Timothy A. Jones, Ph.D
Professor
Jonesti@ecu.edu
Phone: 252-744-6088 Fax: 252-744-6109
Academic Degrees
B.S. University of California, Davis Biological Sciences
Ph.D. University of California, Davis Physiology
Academic Appointments
July 2004 to present-Professor, East Carolina University, College of Allied Health Sciences, Dept. of Communication Sciences and Disorders
Sept. 1998 to June 2004-Professor of Surgery and Physiology, University of Missouri, School of Medicine, Columbia , MO
Febr. 1994 to June 2004-Director of Research, Division of Otolaryngology, University of Missouri School of Medicine, Columbia, MO
Febr. 1994 to Aug. 1998-Associate Professor of Surgery and Physiology, University of Missouri School of Medicine, Columbia, MO
July 1995 to Sept. 1996-Visiting Professor, Section of Neurobiology, Physiology & Behavior, Division of Biological Sciences, University of California, Davis, CA
July 1988 to Jan. 1994-Associate Professor of Physiology, University of Nebraska Medical Center, College of Dentistry, Dept. of Oral Biology, Lincoln, NE
Oct. 1988 to Jan. 1994-Associate Professor, Courtesy Faculty Appointment, Dept. of Special Education and Communication Disorders, University of Nebraska, Lincoln, NE
June 1986 to Oct. 1988-Assistant Professor, Courtesy Faculty Appointment, Dept. of Special Education and Communication Disorders, University of Nebraska, Lincoln, NE
Aug. 1982 to June 1988-Assistant Professor of Physiology, University of Nebraska Medical Center, College of Dentistry, Dept. of Oral Biology, Lincoln, NE
July 1980 to Aug. 1982-NASA Research Associate (NASA NAGW-70), University of Louisville, Kentucky and University of California, Davis, CA
Research Interests
Vestibular and auditory function in the developing avian embryo and neonatal mammal, the embryonic cochlear tonotopic map, factors influencing embryonic development, comparative studies on vestibular and auditory systems and the pharmacology of the inner ear synapses.
I have broad interests in the evolution of sensory systems and in particular the role that gravity may have played in shaping gravity receptor systems across species. Ongoing research programs include the study of central and peripheral sensory processing in the vestibular and auditory systems. I investigate the ontogeny of function in these systems and factors that may alter or control development.
Ongoing Research Topics:
a. Vestibular and auditory function in the developing avian embryo and neonatal mammal.
b. The embryonic cochlear tonotopic map.
c . Factors influencing embryonic development, vestibular sensory deprivation.
d. Comparative studies on vestibular and auditory systems (lizards, birds and mammals).
Current Research Grants
Ontogeny of spatial coding in the mouse utricle (9/1/2003-2008)
Principal Investigator: NIH NIDCD R01 DC005776
Development & connections of the spiral ganglion (2002-2008)
Consultant: NIH NIDCD R01 DC 000160 (PI: Patricia Leake, UCSF)
Mathematical models of gravity receptor activity (Section Title). NSF Research Experiences for Undergraduates (REU) Site: Summer Research Projects in Biosystems Modeling and Analysis". (10/1/2003- 2006)
Co -Investigator, Section Director (PI: Satish S. Nair, MU)
Gravity receptors, gender and regulation of cardiovascular function (2002-2004)
Project Leader (Project 1D)
NASA Research Program Grant (RPG): Human Health From Earth to Space: A NASA- MU Partnership for Understanding Sex Differences in Physiology (PI: Meredith Hay)
Selected Refereed Publications
Jones, T.A., P. Leake, S. Russell, O. Stakhovskaya and B. Bonham. (2007) Spontaneous discharge patterns in cochlear ganglion cells prior to the onset of hearing in cats. Journal of Neurophysiology, 98:1898-1908.
Kim, Y.S., T.A. Jones, M. Chertoff, & W. Nunnally. (2006) Columella footplate motion and the cochlear microphonic potential in the embryo and hatchling chicken. Journal of the Acoustical Society of America, 120(6): 3811-3822.
Jones TA, Jones SM. (2006) Vestibular evoked potentials. In: Burkard RF, Don M, Eggermont JJ (Eds.) Auditory Evoked Potentials. Lippincott Williams & Wilkins: Baltimore, MD.
Hoffman L.F., M.D. Ross, J. Varelas, S. Jones, & T.A. Jones. (2006) Afferent Synapses are Present in Utricular Hair Cells from Otoconia-Deficient Mice. Hearing Research, 222: 35-42.
Jones SM, Jones TA, Johnson KR, Yu H, Erway LC, Zheng QY (2006) A comparison of vestibular and auditory phenotypes in inbred mouse strains. Brain Research, 1091:40-46.
Jones T.A., S.M. Jones and K.C. Paggett. (2006) The emergence of hearing in the chicken embryo. J. Neurophysiology, 96:128-141.
Jones, S.M., K.R. Johnson H. Yu, L.C. Erway, K.N. Alagramam, N. Pollak and T.A. Jones. (2005) A quantitative survey of gravity receptor function in mutant mouse strains. J. of the Association for Research in Otolaryngology, 6(4):297-310.
Xue B, Skala K, Jones TA, Hay M (2004) Diminished baroreflex control of heart rate responses in otoconia deficient C57BL/6JEi head tilt (het) mice. American Journal of Physiology: Heart and Circulatory Physiology, 287(2):H741-747.
Irons-Brown SR, Jones TA (2004) Effects of selected pharmacological agents on avian auditory and vestibular compound action potentials. Hearing Research. 195:54-66.
Fuller PM, Jones TA, Jones SM, Fuller CA (2004) Evidence for macular gravity receptor modulation of hypothalamic, limbic and autonomic nuclei. Neuroscience. 129: 461-471
Jones SM, Erway LC, Yu H, Johnson KR, Jones TA (2004) Gravity receptor function in mice with graded otoconial deficiencies. Hearing Research, 191, 34-40.
Irons-Brown SR, Jones SM, Jones TA (2003) The simultaneous in vivo perilymphatic perfusion of avian auditory and vestibular end organs. Journal of Neuroscience Methods, 131 (1-2), 57-64.
Zhang Z, Zhang X, Avniel W, Song Y, Jones SM, Jones TA, Fermin C, Chen Y (2003) Malleal processus brevis is dispensable for normal hearing in mice. Developmental Dynamics, 227, 69-77.
Jones SM, Subramanian G, Avniel W, Guo Y, Burkard RF, Jones TA (2002) Stimulus and recording variables and their effects on mammalian vestibular evoked potentials. Journal of Neuroscience Methods, 118, 23-31.
Fuller PM, Jones TA, Jones SM, Fuller CA (2002) Neurovestibular modulation of circadian and homeostatic regulation: A vestibulo-hypothalamic connection? Proceedings of the National Academy of Sciences. 99(24), 15723-15728.
Jones TA, Jones SM , & Paggett, K. (2001) Primordial rhythmic bursting in embryonic cochlear ganglion cells. Journal of Neuroscience, 21(20):8129-8135.
Jones SM, Jones TA, Bell PL, Taylor MJ (2001) Gravity receptor polarization vectors evidenced by linear vestibular evoked potentials. Hearing Research, 154: 54-61.
