Emily B. Askew, Ph.D.

Emily Askew

Research Assistant Professor

office: Brody 7N-94A
phone: 252-744-0310
email: askewe@ecu.edu

B.S., University of North Carolina at Chapel Hill
Ph.D., University of North Carolina at Chapel Hill
Postdoctoral Fellow, Brody School of Medicine at East Carolina University


Research

My research efforts are focused on investigating protein interactions and signaling pathways involving the CD44 cell surface transmembrane type 1 glycoprotein and its interaction with hyaluronan (HA), a critical component of the extracellular matrix. Interestingly, both CD44 and HA are found in articular chondrocytes and are involved in the joint cartilage degenerating disease, osteoarthritis.

Taken as a whole, I would like to understand the biological relevance and consequences of the interaction between CD44, hyaluronan and the cellular microenvironment. This knowledge will not only improve our basic understanding of the mechanism of actions underlying extracellular matrix homeostasis and degeneration, but also hopefully provide a platform for developing novel anti-osteoarthritic therapies with the potential to improve the clinical outcome of arthritis sufferers.


Selected Publications

Askew, E.B., R.T. Gampe, Jr., T.B. Stanley, J.L. Faggart, and E.M. Wilson. 2007. Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone. J. Biol. Chem. 282: 25801-25816.

Askew, E.B., S. Bai, A.T. Hnat, J.T. Minges, and E.M. Wilson. 2009. MAGE-11 F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators. J. Biol. Chem. 284: 34793-34808.

Askew, E.B., S. Bai, A.J. Blackwelder, and E.M. Wilson. 2010. Transcriptional synergy between melanoma antigen protein-A11 (MAGE-11) and p300 in androgen receptor signaling. J. Biol. Chem. 285: 21824-21836.

Askew, E.B., J.T. Minges, A.T. Hnat, and E.M. Wilson. 2011. Structural features discriminate androgen receptor N/C terminal and coactivator interactions. Mol. Cell Endocrinol. PMID: 21664945.

Mellor, L., C.B. Knudson, D. Hida, E.B. Askew, and W. Knudson. 2013. Intracellular domain fragment of CD44 alters CD44 function in chondrocytes.  J. Biol. Chem. 288: 25838-25850. 

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