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Shaikh lab - website

(8/26/14)The Shaikh lab currently has three major projects . 1) The first project is trying to understand how omega-3 fatty acids, modeling pharmacological intake, serve to boost B cell mediated immunity in diet-induced obesity. Obese individuals display poor responses to vaccinations and infections and therefore there is a need to develop therapeutics....

Hickner lab - website

(8/13/14)The Hickner Lab investigates areas of obesity, aging, exercise, nutrition, microvascular blood flow and lipolysis in skeletal muscle and adipose tissue. The areas of study have been diverse, encompassing exercise training and nutritional interventions across the lifespan, from prepubescent children to aged individuals. The studies have focused primarily on the regulation....

jon with awards - website

Jon Busada Receives Awards
(8/07/14)Recently, Dr. Chris Geyer and Jonathan Busada attended the Society for the Study of Reproduction conference in Grand Rapids, Michigan. Jon received the Lalor Foundation Merit Award and was named 1 of 6 finalist to compete in the Trainee Platform Competition. Jon presented a talk entitled "Retinoic acid (RA) Regulates Kit translation in Prospermatogonia in the Neonatal Testis: A Novel Non-genomic Mechanism of RA-regulated Gene Expression" and won second place in the competition.

Zeczycki Lab - website

(8/05/14)The Zeczycki Lab’s focuses on determining the mechanisms of catalysis and unraveling the complexities of allosteric regulation of those multifunctional enzymes that are important to the pathogenesis of disease states. Understanding the activity and regulation of these enzymes is critical for the development of effective...

houmard lab - website

(7/30/14)The Houmard Lab’s primary focus is examining how skeletal muscle metabolism is altered with conditions such as obesity, type 2 diabetes and the aging process, and how a physically active lifestyle can counteract decrements associated with these conditions. Current ongoing projects involve how fat oxidation is altered with obesity, the role ...
mcclung lab - website
(7/25/14)The McClung Lab is focused on understanding the molecular mechanisms of angiogenesis and vascular remodeling in both physiologic and pathologic processes, including: exercise, peripheral artery disease (PAD), atherosclerosis, cardiac and cerebral ischemia, diabetes, and cancer. The lab is interested in how genetic variation may direct the integration of individual cellular responses to ischemic insult, resulting in differential manifestations of tissue pathology in both pre-clinical models and in clinical patient populations...

brown lab - website

(7/16/14)The DB Laboratory is interested in developing new therapies for heart disease. The heart is the most metabolically active organ in the body, and our experiments seek to determine how the mitochondrial network sustains the energy supply necessary to support cardiac electromechanical function. During many pathological states, such as diabetes or following a heart attack, mitochondria don’t “breathe” as well as they do in the healthy state. We want to know what goes wrong, and if there are interventions that can improve...

cabot lab - website

(7/9/14)The Cabot Lab focuses on sphingolipid metabolism as it relates to cancer growth and therapy. Sphingolipid metabolism is an area of cancer research that has risen to clinical prominence over the last 15 years. This is because ceramide, the aliphatic backbone of sphingolipids, acts as a powerful tumor suppressor, whereas its glycosylated product, glucosylceramide, catalyzed by the enzyme glucosylceramide...
geyer lab - website
(7/1/14)The Geyer lab is interested in how retinoic acid (RA) directs the initial steps of male germ cell development. RA regulates the sex-specific timing of meiotic initiation in mice, which in males occurs at postnatal day (P)10. However, RA signaling initiates 1 week prior, at P3-4, yet we know almost nothing about the pathways or mechanisms initiated by RA signaling...
bridges - website
(6/25/14)The Bridges Lab is specifically interested in how Vitamin A (retinol) oxidative metabolites alter immune cell adhesion. Although the requirement of vitamin A in immunity has long been appreciated, only within the past three decades have the molecular mechanisms by which retinoids elicit their effects been elucidated. We are currently using various molecular and cellular tools to investigate the impact of retinoids on...
(6/18/14) There are still two available dates left for the upcoming fall Metabolism Joint Lab Meetings. The new permanent location will be LSB202 and the available dates left are: Oct. 23rd & 30th. Please contact Drew Rockett or Ashley Busada if you would like to claim one of these dates. Once all the dates have been claimed we will be sending out the schedule for the meetings.
jon award - website
Jon Busada receives Lalor Foundation Award
(4/18/14) Jon Busada recently received a 2014 Lalor Foundation Merit Award. In addition, Jon will compete as a finalist in the Society for the Study of Reproduction (SSR) Trainee Research Award competition. As a part of the competition, he will present a platform presentation at the SSR 2014 meeting in Grand Rapids, MI on July 22. Jon is a PhD student in the Anatomy & Cell Biology Department.
Lei - website
Lei Wang receives Research and Creative Achievement Award
(4/4/14) ECU Research and Creative Achievement Week (RCAW) provides students with an excellent opportunity to practice their presentation skills and meet other creative scholars at ECU with similar interests. Lei Wang presented a poster in the Biomedical Sciences category at this years RCAW and was the winner of the graduate poster presentations. Lei and her mentor Dr. Bridges were invited to attend the RCAW Awards Luncheon on Friday April 4 where she accepted her award.
(2/14/14) Article by Kathryn Kennedy, ECU News Services: “A new space for collaborative medical research and robotics training was lauded by East Carolina University officials this week as a visionary project at the heart of the university’s mission and talents. The fourth floor of the East Carolina Heart Institute at ECU officially opened Feb. 13 as part of the regular two-day Board of Trustees meeting. Board members, faculty and other guests toured the 37,000-square-foot space...
(11/25/13) Dr. Skip Cummings and colleagues are to be congratulated for being awarded a second grant from the Bristol-Myers Squibb Foundation in the amount of $450,000. The team will develop and implement a program to address the management of diabetes, depression, and distress. East Carolina was invited to submit this second proposal after achieving successful outcomes with its first...
(11/6/13) Dr. S. Raza Shaikh's lab has published a paper that appears on the cover of November 2013 issue of the Journal of Lipid Research. The article is entitled: “N-3 PUFAs enhance the frequency of murine B cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity.” Heather Teague, PhD student in the Department of Biochemistry and Molecular Biology is the first author on the paper...
Office hall
(10/30/13) As the first moving date draws closer, I have put together some notes and details to help you prepare. Please make sure to read through them and contact Drew Rockett with any questions. This article will be updated periodically.
- All packing materials for Brody are located in 7W-44. Contact Drew Rockett to have them delivered to your lab, otherwise just come get them....
Office Construction
(9/25/13, updated 10/9/13) It is time to start getting excited about the new ECDOI home. On November 23-24 the first stage of the moving process will occur. Construction is nearing completion and planning has begun to get everything fully operational in our new space. During this process, all research equipment will be briefly out of operation at various times. Since much of this research equipment is also used by numerous other investigators around the university, I have compiled a detailed list ....
Construction 7-30-13
Construction Update
(7/31/13) Construction of the brand new East Carolina Diabetes and Obesity Institute (ECDOI) research facility on the 4th floor of the East Carolina Heart Institute (ECHI) is underway and ahead of schedule. Later this fall we will be moving into this world class research facility. We will continue to update you with details as they become available. We are very excited about all the possibilities such a facility will offer. Check back soon for more pictures.
Old ECDOI website
The East Carolina Diabetes and Obesity Institute (ECDOI) is getting a whole new look. Soon, we will be physically moving into a world class research facility, which is currently under construction. However, today we are here to show off our brand new digital headquarters. On this site you will find out all about what’s happening at the ECDOI. Look for featured news, research updates, current information on diabetes and obesity in the media, introductions to our faculty, staff, and students...

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