Randall H. Renegar, Ph.D.

Randall Renegar

Professor

office: Brody 7W-39B
phone: 252-744-2845
email: renegarra@ecu.edu

B.S., North Carolina State University
M.S., Michigan State University
Ph.D., University of Florida
Postdoctoral Fellow, University of Florida


Research

Previous efforts in our laboratory focused on relaxin, an endocrine hormone produced by the ovary and/or placenta, and its role in regulation of uterine smooth muscle function during pregnancy.More recently our laboratory has collaborated with Dr. Joseph Chalovich (Department of Biochemistry and Molecular Biology) to study of synaptopodin-2, a smooth muscle regulatory protein.Studies have focused on the role of synaptopodin-2 in actin and myosin filament assembly, disassembly and interaction.We also have an ongoing research relationship with Dr. Chris Geyer (Department of Anatomy and Cell Biology) proving support in the use of electron microscopy in his study of mammalian germ cell development.

I also serve as Director of the Brody School of Medicine's Electron Microscope Core. In this capacity I provide training to Brody faculty, staff and students in the preparation, sectioning and viewing of biological materials as well as assist investigators in completing the ultrastructural components of their projects on a fee-for-service basis. Core facility equipment available includes a JEOL 1200EX transmission electron microscope equipped with a Soft Imaging Systems MegaView III CCD camera, Leica EM UC6 ultramicrotome and Electron Microscopy Sciences plasma discharge unit.


Selected Publications

Renegar, R.A., J.M. Chalovich, B.D. Leinweber, J.T. Zary, and M.M. Schroeter. 2008. Localization of the actin-binding protein fesselin in chicken smooth muscle. Histochem. Cell Biol. 131: 191-196.

Zhang, G., L. Ding, R. Renegar, X.M. Wang, Q. Lu, S. Huo, and Y.-H. Chen. 2011. Hydroxycamptothecin-loaded Fe3O4 nanoparticles induce human lung cancer cell apoptosis through caspase-8 pathway activation and disrupt tight junctions. Cancer Sci. 102: 1216-22.

Ding, L., Z. Lu, O. Foreman, R. Tatum, Q. Lu, R. Renegar, J. Cao, and Y.H. Chen. 2012. Inflammation and disruption of the mucosal architecture in claudin-7 deficient mice. Gastroenterology 142: 305-15.

Niedenberger, B., V. Chappell, E. Kaye, R. Renegar, and C. Geyer. 2013.  Nuclear localization of the actin binding protein palladin in Sertoli cells. Mol. Reprod. Dev. 80: 403-413.


Former Students and Post-Doctoral Fellows

Name Title Location
Stephanie Barnes, M.S. Homemaker Birmingham, AL
Chet Johns, M.D., Ph.D. Family Physician Martin General Hospital, Williamston, NC
Margaret Maira, Ph.D, PT Physical Therapist University of New Mexico Hospital, Albuquerque, NM
R. Brian McCaslin, M.S. Patent Attorney Biotechnology and Pharmaceutical Practice Group, Foley & Lardner, Washington, DC
Melissa Roberts, M.S.    

List of Faculty