November 6, 2013
Dr. S. Raza Shaikh, ECDOI researcher from the Department of Biochemistry and Molecular Biology, has published a paper that appears on the cover of the November 2013 issue of the Journal of Lipid Research. The article is entitled: “N-3 PUFAs enhance the frequency of murine B cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity.” Heather Teague, PhD student in the same department, is the primary author.
"The n-3 polyunsaturated fatty acids docosahexaenoic and eicosapentaenoic acid enhance B cell function. N-3 PUFAs administered to mice for 10 weeks increased IgM production compared to a lean control diet. Mice consuming a high-fat diet exhibited decreased serum IgM. However, addition of n-3 PUFAs to the high-fat diet increased the frequency of select B cell subsets and rescued the decrement in IgM levels."