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Shaw M. Akula

Shaw M. Akula

Associate Professor

B.V.Sc., Veterinary College and Research Institute, India
M.V.Sc., Madras Veterinary College, India
Ph.D., South Dakota State University

Phone: 252-744-2702
Fax: 252-744-3104
Email: akulas@ecu.edu


Research

Kaposi'ssarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8), a memberof the γ2-herpesvirus family, is involved in the pathogenesis of Kaposi'ssarcoma (KS), primary effusion lymphoma and a subset of multicentric Castlemandisease. KSHV was first described in KS lesion by representational differenceanalysis. KSHV associated diseases occur in HIV negative as well as HIVpositive patients around the world. KS is often times referred to asAIDS-defining illness. Advances in virus biology (includes both herpesvirusesand others) have been made by the use of virus specific target cells andanalyzing different stages of the virus infectious process, critical signalingcascades induced by the virus, and those cellular signals that benefit thevirus infection. However, there is very little research performed on the effectof such cellular signals on virus entry, infection, and pathogenesis. My labsprimary focus is on,

  1. Understanding the manner by which cellular proteins alter KSHV infection and mediated pathogenesis.
  2. Understanding the manner by which cellular signaling alter the milieu in HIV infected patients critical to AIDS-associated     pathogenesis. This part of the study is being pursued in collaboration with Paul Cook, MD (Chief, Division of Infectious Diseases; http://www.ecu.edu/cs-dhs/im/infectiousdiseases/index.cfm). We use human participants to understanding the role of cellular markers in dictating the outcome of infection with HIV and other AIDS-associated pathogens.

The long term goalswill be aimed at (1) understanding certain unexplained facets of the virusbiology specifically pertaining to virus entry and replication; and (2)developing anti-viral/anti-cancer therapies based on targeting specificsignaling molecule(s).


Publications

Popular works

A GUIDE to PhD Success. Akula SM. 2012.
http://www.amazon.com/Guide-PhD-Success-Shaw-Akula/dp/1622123484

Beyond the Future. AkulaSM. 2014
https://www.amazon.com/Beyond-Future-Shaw-M-Akula/dp/0990664805/ref=sr_1_2?ie=UTF8&qid=1472572063&sr=8-2&keywords=shaw+akula

Scientific peer-reviewed works

P.P. Cook, A.T. Stang, L.R. Walker, S.M. Akula, F.J. Cook, Bone mineral density and vitamin D levels in HIV African-American subjects receiving Tenofovir, Emtricitabine, Efavirenz versus Raltegravir, Darunavir, Ritonavir. South Med J (2016; In Press).

Hussein, A.M.H., Walker, L.R. and Akula, S.M. 2016. KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain. BMC Cancer 16:148-165.

Walker, L.R., Hussein, A.M.H., and Akula, S.M. 2015. Subcellular fractionation method to study endosomal trafficking of Kaposi's sarcoma-associated herpesvirus. Cell Biosci 6:1-10.

Walker, L.R., Hussein, A.M.H., and Akula, S.M. 2014. Disintegrin-like domain of glycoprotein B regulates Kaposi's sarcoma-associated herpesvirus infection of cells. J Gen Virol 95:1770-82.

Grange, P., Gressier, L., Williams, J.F., Dyson, O.F., Akula, S.M., and Dupin, N. 2012. Cloning a human saliva-derived peptide for preventing KSHV transmission. Journal of Investigative Dermatology 132(6):1733-5.

Dyson, O.F., Walker, L.R., Whitehouse, A., Cook, P.P., and Akula S.M. 2012. Resveratrol Inhibits KSHV Reactivation by Lowering the Levels of Cellular EGR-1. PLoS One 7(3):e33364.

Dyson, O.F., Traylen, C., and Akula, S. M. 2010. Cell membrane bound KSHV encoded gB promotes virus latency by regulating expression of cellular Egr-1. J. Biol. Chem. 285(48):37491-37502.

Dyson, O.F., Ford, P.W., Chen, D., Li, Y-Q., and Akula, S.M. 2009. Raman tweezers provide the fingerprint of cells supporting the late stages of KSHV reactivation. J. Cell. Mol. Med. 13:1920-1932.

Whitman, A.G., Dyson, O.F., Lambert, P.J., Oxendine, T.L., Ford, P.W., and Akula, S.M. 2007. Changes occurring on the cell surface during KSHV reactivation. J. Electron Microsc. 56:27-36.

Ford, P.W., Bryan, A.B., Dyson, O.F., Weidner, D.A., Chintalgattu, V., and Akula, S.M. 2006. RAF/MEK/ERK signalling triggers reactivation of Kaposi's sarcoma-associated herpesvirus latency. J. Gen. Virol. 87:1139-1144.

Bryan, B.A., Dyson, O.F., and Akula, S.M. 2006.Identifying Cellular Genes Crucial for the Reactivation of Kaposi's Sarcoma-Associated Herpesvirus Latency. J. Gen. Virol. 87:519-529.

Akula, S.M., Ford, P.W., Whitman, A.G., Hamden, K.E., Bryan, B.A., Cook, P.P., and McCubrey, J.A. 2005. Raf Induces Expression of Vascular Endothelial Growth Factor in Kaposi's Sarcoma-Associated Herpesvirus Infected Human B cells. Blood 105(11): 4516-4522.

Hamden, K.H., Ford, P.W., Whitman, A.G., Dyson, O.F., Cheng, S.Y., McCubrey, J.A., and Akula, S.M. 2004.Raf induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8) Infection. J. Virol 78(23):13381-13390.

Akula, S.M.,Ford, P.W., Whitman, A.G., Hamden, K.H., Shelton, J.G., and McCubrey, J.A.2004.Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection. Oncogene 23(30):5227-5241.

Akula, S.M., Pramod, N.P., Sharma-Walia, N, Wang, F-Z., Fegley, B., and Chandran, B.2003.Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8) Infection of Human Fibroblast Cells Occurs Through Endocytosis. J. Virol. 77(14):7978-7990.

Akula, S.M., Pramod, N.P., Wang, F-Z., and Chandran, B.2002.Integrin alpha3beta1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells. Cell 108(3):407-419.

View entire list of publications

http://www.ncbi.nlm.nih.gov/pubmed?term=Akula%20sm


Staff

Name Title Location Phone
Hussein, Hosni Doctoral Student Brody 5N99 / 136 252-744-2727 or 252-744-2725
Psyk, StevenGrad StudentBrody 5N99 / 136252-744-2727 or 252-744-2725
Okafor, IkennaStudentBrody 5N99 / 136252-744-2727 or 252-744-2725
Williams, John Research Specialist Brody 5N-99 / 136 252-744-2727 or 252-744-2725