Hisham Barakat, PhD

Division of Endocrinology, Department of Internal Medicine
The Brody School of Medicine
East Carolina University, Greenville, NC 27834
252.744.9845 (Office, Brody 3S-10)
barakath@ecu.edu

The focus of the research efforts in the lab of Hisham Barakat is on three related areas: Obesity, Diabetes and Cardiovascular Disease. Specifically, the work in the lab addresses questions related to alterations in lipid and lipoprotein metabolism in these metabolic disorders. Of particular interest is the determination of the underlying causes of the enhanced obesity that occurs in minority populations. Studies of lipid deposition, lipid mobilization and lipid oxidation have been on going for the past eight years and the results from these studies have been recognized as important contributions to the field. Below are some of our publications from 2002-2005.

1. Bower, J. F., Y. Deshaies, M. Pfeifer, R. J. Tanenberg, and H. A. Barakat. Ethnic differences in postprandial triglyceride response to a fatty meal and lipoprotein lipase in lean and obese African American and Caucasian women. Metabolism, 51: 211-217, 2002.

2. Tanner, C .J., H.A. Barakat, G. L. Dohm, W. Pories, K. MacDonald, P. Cunningham, M. Swanson, and J. A. Houmard. Muscle fiber type is associated with obesity and weight loss. Am J Physiol. 282: E1191-E1196, 2002.

3. Privette, J. D., J. Bradfield, and H.A. Barakat. Fatty acid oxidation by muscle homogenates of ob/ob mice. Am J Physiol. In Review, 2002.

4. Barakat, H., R Hickner, J. Privette, J. Bower, E. Hao, V. Udupi, A. Green, W. Pories, K. MacDonald. Differences in lipolytic function of adipose tissue preparations of African American and Caucasian women. Metabolism. 51:1514-1518, 2002

5. Bower, J. F. S. Vadlamudi, and H. A. Barakat. Ethnic differences in glyceride synthesis in subcutaneous and Omental fat depots. Am J. Physiol. 283: E988-E993, 2002

6. Privette, J. D., K. MacDonald, W. Pories and H. A. Barakat. Fatty acid oxidation by skeletal muscle homogenates from obese Black and White American women . Metabolism 52: 735-738, 2003

7. MacLean, P. S. J.F. Bower, S. Vadlamudi, J. Osborne, J. Bradfield, H. Burden, W. Bensch, R. Kauffman, and H. A. Barakat. Expression of human cholesteroyl ester transfer protein (CETP) prevents the formation of diet-induced atherosclerotic lesions in the proximal aorta of db/db mice. Areterio Thromb Vascul Disease. 23:1412-1415, 2003

8. M. Hulver, O. Saleh, K. MacDonald, W. Pories, and H. A. Barakat. Ethnic differences in adiponectin levels. Metabolism 53: 1-3, 2004

9. McConnaughey, M., K. A. Sheets, J. Davis, J. Privette, R. Hickner, B. Christian, and H. A. Barakat. Differences in Beta adrenergic receptor densities in omental and subcutaneous adipose tissue from obese Black American and Caucasian women. Metabolism 53: 247-251, 2004.

10. Davis J. M.D., R. C. Hickner, R. J.Tanenberg and H. A. Barakat. PYY Levels After a Fat Load in Black and White Women. Obesity Research, 2005. In Press

11. Vice E., J. D. Privette, R. C. Hickner, and H. A. Barakat. Ketone body metabolism in lean and obese women. Metabolism. 54:1542-5, 2005

12. MacLean, P., S. Vadalmudi, K. MacDonald, W. J. Pories, and H. A. Barakat. Suppression of hepatic CETP expression in obese humans with the development of type 2 diabetes mellitus. J Clin.Endocrinol. Metabolism. 90:2250-2258, 2005.

13. Galvin, V. B., H. A. Barakat, G. Kemeny, K. MacDonald, W. J. Pories, R. C. Hickner. eNOS content in adipose tissue from obese and lean African American and Caucasian Amercian women. Metabolism 54:1368-1373, 2005.

14. Scantlebury-Manning, T., J. Bower, K. Cianflone, and H. A. Barakat. Racial Difference in ASP and Leptin Correlate to Triglyceride in Lean and Obese African American and Caucasian Women. Int. J. Obesity, 2005.

15. Bower, J. F., J. M. Davis, E. Hao, H. A. Barakat. Differences in the transport of fatty acids and the expression of fatty acid transporting proteins in adipose tissue of obese Black and White women. Amer. J. Physiol. 290:E87-91, 2006.