office: Brody 7W-41
B.S., Wayne State University
Ph.D., Wayne State University School of Medicine
Prostate cancer is the single most common form of non-skin cancer in men in the United States and is the focus of research in our laboratory. Because survival of the patient with prostatic carcinoma is related to the extent of tumor progression, our approach is to compare the behavior, and biochemical traits, of early-stage human prostate cancer cells to their counterparts from advanced and drug resistant stages of this disease. These studies have revealed that the progression to advanced prostate cancer is commonly associated with alterations in proteins that are intimately involved in signal transduction pathways.
We recently introduced the first discovered signaling molecule that, by itself, has the potential to advance the recurrence of human prostate cancer. The protein is called protein kinase C-epsilon and we are now working to understand precisely how this signaling molecule works within these cells using in vitro, ex vivo, and in vivo model systems. An incomplete list of the methods used in our experiments would include the use of transgene, antisense, genomic, proteomic, cytometric, and confocal methods of analysis.
Prekeris, R., M.W. Mayhew, B.J. Cooper, and D.M. Terrian. 1996. Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. J. Cell Biol. 132: 77-90.
Prekeris, R. and D.M. Terrian. 1997. Brain myosin V is a synaptic vesicle-associated motor protein: evidence for a Ca2+-dependent interaction with the synaptobrevin-synaptophysin complex. J. Cell Biol. 137: 1589-1601.
Prekeris, R., R.M. Hernandez, M.W. Mayhew, M.K. White, and D.M. Terrian. 1998. Molecular analysis of the interactions between protein kinase C-ε and filamentous actin. J. Biol. Chem. 273: 26790-26798.
Wu, D., T.L. Foreman, C.W. Gregory, M.A. McJilton, G.G. Wescott, O.H. Ford, R.F. Alvey, J.L. Mohler, and D.M. Terrian. 2002. Protein kinase C-epsilon has the potential to advance the recurrence of human prostate cancer. Cancer Res. 62: 2423-2429.
Wu, D. and D.M. Terrian. 2002. Regulation of caveolin-1 expression and secretion by a protein kinase C-epsilon signaling pathway in human prostate cancer cells. J. Biol. Chem. 277: 40449-40455.
Terrian, D.M. (Ed.). 2003. Cancer Cell Signaling: Methods and Protocols. Methods in Molecular Biology. Humana Press, Totowa, New Jersey. 218:1-333.
McJilton, M.A., C.V. Sikes, G.G. Wescott, D. Wu, T.L. Foreman, C.W. Gregory, D.A. Weidner, O.H. Ford, A.M. Lasater, J.L. Mohler, and D.M. Terrian. 2003. Protein kinase Cε interacts with Bax and promotes survival of human prostate cancer cells. Oncogene. 22:7958-7968.
Wu, D., C.U. Thakore, G.G. Wescott, J.A. McCubrey, and D.M. Terrian. 2004. Integrin signaling links protein kinase C-epsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells. Oncogene 23: 8659-8672.
Lehmann, B.D., J.A. McCubrey, M.S. Paine, W.H. Chappell, and D.M. Terrian. 2007. A dominant role for p53-dependent cellular senescence in radiosensitization of human prostate cancer cells. Cell Cycle 6: 595-605.
Thakore, C.T., B.D. Lehmann, J.A. McCubrey, and D.M. Terrian. 2007. Intracellular signaling in cancer. Cancer: From Mechanisms to Therapeutic Approaches (R.A. Meyers, ed.). Wiley-VCH Verlag GmbH, Weinheim. 155-190.
Lehmann, B.D., J.A. McCubrey, and D.M. Terrian. 2007. Radiosensitization of prostate cancer by priming the wild-type p53-dependent cellular senescence pathway. Cancer Biol. Ther. 6: 1165-1170.
Steelman, L.S., P.M. Navolanic, M.L. Sokolosky, J.R. Taylor, B.D. Lehmann, W.H. Chappell, S.L. Abrams, E.W.T. Wong, K.M. Stadelman, D.M. Terrian, N.R. Leslie, C.P Downes, A.M. Martelli, F. Stivala, M. Libra, R.A. Franklin, and J.A. McCubrey. 2008. Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibition. Oncogene 27: 4086-4095.
Lehmann, B.D., M.S. Paine, A.M. Brooks, W.H. Chappell, J.A. McCubrey, and D.M. Terrian. 2008. Distinct roles for p107 and p130 in Rb-independent cellular senescence. Cell Cycle 7: 1262-1268.
Lehmann, B.D., M.S. Paine, A.M. Brooks, J.A. McCubrey, R.H. Renegar, and D.M. Terrian. 2008. Senescence-associated exosome release from human prostate cancer cells. Cancer Res. 68: 7864-7871.
Zeng, Y., A. Abdallah, J.P. Lu, T. Wang, Y.-H. Chen, D.M. Terrian, K. Kim, and Q. Lu. 2009. δ-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles. Mol. Cancer 8:19.
Chappell, W.H., B.D. Lehmann, D.M. Terrian, S.L. Abrams, L.S. Steelman, and J.A. McCubrey. 2012. p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3. Cell Cycle 11: 4579-4588.
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