Alan P. Kypson, MD

Alan P. Kypson

ECU Physicians - Cardiothoracic Surgery
East Carolina Heart Institute at ECU
115 Heart Drive, Greenville, NC 27834

Phone: 252-744-4400
Fax: 252-744-2812

Specialties

  • Cardiothoracic Surgery

Board Certification

  • American Board of Surgery
  • American Board of Thoracic Surgery

Education

  • Medical School: Columbia University College of Physicians & Surgeons
  • Internship: Duke University Medical Center, 1994
  • Residency: Duke University Medical Center, 2002
  • Fellowship: Duke University Medical Center

Publications

Anderson, C. A., Rodriguez, E., Shammas, R. L. , & Kypson, A. P. (2009). 'Early constrictive epicarditis following coronary artery bypass surgery.'. Annals of Thoracic Surgery, 87 (2), 642-643.

Rodriguez, E., Kypson, A. P. , Anderson, C. A. , Ferguson, Jr., T. B. , Neufer, P. D. , & Anderson, E.J., (2009). 'Reduced fatty acid metabolism and elevated mitochondrial H2O2 emission are associated with decreased PPAR± in diabetic human myocardium.'. Journal of Surgical Research, 151 (2), 282.

Kypson, A. P., Blum, J. L. , Li, Y., Strader, J. T. , Lawson, J. H. , Niklason, L.E., & Dahl, S.L., (2009). 'Long term patency of decellularized tissue engineered vascular grafts in a canine model.'. Journal of Surgical Research, 151 (2), 223.

Anderson, C. A., Kypson, A. P. , & Chitwood, Jr., W. R. (2008). Robotic mitral surgery: current and future role. Current Opinion in Cardiology, 23 (2), 117-120.

Kypson, A. P., Anderson, C. A. , Rodriguez, E., & Koutlas, T. C. (2008). 'Double aortic arch in an adult undergoing coronary bypass surgery: a therapeutic dilemma?'. European Journal of Cardiothoracic Surgery, 34 (4), 920-921.

Anderson, C. A., Kypson, A. P. , Hudson, W., Ferguson, Jr., T. B. , & Rodriguez, E. (2008). SPY Imaging Assessment Correlates with Transesophageal Echocardiogram Assessment of Ventricular Function During OPCAB. Innovations, 3 (3), 155-157.

Anderson, E. J., Rodriguez, E., Kypson, A. P. , Lust, R. M. , & Neufer, P. D. (2008). 'Evidence of abnormal mitochondrial function in permeabilized fibers from diabetic human myocardium.'. Diabetes.

Tyson, G. H., Parker, F., Goettler, C., & Kypson, A. P. (2008). 'Novel therapeutic approaches to combined cardiac and aortic traumatic injuries.'. Journal of Trauma, 65 (6), 1534-1535.

Burrows, B. J., Collins, M., Muller-Borer, B., & Kypson, A. P. (2008). 'Cellular cardiomyoplasty: results of injected mesenchymal stem cell survival rates in a beating heart model'. Journal of Surgical Research, 144 (2), 274-5.

Muller-Borer, B., Gunst, P. R. , Collins, M. C. , Cascio, W. E. , & Kypson, A. P. (2007). Quantum dot labeling of mesenchymal stem cells. Journal of Nanobiotechnology, 5 (1), 9-17.

Kypson, A. P., Anderson, C. A. , Lochmuller, C. M. , Dixon, K., & Rodriguez, E. (2007). Squamous cell carcinoma of the pericardium found during coronary bypass surgery of possible cutaneous origin. Annals of Thoracic Surgery, 84 (5), 1735-1736.

Kypson, A. P., Blum, J. L. , Li, Y., Strader, J. T. , Williams, T. P. , Hensley, MT. Niklason, LE. Dahl, SH., (2007). Long term Patency of Decellularized Vascular Grafts in a Canine Model. Circulation, 116 (16:II), 444.

Hudson, W., Collins, M. C. , deFrietas, D., Sun, Y. S. , Muller-Borer, B., Kypson, AP., (2007). Beating and arrested intramyocardial injections are associated with significant mechanical loss: implications for cardiac cell transplantation. Journal of Surgical Research, 142 (2), 263-267.

Cook, R. C., Nifong, L. W. , Enterkin, J. E. , Charland, P. J. , Reade, C. C. , Kypson, AP. Masroor, S. Chitwood, Jr., WR., (2007). Significant reduction in annuloplasty time with the use of nitinol clips in robotically-assisted mitral valve repair. Journal of Thoracic Cardiovascular Surgery, 133 (5), 1264-1267.

Kypson, A. P., Tyson, G. H. , Collins, M., Sun, Y., Nifong, L. W. , Muller-Borer, B., (2007). Significant mechanical loss is associated with direct intramyocardial injection for cellular cardiomyoplasty. Journal of Surgical Research, 137 (2), 295.

Tyson, G. H., Rodriguez, E., Cinar-Elci, O., Koutlas, T. C. , Chitwood, W. R. , Ferguson, TB. Kypson, AP., (2007). Cardiac surgery in patients with body mass index exceeding 45: outcomes and long-term results. Annals of Thoracic Surgery, 84 (1), 3-9.

Rodriguez, E., Kypson, A. P. , Moten, S. S. , Nifong, L. W. , & Chitwood, W. R. (2006). Robotic mitral surgery at East Carolina University: A six year experience. International Journal of Medical Robotics and Computer Assisted Surgery, 2 (3), 211-215.

Muller-Borer, B. J., Gunst, P. R. , Collins, M. C. , Cascio, W. E. , & Kypson, A. P. (2006). 'Long-Term Labeling of Mesenchymal Stem Cells Using Quantum Dot Bioconjugates'. Circulation, 114 (18), II-662.

Kypson, A. P., Reade, C. C. , Wood, W., Mohr, F. W. , & Chitwood, W. R. (2006). Robotically assisted repair of a papillary muscle injury due to blunt trauma. Journal of Trauma, 61 (1), 209-210.

Kypson, A. P. (2006). Reply to the Editor: CO2 embolism induced by endoscopic saphenous vein harvesting during CABG. Journal of Thoracic Cardiovascular Surgery, 132 (6), 1502-1503.

Reade, C. C., Bower, C. E. , Schuler, C. M. , Austin, T. C. , Charland, P. J. , smith, NL. Sun, YS. Nifong, LW. Chitwood, Jr., WR. Kypson, AP., (2005). Acute effects of suction retraction on atrial hemodynamics and histology. Journal of Thoracic Cardiovascular Surgery, 130 (1), 114-119.

Kypson, A. (2005). Sudden cardiac arrest after coronary bypass grafting secondary to massive carbon dioxide embolism. Journal of Thoracic and Cardiovascular Surgery, 130, 936-7.

Reade, C. C., Johnson, J. O. , Bolotin, G., Freund, Jr., W. L. , Jenkins, N. L. , Bower, CE. Masroor, S. Kypson, AP. Nifong, LW. Chitwood, Jr., WR., (2005). Combining robotic mitral valve repair and microwave atrial fibrillation ablation: techniques and initial results. Annals of Thoracic Surgery, 79 (2), 480-484.

Kypson, A. P. & Chitwood, W. R. (2005). The use of robotics in cardiovascular surgery. Future Cardiology, 1 (1), 61-67.

Kypson, A. P., Frazier, D. W. , & Moran, J. F. (2005). Internal mammary artery injury following transvenous pacemaker implantation. Journal of Thoracic and Cardiovascular Surgery, 129 (3), 677-678.

Reade, C. C., Kypson, A. P. , & Williams, J. M. (2005). Valve sparing aortic root replacement after prior Starr-Edwards aortic valve replacement. Journal of Heart Valve Disease, 14 (5), 695-696.

Reade, C. C., Bower, C. E. , Bailey, B. M. , Maziarz, D. M. , & Masroor, S. (2005). Robotic mitral valve annuloplasty with double arm nitinol U-clips. Annals of Thoracic Surgery, 79 (4), 1372-1376.

Kypson, A. (2005). Re-examining contraindications for minimally invasive mitral valve surgery. Heart Surgery Forum, 79, 480-4.

Kypson, A. (2005). Valve sparing aortic root replacement after prior Starr-Edwards aortic vavle replacement. Journal of Heart Valve Disease, 14, 695-6.

Kypson, A. (2005). Acute effects of suction retraction on atrial hemodynamics and histology. Journal of Thoracic and Cardiovascular Surgery, 130, 114-9.

Kypson, A. P. & Chitwood, Jr., W. R. (2005). Palmar microcirculation following harvesting of the radial artery in coronary revascularization. Annals of Thoracic Surgery, 79 (3), 1030.

Kypson, A. P. & Chitwood, Jr., W. R. (2005). Early clinical results with a magnetic connector for distal coronary artery anastomoses. Annals of Thoracic Surgery, 79 (5), 1743.

Kypson, A. (2005). Robotic mitral valve annuloplasty with double arm Nitinol U-clips. Annals of Thoracic Surgery, 79, 1372-6.

Kypson, A. (2005). Combining robotic mitral valve repair and microwave atrial fibrillation ablation: techniques and initial results. Annals of Thoracic Surgery, 79, 480-4.

Bolotin, G., Kypson, A. P. , Reade, C. C. , Chu, V., Freund, W. L. , Nifong, WL. Chitwood, Jr., WR., (2004). Should a video-assisted mini-thoracotomy be the approach of choice for re-operative mitral valve surgery? Journal of Heart Valve Disease, 13, 155-158.

Bolotin, G., Scott, W. W. , Austin, T. C. , Charland, P. J. , Kypson, A. P. , Nifong, LW. Salleng, K. Chitwood, Jr., WR., (2004). Robotic skeletonizing of the internal thoracic artery: is it safe? Annals of Thoracic Surgery, 77 (4), 1262-1265.

Kypson, A. P. & Chitwood, W. R. (2004). Robotic applications in cardiac surgery. International Journal of Advanced Robotic Systems, 1 (2), 87-92.

Khan, N. U., Lerrick, K. S. , Kypson, A. P. , & Saha, P. K. (2004). Pitfalls of coronary angiography in aortic dissection. International Journal of Angiology (13), 84-85.

Kypson, A. P. & Chitwood, W. R. (2004). Robotically assisted cardiac surgery. Indian Heart Journal, 56 (6), 618-621.

Kypson, A. P. (2004). Perfusion for minimally invasive cardiac surgery. Heart Surgery Forum, 7 (4), E298-299.

Kypson, A. P., Nifong, L. W. , & Chitwood, W. R. (2004). Robot-assisted surgery: training and re-training surgeons. International Journal of Medical Robotics and Computer Assisted Surgery, 1 (1), 70-76.

Koutlas, T. C., Maziarz, D. M. , Conquest, A. M. , Williams, J. M. , Scott, W. W. , Kypson, AP. Chitwood, Jr., WR., (2004). Clinical results using the St. Jude medical 'symmetry' aortic connector system in 400 coronary artery bypass patients. Journal of American College of Cardiology, 43 (5), Supp. A:273A.

Kypson, A. (2004). Robotic applications in cardiac surgery. International Journal of Advanced Robotic Systems, 1, 87-92.

Kypson, A. (2004). Pitfalls of coronary angiography in aortic dissection. Internation Journal of Angiology, 13, 84-5.

Bolotin, G., Kypson, A. P. , Reade, C. C. , Chu, V., & Freund, W. L. (2004). Should a video-assisted mini-thoracotomy be the approach of choice for re-operative mitral valve surgery? Journal of Heart Valve Disease, 13, 155-158.

Reade, C. C., Bower, C. E. , Kypson, A. P. , Nifong, L. W. , Wooden, W. A. , Chitwood, Jr., WR., (2004). Re-examining contraindications for minimally invasive mitral valve surgery. Heart Surgery Forum, 8 (39), 39-41.

Reade, C. C., Bower, C. E. , Bailey, B. M. , Maziarz, D. M. , Kypson, A. P. , Nifong, LW. Chitwood, Jr., WR., (2004). Learning curves associated with robotic mitral valve repair. Heart Surgery Forum, 7 (4), E302.

Kypson, A. (2004). Robot-assisted surgery: training and re-training surgeons. International Journal of Robotics and Computer Assisted Surgery, 1, 70-6.

Kypson, A. (2004). Robotically-assisted left atrial fibrillation ablation and mitral valve repair through a right mini-thoracotomy. Annals of Thoracic Surgery, 78, e63-4.

Bolotin, G., Kypson, A. P. , Nifong, L. W. , & Chitwood, W. R. (2003). A technique for evaluating competitive flow for intra-operative decision making in coronary artery surgery. Annals of Thoracic Surgery, 76 (6), 2118-2120.

Kypson, A. P., Nifong, L. W. , & Chitwood, W. R. (2003). Robotic mitral valve surgery. Surgical Clinics of North America, 83 (6), 1387-1403.

Swaminathan, M., Kypson, A. P. , Perna, J. G. , Davis, R. D. , & Stafford-Smith, M. (2003). Right ventricular rupture during off pump coronary bypass surgery. Journal of Cardiothoracic and Vascular Anesthesiology, 17 (1), 87-89.

Kypson, A. P., Morphew, E., Jones, R., Gottfried, M. R. , & Siegler, H. F. (2003). Heterotopic ossification in rectal cancer: a rare finding with a novel proposed mechanism. Journal of Surgical Oncology, 82 (2), 132-136.

Kypson, A. P., Warner, J. J. , Telen, M. J. , & Milano, C. A. (2003). Paroxysmal cold hemoglobinuria and cardiopulmonary bypass: a case report. Annals of Thoracic Surgery, 75 (2), 579-581.

Kypson, A. P. (2003). Perfusion for robotic and minimally invasive cardiac surgery. Heart Surgery Forum, 6 (2), :111-112.

Bolotin, G., Kypson, A. P. , Nifong, L. W. , & Chitwood, Jr., W. R. (2003). Video-assisted mitral valve repair and left atrial ablation through a right mini-thoracotomy. Heart Surgery Forum, 6 (2), 105.

Kypson, A. (2003). Robotic skeletonizing of the internal thoracic artery: is it safe? Annals of Thoracic Surgery, 77, 1262-5.

Bolotin, G., Scott, W. W. , Austin, T. C. , Charland, P. J. , Kypson, A. P. , Reade, CC. Chitwood Jr., WR., (2003). Robotic skeletonizing of the mammary artery: is it safe? Heart Surgery Forum, 6 (1), :S39-40.

Kypson, A. (2003). Robotic mitral valve surgery. Surgical Clinics of North America, 83, 1387-403.

Kypson, A. (2003). Should a video-assisted mini-thoracotomy be the approach of choice for re-operative mitral valve surgery? The Journal of Heart Valve Disease, 13, 155-8.

Kypson, A. (2003). A technique for evaluating competitive flow for intra-operative decision making in coronary artery surgery. Annals of Thoracic Surgery, 76, 2118-20.

Bolotin, G., Kypson, A. P. , Nifong, L. W. , Reade, C., Freund, Jr., W., Chitwood, Jr., WR., (2003). Robotic-assisted mitral valve repair with microwave atrial fibrillation ablations: early clinical results. Journal of the American College of Surgeons, 197 (3), :S24.

Reade, C. C., Bower, C. E. , Schuler, C. M. , Austin, T. C. , Charland, P. J. , Kypson, AP. Nifong, LW. Chitwood, Jr., WR., (2003). Acute effects of suction retraction on atrial hemodynamics and histology. Journal of the American College of Surgeons, 197 (3), :S26.

Bolotin, G., Shapira, Y., Gotler, Y., Frolkis, I. V. , Kypson, A. P. , Nesher, N. Chitwood, Jr., WR. Uretzky, G., (2003). The potential advantage of 'no-touch' aortic technique in off-pump complete arterial revascularization. Heart Surgery Forum, 6 (1), :S51.

Kypson, A. P. & Glower, D. D. (2002). Port-access approach for combined aortic and mitral valve surgery. Annals of Thoracic Surgery, 73 (5), 1657-1658.

Kypson, A. P. & Glower, D. D. (2002). Minimally invasive tricuspid surgery using port-access. Annals of Thoracic Surgery, 74 (1), 43-45.

Kypson, A. P., Onaitis, M. W. , Feldman, J. M. , & Tyler, D. S. (2002). Carcinoid and chylous ascites: an unusual association. Journal of Gastrointestinal Surgery, 6 (5), 781-783.

Glower, D. D., Landolfo, K. P. , Kypson, A. P. , Bashore, T. M. , Harrison, K., Wang, A. Warner, JJ., (2002). Is port-access applicable to complex mitral valve repair? Heart Surgery Forum, 5 (1), 76-87.

Shah, A. S., White, D. C. , Emani, S., Kypson, A. P. , Lilly, R. E. , Wilson, K. Glower, DD. Lefkowitz, RJ. Koch, WJ., (2001). In vivo ventricular gene delivery of a b-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation, 103 (9), 1311-1313.

Shah, A. S., Lilly, R. E. , Kypson, A. P. , Tai, O., Hata, J. A. , Pippen, A. Silvestry, SC. Lefkowitz, RJ. Glower, DD. Koch, WJ., (2000). Intracoronary delivery and overexpression of the b2-adrenergic receptor in the heart: prospects for molecular VAD. Circulation, 101 (4), 408-414.

Shah, A. S., White, D. C. , Tai, O., Hata, J. A. , Wilson, K. H. , Pippen, A. Kypson, AP. Glower, DD. Lefkowitz, RJ. Koch, WJ., (2000). Adenovirus-mediated genetic manipulation of the myocardial b-adrenergic signaling system in transplanted hearts. Journal of Thoracic and Cardiovascular Surgery, 120 (3), 581-588.

Hughes, G. C., Kypson, A. P. , Annex, B. H. , Yin, B., St. Louis, J. D. , Biswas, SS. Coleman, E. DeGrado, TR. Donovan, CL. Landolfo, KP. Lowe, JE., (2000). Induction of angiogenesis after TMR: a comparison of holmium: YAG, CO2, and excimer lasers. Annals of Thoracic Surgery, 70 (2), 504-509.

Shah, A. S., Atkins, B. Z. , Hata, J. A. , Tai, O., Kypson, A. P. , Lily, RE. Davis, JW. Koch, WJ. Glower, DD., (2000). Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling. Journal of Thoracic and Cardiovascular Surgery, 120 (2), 342-349.

St. Louis, J. D., Hughes, G. C. , Kypson, A. P. , DeGrado, T. R. , Donovan, C. L. , Coleman, RE. Yin, B. Steenbergen, C. Landolfo, KP. Lowe, JE., (2000). An experimental model of chronic myocardial hibernation. Annals of Thoracic Surgery, 69 (5), 1351-1357.

Kypson, A. P., Wentzensen, N., Georgiade, G. S. , & Vaslef, S. N. (2000). Traumatic vertebrojugular arteriovenous fistula: a case report. Journal of Trauma, 49 (6), 1141-1143.

Kypson, A. P., Hendrickson, S. C. , Akhter, S. A. , Wilson, K., McDonald, P. H. , Lilly, RE. Dolber, PC. Glower, DD. Lefkowitz, RJ. Koch, WJ., (1999). Adenoviral-mediated gene transfer of the b2 -adrenergic receptor enhances cardiac function. Gene Therapy, 6 (7), 1298-1304.

Hughes, G. C., Baklanoc, D. V. , Annex, B. H. , Biswas, S. S. , Kypson, A. P. , Pippen, AM. Yin, B. Donovan, CL. Lowe, JE. Landolfo, KP., (1999). Denervation is not the long-term mechanism of action of transmyocardial laser revascularization. Circulation, 100 (18), I-249.

Shah, A. S., White, D. C. , Baklanov, D., Lilly, R. E. , Kypson, A. P. , Glower, DD. Koch, WJ., (1999). In vivo intracoronary delivery and overexpression of a bARK inhibitor to the failing heart: prospects for molecular ventricular assistance. Circulation, 100 (18), I-481.

Tai, O. S., Shah, A. S. , Kypson, A. P. , Glower, D. D. , & Koch, W. H. (1999). Brain death induces increased b-adrenergic receptor (bAR) kinase 1 expression in the heart. Circulation, 100 (18), I-165.

Hughes, G. C., Annex, B. H. , Yin, B., Pippen, A. M. , Lin, P., Kypson, AP. Peters, KG. Lowe, JE. Landolfo, KP., (1999). Transmyocardial laser revascularization (TMR) limits in vivo adenoviral-mediated gene transfer in porcine myocardium. Journal of American College of Cardiology, 33 (2), 355A.

Hughes, G. C., Kypson, A. P. , Yin, B., St. Louis, J. D. , Biswass, S. S. , Annex, BH. Coleman, RE. DeGrado, TR. Donovan, CL. Landolfo, KP. Lowe, JE., (1999). Induction of angiogenesis following transmyocardial laser revascularization in a model of chronic ischemia: a comparison of holmium: YAG, carbon dioxide, and excimer lasers. Surgical Forum, L, 115-117.

Hughes, G. C., Kypson, A. P. , St.Louis, J. D. , Annex, B. H. , Coleman, R. E. , DeGrado, TR. Donovan, CL. Lowe, JE. Landolfo, KP., (1999). Improved perfusion and contractile reserve after transmyocardial laser revascularization in a model of hibernating myocardium. Annals of Thoracic Surgery, 67 (6), 1714-1720.

Hughes, G. C., Annex, B. H. , Yin, B., Pippen, A. M. , Lin, P., Kypson, AP. Peters, KG. Lowe, JE. Landolfo, KP., (1999). Transmyocardial laser revascularization (TMR) limits in vivo adenoviral-mediated gene transfer in porcine myocardium. Cardiovascular Research, 44 (1), 81-90.

Shah, A. S., Lilly, R. E. , Kypson, A. P. , Tai, O., Hata, J. A. , Baklanov,D. Glower, DD. Koch, WJ., (1999). In vivo intracoronary delivery to and overexpression of the human b2-adrenergic receptor in the right ventricle: prospects for molecular right ventricular assistance. Surgical Forum, 119-120.

Maurice, J. P., Shah, A., Kypson, A. P. , Hata, J., White, D. C. , Glower, DD. Koch, WJ., (1999). Molecular b-adrenergic signaling abnormalities in failing rabbit hearts after infarction. American Journal of Physiology, 276 (6), H1853-1860.

Shah, A. S., Atkins, B. Z. , Hata, J. A. , Kypson, A. P. , Walton, G. B. , sudarshen, S. Davis, JW. Wolfe, WG. Glower, DD., (1998). Right ventricular overload depresses ventricular performance and alters global beta-adrenergic signaling. Circulation, 98 (17), 554-555.

Shah, A. S., Hata, J. A. , Kypson, A. P. , Glower, D. D. , & Koch, W. J. (1998). Adenoviral-mediated overexpression of the beta-adrenergic receptor kinase inhibitor in a cardiac transplant model. Surgical Forum, XLIX, 278-279.

St. Louis, J. D., Hendrickson, S. C. , Kypson, A. P. , Hughes, G. C. , Coleman, R. E. , Donovan, CL. Degrado, TR. Seabage, L. Abden-aleem, S. Landolfo, KP. Lowe, JE., (1998). An experimental model of myocardial hibernation. Journal of American College of Cardiology, 31 (2), 409A.

Kypson, A. P., Peppel, K., Akhter, S. A. , Lilly, R. E. , Glower, D. D. , Lefkowitz, RJ. Koch, WJ., (1998). Ex vivo adenoviral-mediated gene transfer in the transplanted adult rat heart. Journal of Thoracic and Cardiovascular Surgery, 115 (3), 623-630.

Hughes, G. C., Lowe, J. E. , Kypson, A. P. , St. Louis, J. D. , Pippen, A. M. , Peters, KG. Coleman, RE. DeGrado, TR. Donovan CL. Annex, BH. Landolfo, KP., (1998). Neovascularization after transmyocardial laser revascularization in a model of chronic ischemia. Annals of Thoracic Surgery, 66 (6), 2029-2036.

Channon, K. M., Kypson, A. P. , Daggett, C. W. , Blazing, M. A. , Koch, W. J. , George, SF., (1997). Enhanced pulmonary nitric oxide production and vasomotor function after in vivo pulmonary artery adenoviral gene transfer of nitric oxide synthase. European Heart Journal, 18 (3), 118.

Kypson, A. P., Akhter, S. A. , Peppel, K., Hendrickson, S. C. , McDonald, P., Lilly, RE. Glower, DD. Lefkowitz, RJ. Koch, WJ., (1997). Adenoviral-mediated gene transfer of the b2-adrenergic receptor improves function of the transplanted rat heart. Circulation, 96 (8), I-670.

Skaer, C. A., Akhter, S. A. , Kypson, A. P. , McDonald, P., Peppel, K. C. , Koch, WJ., (1997). Adenoviral-mediated b-adrenergic rescue of failing ventricular cardiomyocytes. Circulation, 96 (8), I-483.

Maurice, J. P., Kypson, A. P. , Skaer, C. A. , & Koch, W. J. (1997). b-adrenergic signaling characteristics in an infarct heart model. Circulation, 96 (8), I-362.

Kypson, A. P. (1997). Enhanced pulmonary nitric oxide production and vasomotor function after in vivo pulmonary artery adenoviral gene transfer of nitric oxide synthase. European Heart Journal, 18.

Kypson, A. P., El-Shewy, H. M. , Soloma, S. H. , Abd-Alla, O., Lowe, J. E. , Abdel-aleem, S., (1997). Effects of chronic inhibition of fatty acid oxidation on stress tolerance in the heart. Journal of Molecular and Cellular Cardiology, 29 (6), 92.

Channon, K. M., Kypson, A. P. , Blazing, M. A. , Daggett, C. W. , Koch, W. J. , George, SF., (1997). In vivo pulmonary artery adenoviral gene transfer of nitric oxide synthase enhances pulmonary nitric oxide production. Heart, 77 (I), P8.

Kypson, A. P., Daggett, C. W. , Channon, K. M. , Gullotto, C., George, S. E. , Koch, WJ., (1997). In vivo pulmonary adenoviral-mediated gene transfer of nitric oxide synthase increases nitric oxide production. Surgical Forum, XLVII (333-335).

Kypson, A. P., Akhter, S. A. , Skaer, C. A. , McDonald, P. H. , Peppel, K. C. , Glower, DD. Lefkowitz, RJ. Koch, WJ., (1997). Restoration of b-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proceedings National Academy of Science USA, 94, 12100-12105.

Sabiston, D. C., Kypson, A. P. , & Friesinger, G. C. (1997). Severe stenosis of the left main coronary artery with endarterectomy and graft: 33-year follow-up. Annals of Thoracic Surgery, 64 (5), 1159-1560.

Lilly, R. E., Peppel, K., Kypson, A. P. , Silvestry, S. C. , Glower, D. D. , Koch, WJ. Lefkowtiz, RJ., (1996). Intracoronary administration of adenovirus for gene transfer into adult rabbit myocardium. Surgical Forum, XLVII (279-281).

Kypson, A. P., Akhter, S. A. , Pippen, K., Lilly, R. E. , Dolber, P., Glower, DD. Lefkowitz, RJ. Koch, WJ., (1996). Global overexpression of b-adrenergic receptors in the myocardium via adenoviral-mediated gene transfer. Surgical Forum, XLVII, 282-284.

Trouve, R., Nahas, G., Manger, W., & Kypson, A. P. (1990). Anticatecholaminergic properties of cocaine antidotes. FASEB Journal, 4 (4).

Trouve, R., Nahas, G., & Kypson, A. P. (1989). Angiotensin II and cocaine lethal intoxication. FASEB Journal, 3 (3), Part I.

Nahas, G., Trouve, R., Manger, W., & Kypson, A. P. (1989). Cocaine, catecholamines and calcium homeostasis. The Physiologist (32), 172.

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