Research Assistant Professor
office: Brody 7N-94A
B.S., University of North Carolina at Chapel Hill
Ph.D., University of North Carolina at Chapel Hill
Postdoctoral Fellow, Brody School of Medicine at East Carolina University
My research efforts are focused on investigating protein interactions and signaling pathways involving the CD44 cell surface transmembrane type 1 glycoprotein and its interaction with hyaluronan (HA), a critical component of the extracellular matrix. Interestingly, both CD44 and HA are found in articular chondrocytes and are involved in the joint cartilage degenerating disease, osteoarthritis.
Taken as a whole, I would like to understand the biological relevance and consequences of the interaction between CD44, hyaluronan and the cellular microenvironment. This knowledge will not only improve our basic understanding of the mechanism of actions underlying extracellular matrix homeostasis and degeneration, but also hopefully provide a platform for developing novel anti-osteoarthritic therapies with the potential to improve the clinical outcome of arthritis sufferers.
Askew, E.B., R.T. Gampe, Jr., T.B. Stanley, J.L. Faggart, and E.M. Wilson. 2007. Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone. J. Biol. Chem. 282: 25801-25816.
Askew, E.B., S. Bai, A.T. Hnat, J.T. Minges, and E.M. Wilson. 2009. MAGE-11 F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators. J. Biol. Chem. 284: 34793-34808.
Askew, E.B., S. Bai, A.J. Blackwelder, and E.M. Wilson. 2010. Transcriptional synergy between melanoma antigen protein-A11 (MAGE-11) and p300 in androgen receptor signaling. J. Biol. Chem. 285: 21824-21836.
Askew, E.B., J.T. Minges, A.T. Hnat, and E.M. Wilson. 2012. Structural features discriminate androgen receptor N/C terminal and coactivator interactions. Mol. Cell Endocrinol. 348: 403-410.
Mellor, L., C.B. Knudson, D. Hida, E.B. Askew, and W. Knudson. 2013. Intracellular domain fragment of CD44 alters CD44 function in chondrocytes. J. Biol. Chem. 288: 25838-25850.
Luo N., W. Knudson, E.B. Askew, R.M. Veluci, and C.B. Knudson. 2014. CD44 and hyaluronan promote the bone morphogenetic protein 7 signaling response in murine chondrocytes. Arthritis Rheum. 66:1547-1558.
Ishizuka, S., E.B. Askew, N. Ishizuka, C.B. Knudson, and W. Knudson. 2016. 4-methyl-umbelliferone diminishes catabolically-activated articular chondrocytes and cartilage explants via a mechanism independent of hyaluronan inhibition. J. Biol. Chem. 291: 12087-12104.
Yuang, Y., E.B. Askew, C.B. Knudson, and W. Knudson. 2016. CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention. Matrix Biol. 56: 74-94.
Askew, E.B., S. Bai, A.B. Parris, J.T. Minges, and E.M. Wilson. 2017. Androgen receptor regulation by histone methyltransferase suppressor of variegation 3-9 homolog 2 and melanoma antigen-A11. Mol. Cell Endocrinol. 443: 42-51.
"Transgene Enhancement of Hyaluronan in Osteoarthritic Cartilage" (NIH R21 AR066581); Emily Askew, Co-Investigator; National Institute for Arthritis and Musculoskeletal and Skin Diseases; 8/7/2014-7/31/2017.