Past Graduates

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The Brody School of Medicine
Department of Microbiology and Immunology
Health Sciences Campus

1989

BARRY R. STRIPP, Ph.D.

"Cloning, Sequencing and Expression of Newcastle Disease Virus Glycoprotein Genes"
Defended: September 25, 1989. (Dr. Henry 0. Stone, Jr., Advisor)

WILLIAM H. WALLACE, Ph.D.
"Genetic and Biochemical Analysis of Gluconate Utilization in Pseudomonas aeruginosa PAO1"
Defended: May 23, 1989. (Dr. Paul V. Phibbs, Advisor)

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1990

SCOTT D. COBOURN, Ph.D.
"The Biological Effects of Palindromic and Direct Repeat DNA Sequences with the Potential for Formation of DNA Secondary Structures"
Defended: March 30, 1990. (Dr. Uwe R. Muller, Advisor)

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1991

DALE L. LUDWIG, Ph.D.
"Influence of Copy Number and Chromosomal Position Effect on Heterologous Gene Expression in the Yeast Saccharomyces cerevisiae"
Defended: July 16, 1991. (Dr. Carlo V. Bruschi, Advisor)

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1992

PAUL A. ALGATE, Ph.D.
"Molecular Basis of the Abrogation of IL3 Dependency in Lymphoid Cell Lines Transformed by an Autocrine Mechanism"
Defended: November 24, 1992. (Dr. James A. McCubrey, Advisor)

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1993

MARK B. ROGERS, Ph.D.
"Molecular Genetic Analysis of Endogenous β-Lactamase Production in Bacteroides fragilis"
Defended: December 14, 1993. (Dr. C. Jeffrey Smith, Advisor)

MARTY W. MAYO, Ph.D.
"The Mechanism by Which Phorbol Esters Support the Proliferation of an Interleukin 3-Dependent Hematopoietic Cell Line"
Defended: December 2, 1993. (Dr. James A. McCubrey, Advisor)

PAUL W. TEBBEY, Ph.D.
"Identification of Arachidonic Acid as a Pluripotent Regulator of Gene Expression"
Defended: November 19, 1993. (Dr. Thomas M. Buttke, Advisor)

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1994

SHIWANI K. ARORA, Ph.D.
"Characterization of the crc Gene and its Product Required for Catabolite Repression Control in Pseudomonas aeruginosa"
Defended: November 28, 1994. (Dr. Paul V. Phibbs, Advisor)

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1995

BETSAIDA TORRES, Ph.D.
"Identification and Characterization of Thyroid Hormone Regulated Genes in Human Fibroblasts by mRNA Differential Display Analysis and Quantitative Competitive Polymerase Chain Reaction: Insights into Thyroid Hormone Receptor Isoform Specific Gene Regulation"
Defended: October 3, 1995. (Dr. Stephen Usala, Advisor)

LYNDON C. KIRBY, Ph.D.
"Chemical Synthesis and Characterization of Reverse Amide Analogs of Conjugated Bile Acids"
Defended: July 5, 1995. (Dr. James P. Coleman, Advisor)

LORITA M. REBELLATO, Ph.D.
"Specificity and Effectiveness of Polyclonal and Monoclonal Antibodies in the Induction of Primate Transplantation Tolerance"
Defended: April 6, 1995. (Dr. Judith M. Thomas, Advisor)

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1996

JAMES E. DeVENTE, Ph.D.
"Altered Protein Kinase C (PKC) Expression in the Human MCF-7 Breast Cancer Cell Line: Role of PKC Pathway in Breast Cancer Progression"
Defended: August 6, 1996. (Dr. Kirk Ways and Dr. James A. McCubrey Co-Advisors)

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1997

FIONA C. BEAUMONT, Ph.D.
"The Bordetella Alcaligin Siderophore System: A Study of Biosynthesis and Regulatory Genes"
Defended: November 20, 1997. (Dr. Sandra K. Armstrong, Advisor)

HO YOUNG KANG, Ph.D.
"Identification and Characterization of the Bordetella pertussis Alcaligin Siderophore Biosynthesis Operon"
Defended: October 8, 1997. (Dr. Sandra K. Armstrong, Advisor)

XIAO-YANG WANG, Ph.D.
"Autocrine Transformation of IL-3 Dependent Hematopoietic Cells Mediated by Intracisternal Type A Particle Transposition into the 3' Untranslated Region of IL-Gene"
Defended: January 28, 1997. (Dr. James A. McCubrey, Advisor)

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1998

WILLIAM D. PROCTOR, Ph.D.
"Genetic and Biochemical Characterization of HexR, a Negative Regulator of Carbohydrate Utilization of the hex Region of Pseudomonas aeruginosa PA01"
Defended: November 24, 1998. (Dr. Paul V. Phibbs, Advisor)

KIM M. KOSLOWSKI, Ph.D.
"The Characterization of Two Distinct Properties of the UL28 Protein in Pseudorabies Virus and Herpes Simplex Virus Type 1"
Defended: November 10, 1998. (Dr. Nels Pederson, Advisor)

PAUL E. HOYLE, Ph.D.
"Signaling through the Raf Family of Serine/Threonine Kinases in Hematopoietic Cells"
Defended: November 9, 1998. (Dr. James A. McCubrey, Advisor)

PAULA Y. ARNOLD, Ph.D.
"Antigen Presentation by T Cells: Evidence for T Cell Receptor-Mediated Uptake of Vesiculated Peptide/MHC Class II Complexes Derived from Antigen Presenting Cells"
Defended: July 14, 1998. (Dr. Mark D. Mannie, Advisor)

GENA D. TRIBBLE, Ph.D.
"Development of a Model of Transposition for the Bacteroides Mobilizable Transposon Tn4555"
Defended: April 20, 1998. (Dr. C. Jeffrey Smith, Advisor)

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1999

KARLA J. POSEKANY, Ph.D.
"Evaluation of α1,3 Galactosyltransferase for Cancer Gene Therapy: Anti-Gal Antibodies Exert In Vitro and In Vivo Anti-Tumor Activity"
Defended: February 16, 1999. (Dr. Kathryn M. Verbanac, Advisor)

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2000

CHRISTOPHER D. HERREN, Ph.D.
"Identification and Characterization of Genes Induced During Oxidative Stress in the Opportunistic Pathogen Bacteroides fragilis"
Defended: November 28, 2000. (Dr. C.Jeffrey Smith, Advisor)

CAROLINE R. WEINSTEIN-OPPENHEIMER, Ph.D.
"Roles of the RAS-RAF-ERK Signaling Pathway in the Development of Resistance to the Chemotherapeutic Drug Doxorubicin in the MCF-7 Breast Cancer Cell Line"
Defended: September 28, 2000. (Dr. James A. McCubrey, Advisor)

DARREN J. SMALLEY, Ph.D.
"Identification of Oxidative Stress Response Genes from the Obligate Anaerobe Bacteroides fragilis: Characterization of a Ribonucleoside Diphosphate Reductase that is Functional During Aerobic Conditions"
Defended: May 11, 2000. (Dr. C. Jeffrey Smith, Advisor)

WILLIAM L. BLALOCK, III, Ph.D.
"Autocrine Transformation of Hematopoietic Cells by the RAS/RAF/MAPK Pathway Member MEK1 and the Ability of BCL2 Overexpression to Enhance MEK-1 Mediated Transformation"
Defended: June 13, 2000. (Dr. James A. McCubrey, Advisor)

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2001

DHAVAL M. PATEL, Ph.D.
"Intercellular Exchange of Functional Class II MHC Glycoproteins Among Leukocytes is Activation-Dependent in the T Cell Compartment but is Activation-Independent in Other Types Of APC"
Defended: November 26, 2001. (Dr. M. Mannie, Advisor)

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2002

MINDI R. WALKER, Ph.D.
"T Cell Expression of MHC Class II Glycoproteins: Presentation of the Self Peptide Rat Myelin Basic Protein Induces Tolerance in the Lewis Rat Model of EAE"
Defended: April 1, 2002. (Dr. M. Mannie, Advisor)

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2004

JOHN G. SHELTON, Ph.D.
"A Conditionally Active v-ErbB Transforms Hematopoietic Cells To Cytokine-Independence and Promotes Cell Survival and Proliferation"
Defended: November 29, 2004 (Dr. James McCubrey, Advisor)

JOHN T. LEE, Ph.D.
"PI3K/AKT and RAF/MEK/ERK Signaling in Advanced Prostate Cancer: Implications for Resistance to Chemotherapeutic Compounds"
Defended: November 19, 2004 (Dr. James McCubrey, Advisor)

CHRISTIAN J. SUND, Ph.D.
"Identification of oxyR Independent Oxidative Stress Response Genes in the Obligate Anaerobe Bacteroides fragilis"
Defended: November 18, 2004 (Dr. C. Jeffrey Smith, Advisor)

CHRISTOPHER J. HOWE, Ph.D.
"A Novel Mechanism for the Activation of the CaM-Kinases by Hydrogen Peroxide and Their Role in the Phosphorylation of I-κB in Human T Lymphocytes"
Defended: April 16, 2004 (Dr. R. Franklin, Advisor)

JILL A. MAXWELL, Ph.D.
"The Mechanism and Kinetics of Reovirus T1- And T3-Induced Apoptosis of Human Colon and Pancreatic Cancer Cells"
Defended: March 29, 2004 (Dr. S. Oberhaus, Advisor)

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2005

CHERYL SPENCE, Ph.D.
"Characterization and Regulation of an Oxygen-Upregulated Starch Utilization Operon in the Obligate Anaerobe Bacteroides fragilis"
Defended: November 16, 2005 (Dr. C. Jeffrey Smith, Advisor)

OSWALDO G. RODRIGUEZ-MORA, Ph.D.
"Calcium/Calmodulin-dependent Kinases Participate in the Cell Cycle Regulation and Antiapoptotic Mechanisms in MCF-7 Human Breast Cancer Cells"
Defended: May 17, 2005 (Dr. Richard Franklin, Advisor)

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2006

BRIAN E. BULLMAN, Ph.D.
"Identification and Characterization Of PqsH, a Putative Monooxygenase Required for PQS Production, and Comparison To PqsL, an Opposing Putative Monooxygenase"
Defended:  April 5, 2006 (Dr. Everett C. Pesci, Advisor)

ERIC S. ANDERSON, Ph.D.
"Identification of the AraC-Like Transcriptional Regulator DhbR and Its Role in the Regulation Of The Genes Required For Siderophore Biosynthesis in Brucella abortus"
Defended:  November 21, 2006 (Dr. Roy M. Roop, II, Advisor)

MICHAEL L. HORNBACK, Ph.D.
"The Brucella abortus xthA-1 and xthA-2 Gene Products Play Overlapping Roles in Base Excision Repair and Resistance To Reactive Oxygen Intermediates"
Defended:  November 27, 2006 (Dr. Roy M. Roop, II, Advisor)

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2007


JAMES T. PAULLEY, Ph.D.
"Production Of BhuA By Brucella Abortus Is Required For Hemin Utilization And Virulence And Is Dependent On The Transcriptional Regulators RirA AndChrA" Defended: September 12, 2007  (Dr. R. Martin Roop, II, Advisor)

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2008


HEIDI DALRYMPLE, Ph.D.
"Exploring pathways of Lung Homeostasis:  Role of Alveolar Macrophages and Lymphocytes"
Defended:  July 23, 2008 (Dr. Mary Jane Thomassen, Advisor)

LINDSAY PEED, Ph.D.
"Mobilization of a Bacteriodes Conjugative Transposon, CTn341"
Defended:  September 2, 2008 (Dr. C. Jeffrey Smith, Advisor)

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2009

JARRETT T. WHELAN, Ph.D.
"Enforced Expression of HoxA9 in B-Lineage ALL Promotes Survival and Proliferation of Leukemic Cells"
Defended:  July 2, 2009 (Dr. Ted Bertrand, Advisor)

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2010

PAMELA R. COOK, Ph.D.
"Molecular Characterization Of The Activation Domain Of The HTLV-1 HBZ Protein And Its Interaction With The Kix Domain Of The Cellular Transcriptional Coactivators p300 And CBP"
Defended:  November 10, 2010 (Dr. Isabelle M. Lemasson, Advisor)


J. LORI BLANCHFIELD, Ph.D.
"Antigen- specific Tolerogenic Vaccines Inhibit Autoimmune Disease In A Rodent Model of Multiple Sclerosis"
Defended:  June 24, 2010 (Dr. Mark Mannie, Advisor)


KENDRA H. STEELE, Ph.D.
"The Brucella Abortus Alkyl Hydroperoxide Reductase Complex (AhpCD) is the Primary Scavenger of Endogenous Hydrogen Peroxide, and the ahpCD Operon is Regulated in Response to Endogenous Hydrogen Peroxide"
Defended:   April 12, 2010 (Dr. R. Martin Roop II, Advisor)

KRISTINA E. REHM, Ph.D.
"The Poxvirus A35 Protein Promotes Virulence by Regulating the Host Adaptive Immune Response"
Defended:  April 6, 2010 (Dr. Rachel L. Roper, Advisor)

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2011

MICHAEL A. REOTT, JR., Ph.D.
"Investigations into the Roles of Bacteroides Fragilis Thioredoxins During the Oxidative Stress Response"
Defended:  January 11, 2011 (Dr. C. Jeffrey Smith, Advisor)

OSSIE F. DYSON, Ph.D.
"REGULATION OF KSHV REPLICATION by GLYCOPROTEIN B:  Chronicles of a Virus and its Host"
Defended:  November 17, 2011 (Dr. Shaw M. Akula, Advisor)

WILLIAM H. CHAPPELL, Ph.D.
"p53 and NGAL: Dual Regulatory Roles in Advanced Prostate Cancer"
Defended:  Novemver 18, 2011 (Dr. James McCubrey, Advisor)


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2012

JENIFER F. OJEDA, Ph.D.
"The bhuTUV and bhuO gene products play vital roles in the ability of Brucella abortus to use heme as an iron source and are regulated in an iron-responsive manner by RirA and Irr"
Defended:  April 4, 2012 (Dr. R. Martin Roop II, Advisor)

 



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Brody School of Medicine
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