Selected Publications
Song A., Labella S., Korneeva N.L., Keiper B.D., Aamodt E.J., Zetka M. and Rhoads R.E. (2010) A C.elegans eIF4E-family member upregulates translational at elevated temperatures of mRNAs encoding MSH-5 and other meiotic crossover proteins. J. Cell Sci. 123(Pt 13): 2228-2237. (link)
Henderson, M.A., Cronland, E., Dunkelbarger, S., Contreras, V., Strome, S., and Keiper, B.D. (2009) A germ line-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm. J. Cell Sci. 122: 1529-1539. (link)
Contreras, V., Richardson, M.A., Hao, E. and Keiper, B.D. (2008). Depletion of the cap-associated isoform of translation factor eIF4G induces germline apoptosis in C. elegans. Cell Death Differ. 15: 1232-1242. (link)
Dinkova, T.D., Keiper, B.D., Korneeva, N.L., Aamodt, E.J. and Rhoads, R.E. (2005) Translation of a small subset of Caenorhabditis elegans mRNAs is dependent on a specific eukaryotic translation initiation factor 4E isoform. Mol. Cell. Biol. 25(1): 100-113.
Miyoshi, H., Dwyer, D., Keiper, B.D., Jankowska, M., Darzynkiewicz, E. and R.E. Rhoads (2002) Discrimination between mono- and trimethylated cap structures by two isoforms of Caenorhabditis elegans eIF4E. EMBO J. 21(17): 4680-4690.
Amiri, A., Keiper, B.D., Kawasaki, I., Fan, Y., Kohara, Y., Rhoads, R.E., and S. Strome (2001) An Isoform of eIF4E is a Component of Germ Granules and is Required for Spermatogenesis in C. elegans. Development 128 (20): 3899-3912.
Keiper, B.D., Lamphear, B.J., Deshpande, A.M., Jankowska-Anyszka, M., Aamodt, E.J., Blumenthal, T., and R.E. Rhoads (2000) Functional Characterization of Five eIF4E Isoforms in Caenorhabditis elegans. J. Biol. Chem. 275 (14): 10590-10596. (link)
Keiper, B.D.and R.E. Rhoads (1999b) Translational Recruitment of Xenopus Maternal mRNAs in Response to Poly(A) Elongation Requires Initiation Factor eIF4G-1. Dev. Biol. 206 (1): 1-14.
Keiper, B.D.and R.E. Rhoads (1997) Cap-Independent Translation Initiation in Xenopus Oocytes, Nucleic Acids Res. 25 (2): 395-403.
Spevak, W., Keiper, B.D., Stratowa, C., and M.J. Castanon (1993) Saccharomyces cerevisiae cdc15 Mutants Arrested at a Late Stage in Anaphase are Rescued by Xenopus cDNAs Encoding N-ras or a Protein with ß-Transducin Repeats (ßTrCP). Mol. Cell. Biol. 13 (8), 4953-4966.
Invited Reviews
Keiper, B.D(2003) Translation of mRNAs in Xenopus Oocytes. In: Encyclopedia of Life Sciences. (Online Reviews) London: Nature Publishing Group. (http://www.els.net/)
Keiper, B.D., Gan, W., and R.E. Rhoads (1999a) Molecules in Focus: Protein Synthesis Initiation Factor 4G, Int. J. Biochem. Cell Biol. 31(1): 37-41. (link)
Recent Funding
National Science Foundation NSF MCB0842475 2009-2012
Title: “Translational control of growth & apoptosis in C. elegans development by
initiation factors”
National Science Foundation NSF MCB0321017 2004-2008
Title: “Function of Tissue-specific eIF4E Isoforms in Caenorhabditis elegans”
ECU Division of Research & Graduate Studies
Research Development Grant (ECU) 2008-2009
Title: “Translational control of growth and apoptosis in the C. elegans ovary”
Leo Jenkins Cancer Center (Dr. Mary A Farwell, co-PI)
Seed Grant (ECU) 2006
Title: “Targeted depletion of N-terminally extended eIF4G-1 isoforms in breast
cancer cell lines to reduce proliferation and/or increase susceptibility to
apoptosis”
North Carolina Biotechnology Center (Dr. Jim McCubrey, co-PI)
2004-IDG 1002, Institutional Development Grant 2005-2006
Title: “Phosphor-Imaging and Fluorescence-Imaging Core Facility at ECU
Brody School of Medicine”
(top)
