||The focus of my research is the study of functional gap junction mediated cell-to-cell communication in cardiac tissue under normal and pathophysiologic conditions. One area of particular interest is the elucidation of the role of cell-to-cell communication on donor cell engraftment, trans-differentiation and function as applied to cell transplantation therapies.
This research includes both an in situ model of a heterogeneous cardiac myocyte/stem cell co-culture and in-vivo small animal heart model. Confocal fluorescence microscopy, a multisite fiber optic imaging system and micro-electrode array data acquisition system are used to image and provide high temporal and spatial measurements of intracellular ionic and transmembrane voltage changes and electrical signal propagation in cardiac tissue.
Barbara J. Muller-Borer, Ph.D.
The Brody School of Medicine
East Carolina Heart Institute at ECU
115 Heart Drive, Room #2247
Greenville, NC 27834