Research

Specific Aims

The Center for Health Disparities strives to develop an integrated, thematic research agenda focused on the genomic and physiological mediators (and impacts) of the social determinants of health disparities by integrating genetics, epigenetics, health behaviors, "big data" analytics, physical and social environments, and environmental exposures.


Directors

Doyle Cummings

Doyle Cummings, PharmD
Professor, Family Medicine

David Collier

David Collier, MD, PhD
Associate Professor, Pediatrics


Procedures Manual Cover Page

Standard Operating Procedures and Best Practices for Departmental Grant and Contract Administration (pdf)

A policy and procedures manual for grant and contract administration developed by Kevin Mills, Director of Grant and Contract Administration at East Carolina University's Center for Health Disparities.



Research Faculty

Core Faculty

Affiliated Faculty



A Few Recent Publications by Core Research Faculty

Reynolds K, Isom S, Bell R, Lawrence J, Imperatore G, Saydah S, Divers J, Hamman R, Mayer-Davis, E, Dabelea D.  Mortality in youth-onset Type 1 and Type 2 diabetes:  The SEARCH for Diabetes in Youth Study.  J Diabetes Complications 2018;32:545–549.

Jaiswal M, Divers J, Urbina EM, Dabelea D, Bell RA, Pettitt DJ, Imperatore G, Pihoker C, Dolan LM, Liese AD, Marcovina S, Linder B, Feldman EL, Pop-Busui R for the SEARCH for Diabetes in Youth Study Group. Cardiovascular autonomic neuropathy in adolescents and young adults with type 1 and type 2 diabetes:The SEARCH for Diabetes in Youth Cohort Study. Pediatric Diabetes. 2018 Jun;19(4):680-689. doi: 10.1111/pedi.12633. Epub 2018 Jan 2. PMID: 29292558. PMCID: PMC5938122 [Available on 2019-06-01].

Jilcott Pitts SB, Jahns L, Wu Q, Moran NE, Bell RA, Truesdale KP, Laska MN. A non-invasive assessment of skin carotenoid status through reflection spectroscopy is a feasible, reliable, and potentially valid measure of fruit and vegetable consumption in a diverse community sample. Public Health Nutrition2018 Feb 19:1-7. doi: 10.1017/S136898001700430X.

Luo H, Bell RA, Cummings DM, Chen Z. Diabetes preventive care practices in North Carolina, 2000–2015. Prev Chronic Dis 2018;15:170316. DOI: https://dio.org/10.5888/pcd15.170316.

Kearney GD, Bell RA.  Perceptions of global warming among the poorest counties in the Southeastern United States. J Public Health Manag Pract 2018 Mar 7. doi: 10.1097/PHH.0000000000000720.

Bell RA, Chen H, Saldana S, Bertoni AG, Effoe VS, Hairston KG, Kalyani RR, Norwood AF.  Comparison of measures of adiposity and cardiovascular disease risk factors among African American Adults:  The Jackson Heart Study. J Racial Ethn Health Disparities 2018;https://doi.org/10.1007/s40615-018-0469-7.

Luo H, Bell RA, Wright W, Wu Q, Wu B.  Trends in dental visits with and without self-reported diabetes and prediabetes, 2004 – 2014. JADA 2018;https://doi.org/10.1016/j.adaj.2018.01.008.

Luo H, Patil SP, Wu Q, Bell RA, Cummings DM, Adams AD, Hambidge B, Craven K, Gao F.  Validation of a combined health literacy and numeracy instrument for patients with type 2 diabetes. Patient Educ Couns. 2018 May 20. pii: S0738-3991(18)30260-X. doi: 10.1016/j.pec.2018.05.017

Luo H, Chen Z, Xu L, Bell RA.  Health care access and receipt of clinical diabetes preventive care for working-age adults with diabetes in states with and without Medicaid expansion:  Results from the 2013 and 2015 BRFSS.  J Public Health Manag Pract 2018 Jun 20. doi: 10.1097/PHH.0000000000000832.

Shakhnovich V, Smith PB, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL on behalf of the Best Pharmaceuticals for Children Act – Pediatric Trials Network. Obese children require lower doses of pantoprazole than non-obese peers to achieve equal systemic drug exposures. J Pediatr. 2018:193; 102-8.

Shakhnovich V, Smith BP, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL, Cohen-Wolkowiez M on behalf of the Best Pharmaceuticals for Children Act – Pediatric Trials Network. A population-based pharmacokinetic model approach to pantoprazole dosing for obese children and adolescents. Ped Drugs. 2018 https://doi.org/10.1007/s40272-018-0305-01

Kim S, White A, Scalzo F, Collier D. Elastic net ensemble classifier for event-related potential based automatic spelling.  Biomedical Signal Processing and Control. 2018 46; 166-173.  https://doi.org/10.1016/j.bspc.2018.06.005

Healy AM, Shubrook JH, Sadhu A, Schwartz FL, Cummings DM, Drake AJ, Tanenberg RJ: Endocrinologists’ Opinion of Diabetology as a Primary Care Subspecialty. Clinical Diabetes 2018 Feb; cd170097. https://doi.org/10.2337/cd17-0097

Luo H, Bell RA, Cummings DM, Chen Z: Diabetes preventive care practices in North Carolina: 2000-2015. Preventing Chronic Disease 2018;15:170316; DOI:https://doi.org/10.5888/pcd15.170316

Bushnell C, Duncan P, Lycan S, Condon C, Pastva A, Lutz B, Halladay J, Cummings DM, Arnan M, Jones S, Sissine M, Coleman S, Johnson A, Gesell S, Mettam L, Freburger J, Barton-Percival B, Taylor K, Bettger JP, Lundy-Lamm G, Rosamond W: A Patient-Centered Approach to Post-Acute Stroke Care: The COMprehensive Post-Acute Stroke Services (COMPASS) Model. J Am Geriatric Soc 2018;66:1025-1030

Halladay JR, Lenhart KC, Robasky K, Jones W, Homan W, Cummings DM, Cene CW, Hinderliter AL, Miller CM, Donahue KE, Garcia BA, Keyserling TC, Ammerman AS, Patterson C, DeWalt DA, Johnston LF, Willis MS, Schisler JC. Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations. Journal of Personalized Medicine 2018, 8(2), 16; https://doi.org/10.3390/jpm8020016 .

Duncan PW, Abbott RM, Rushing S, Johnson AM, Condon CN, Lycan SL, Lutz BJ, Cummings DM, Pastva AM, D’Agostino Jr RB, Stafford JM, Amoroso RM, Jones SB, Psioda MA, Gesell SB, Rosamond WD, Prvu-Bettger J, Sissine ME, Boynton MD, Bushnell CD. COMPASS-CP: An Electronic Application to Capture Patient-Reported Outcomes to Develop Actionable Stroke and Transient Ischemic Attack Care Plans. Circulation Cardiovasc Quality & Outcomes. 2018;11:e004444.

Mishriky BM, Tanenberg RJ, Sewell KA, Cummings DM: Comparing SGLT2 Inhibitors to DPP-4 Inhibitors as an add-on therapy to Metformin in Patients with Type 2 Diabetes: A systematic review and meta-analysis. Diabetes and Metabolism2018;44:112-120

Wu JR, Cummings DM, Halladay J, Donahue KE, Cene C, Hinderliter A, Bosworth HB, Miller C, Garcia B, Tillman J, DeWalt D: The effect of a practice-based multi-component intervention that includes health coaching on medication adherence and blood pressure control in rural primary care. J Clin Hypertension 2018; DOI: 10.1111/jch.13265; pg. 1-8.

Lutes LD, Cummings DM, Littlewood K, Solar C, Carraway M, Kirian K, Patil S, Adams A, Ciszewski S, Hambidge B: COMRADE: A Randomized Trial of an Individually Tailored Integrated Care Intervention for Uncontrolled Type 2 Diabetes with Depression and/or Distress in the Rural Southeastern U.S. Contemporary Clinical Trials 2018;70:8-14

Mishriky BM, Cummings DM, Powell JR, Sewell KA, Tanenberg RJ: Comparing once-weekly semaglutide to incretin-based therapies in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes and Metabolism 2018; https://doi.org/10.1016/j.diabet.2018.09.002

Mishriky BM, Tanenberg RJ, Cummings DM, Pories WJ: Re-examining Insulin Compared to Non-Insulin Therapies for Type 2 Diabetes: When in the Disease Trajectory is Insulin Preferable? Postgraduate Medicine 2018; ahead of print: DOI: 10.1080/00325481.2018.1533381

Luo H, Bell RA, Garg S, Cummings DM, Patil SP, Jones K: Trends and Racial/Ethnic Disparities in Diabetic Retinopathy among Adults with Diagnosed Diabetes in North Carolina: 2000-2015. NC Med Journal (accepted; in press)

Luo H, Patil S, Wu Q, Bell RA, Cummings DM, Adams AD, Hambidge B, Craven K, Gao F: Validation of a combined health literacy and numeracy instrument for patients with Type 2 diabetes. Patient Education and Counseling. 2018 Oct;101(10):1846-1851. doi: 10.1016/j.pec.2018.05.017. Epub 2018 May 20. PMID: 29805071

Cummings DM, Adams A, Halladay J, Hinderliter A, Donahue KE, Cene CW, Li Q, Miller C, Garcia B, Tillman J, Little E, DeWalt D: Race-Specific Patterns of Treatment Intensification among Hypertensive Patients using Home Blood Pressure Monitoring: Analysis Using Defined Daily Doses in the Heart Healthy Lenoir Study Annals of Pharmacotherapy 2018 Oct 3:1060028018806001. doi: 10.1177/1060028018806001. PMID:30282468

Arthur A, Terman A, Kurzontkowski C, Keene K, Babatunde T, Summers K. Molecular Evolution of Genes Associated with Preeclampsia: Genetic Conflict, Antagonistic Coevolution and Signals of Selection. Journal of Evolutionary Medicine. 2018

Green IE, Rahman SA, Owens DL, Sale MM, Currie LJ, Keene KL, Worrall BB, Southerland AM. Cervical Artery Dissection in Patients of African Ancestry. Cerebrovasc Dis. 2018 Dec 5;46(5-6):218-222. doi: 10.1159/000494704. PMID: 30517918

Davis Armstrong NM, Chen WM, Brewer MS, Williams SR, Sale MM, Worrall BB, Keene KL. Epigenome-Wide Analyses Identify Two Novel Associations with Recurrent Stroke in the Vitamin Intervention for Stroke Prevention Clinical Trial. Front Genet. 2018 Sep 6;9:358. doi: 10.3389/fgene.2018.00358. eCollection 2018. PMID: 30237808; PMCID: PMC6135883.

Callis-Duehl K, Keene KL, Christensen T, Stiller J. From DNA to Proteins: Learning tertiary folding through problem solving. The Science Teacher (TST). 2018 August;86(1):35-39.

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Bis JC, Pastinen T, Ruusalepp A, Schadt EE, Koplev S, Björkegren JLM, Codoni V, Civelek M, Smith NL, Trégouët DA, Christophersen IE, Roselli C, Lubitz SA, Ellinor PT, Tai ES, Kooner JS, Kato N, He J, van der Harst P, Elliott P, Chambers JC, Takeuchi F, Johnson AD, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M, Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, Hoed MD, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Amin N, Aparicio HS, Arnett DK, Attia J, Beiser AS, Berr C, Buring JE, Bustamante M, Caso V, Cheng YC, Choi SH, Chowhan A, Cullell N, Dartigues JF, Delavaran H, Delgado P, Dörr M, Engström G, Ford I, Gurpreet WS, Hamsten A, Heitsch L, Hozawa A, Ibanez L, Ilinca A, Ingelsson M, Iwasaki M, Jackson RD, Jood K, Jousilahti P, Kaffashian S, Kalra L, Kamouchi M, Kitazono T, Kjartansson O, Kloss M, Koudstaal PJ, Krupinski J, Labovitz DL, Laurie CC, Levi CR, Li L, Lind L, Lindgren CM, Lioutas V, Liu YM, Lopez OL, Makoto H, Martinez-Majander N, Matsuda K, Minegishi N, Montaner J, Morris AP, Muiño E, Müller-Nurasyid M, Norrving B, Ogishima S, Parati EA, Peddareddygari LR, Pedersen NL, Pera J, Perola M, Pezzini A, Pileggi S, Rabionet R, Riba-Llena I, Ribasés M, Romero JR, Roquer J, Rudd AG, Sarin AP, Sarju R, Sarnowski C, Sasaki M, Satizabal CL, Satoh M, Sattar N, Sawada N, Sibolt G, Sigurdsson Á, Smith A, Sobue K, Soriano-Tárraga C, Stanne T, Stine OC, Stott DJ, Strauch K, Takai T, Tanaka H, Tanno K, Teumer A, Tomppo L, Torres-Aguila NP, Touze E, Tsugane S, Uitterlinden AG, Valdimarsson EM, van der Lee SJ, Völzke H, Wakai K, Weir D, Williams SR, Wolfe CDA, Wong Q, Xu H, Yamaji T, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worrall BB, Kittner SJ, Seshadri S, Fornage M, Markus HS, Howson JMM, Kamatani Y, Debette S, Dichgans M; AFGen Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; INVENT Consortium; STARNET; BioBank Japan Cooperative Hospital Group; COMPASS Consortium; EPIC-CVD Consortium; EPIC-InterAct Consortium; International Stroke Genetics Consortium (ISGC); METASTROKE Consortium; Neurology Working Group of the CHARGE Consortium; NINDS Stroke Genetics Network (SiGN); UK Young Lacunar DNA Study; MEGASTROKE Consortium; MEGASTROKE Consortium:.. Multi-ancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3. Epub 2018 Mar 12. PMID: 29531354; PMCID: PMC5968830.



A Few Current Research Grants of Core Faculty