang, C., Lu, J. Q. , &
Hu, X. H. (2012). Modeling of Oxygen Transport and Cell Killing in Type II Photodynamic Therapy.
Photochemistry and Photobiology, 88. >
Hu, X. H., & Lu, J. Q. (2012). Correlating the light scattering pattern of a biological cell to its mitochondrial properties using a Gabor filter technique.
Ding, J., Wu, T., Xu, D., Lu, J. Q. , &
Hu, X. H. (2011). Metamorphic Testing of a Monte Carlo Modeling Program.
Proceedings of the 6th International Workshop on Automation of Software Test, ACM, 1-7.
Dong, K., Jacobs, K. M., Sa, Y., Feng, Y., Lu, J. Q. ,
X.H. Hu, (2011). Study of Cell Classification with a Diffraction Imaging Flow Cytometer Method.
SPIE Photonics West.
Jacobs, K.M., Lu, J.Q., &
Hu, X.H. (2009). Development of a diffraction imaging flow cytometer.
Optics Letters, 34, 2985-2987.
Jacobs, K.M., Yang, L.V., Ding, J., Ekpenyong, A.E., Castellone, R., J.Q. Lu,
X.H. Hu, (2009). Diffraction imaging of spheres and melanoma cells with a microscope objective.
Journal of Biophotonics, 2, 521527.
(for more details, please go to
Biomedical Laser Laboratory)
X.H. Hu, H. Jiang,
"A higher order diffusion model for three-dimensional photon migration and image reconstruction in optical tomography",
Physics in Medicine and Biology, 54, 67-90 (2009)
J.Q. Lu, C. Chen, D.W. Pravica, R.S. Brock,
"Validity of a closed-form diffusion solution in P1 approximation for reflectance imaging with an oblique beam of arbitrary profile",
Medical Physics, 35, 3979-3987 (2008)
J.Q. Lu, R. S. Brock, P. Yang,
X.H. Hu, "Modeling of light scattering by single red blood cells with a FDTD method", in
Optics of Biological Particle
, ed. by A. Hoekstra, G. Videen and V. Maltsev (Springer, 2007)
C. Chen, J.Q. Lu, K. Li, S. Zhao, R.S. Brock,
"Numerical study of reflectance imaging using a parallel Monte Carlo method",
Medical Physics, 34, 2939-2948 (2007)
H. Ding, J.Q. Lu, R.S. Brock, T.J. McConnell, J.F. Ojeda, K.M. Jacobs,
"Angle-resolved Mueller matrix study of light scattering by B-cells at three wavelengths of 442, 633 and 850 nm",
Journal of Biomedical Optics, 12, 034032 (2007)
X.H. Hu, W. Tang, K. Li, J.Q. Lu, "Transgenic plants with efficient laser-mediated gene transformation and multispectral imaging based rapid monitoring", in
Genes, Genomes and Genomic, vol. , ed. by D. Thangadurai, W. Tang and T. Pullaiah (Regency Publications, 2006)
W. Tang, D.A. Weidner, B.Y. Hu, R.J. Newton,
"Efficient delivery of small interfering RNA to plant cells by a nanosecond pulsed laser-induced stress wave for posttranscriptional gene silencing",
Plant Science, 171, 375-381 (2006)
C. Chen, J.Q. Lu, H. Ding, K.M. Jacobs, Y. Du,
"A primary method for determination of optical parameters of turbid samples and application to intralipid between 550 and 1630 nm",
Optics Express, 14, 7420-7435 (2006)
R. S. Brock,
X.H. Hu, D.A. Weidner, J.R. Mourant, J.Q. Lu,
"Effect of detailed cell structure on light scattering distribution: FDTD study of a B-cell with 3D structure constructed from confocal images",
Journal of Quantitative Spectroscopy & Radiative Transfer, 102, 25-36 (2006)
H. Ding, J.Q. Lu, W.A. Wooden, P.J. Kragel,
"Refractive indices of human skin tissues at eight wavelengths and estimated dispersion relations between 300 and 1600 nm",
Physics in Medicine and Biology, 51, 1479-1489 (2006)
X.H. Hu, J.Q. Lu, "Optical detection of cancers", in Encyclopedia of Biomaterials and Biomedical Engineering, ed. by G.E. Wnek and G.L. Bowlin (Marcel Dekker, 2006)
X. H. Hu, Y. Feng, J.Q. Lu, R.R. Allison, R.E. Cuenca, G.H. Downie, C.H. Sibata, "Modeling of a Type II Photofrin-Mediated Photodrama Therapy Process in a Heterogeneous Tissue Phantom", Photochemistry and Photobiology, 81, 1460-1468 (2005)
X. H. Hu, "Laser Application in Plant Biotechnology", in Biotechnology for Food, Agriculture and Environment, ed. by D. Thangadurai et al. (Regency Publications, 2005)
X.H. Hu, P. Yang, J.Q. Lu, "Evaluation of a parallel FDTD code and application to modeling of light scattering by deformed red blood cells",
Optics Express, 13, 5279-5292 (2005)
Y. Feng, R.R. Allison,
X.H. Hu, H. Mota, T. Jenkins, M.L. Wolfe, C.H. Sibata, "An Ultrasonic Device for SSD Measurement in Patient Setup",
International Journal of Radiation Oncology, Biology, Physics, 61, 1587-1589 (2005)
H. Ding, J.Q. Lu, K.M. Jacobs,
X.H. Hu, "Determination of Refractive Indices of Porcine Skin Tissues and Intralipid at 8 Wavelengths between 325 and 1557nm" ,
Journal of the Optical Society of America A, 22, 1151-1157 (2005)
J.Q. Lu, P. Yang,
X.H. Hu, "Simulations of Light Scattering from a Biconcave Red Blood Cell Using the FDTD method' ,
Journal of Biomedical Optics, 10 (2), 024022 (2005)
X. Ma, J.Q. Lu, H. Ding,
X.H. Hu, "Bulk Optical Parameters of Porcine Skin Dermis Tissues at 8 Wavelengths from 325 to 1557 nm" ,
Optics Letters, 30, 412-414 (2005)
R.R. Allison, C. Sibata, T.S. Mang, V.S. Bagnato, G.H. Downie,
X.H. Hu, R. Cuenca, "Photodynamic therapy for chest wall recurrence from breast cancer" ,
Photodiagnosis and Photodynamic Therapy, 1, 157-171 (2004)