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2160 Herbert Court
Greenville, NC 27834

Phone:   744-1466
Fax:      744-2016
E-mail:   deventeja@ecu.edu

Faculty Rank:  Assistant Professor, Resident Research Director

Primary Specialty:  Obstetrics and Gynecology

Secondary Specialty:  Cell signaling

Interests/Skills:  Gestational Diabetes, Polycystic Ovary Syndrome, Obesity, Minimally Invasive Gynecologic Surgery, endometrial cancer cell signaling, insulin signaling.

Year Started at ECU:  2005

Residency/Internship:  Brody School of Medicine at East Carolina University, Greenville, NC (1991-2005)

Medical School:  Brody School of Medicine at East Carolina University, Greenville, NC (1997-2001)

College:  BS, North Carolina State University (1984-1989); MS, East Carolina University (1990-1992); PhD, Brody School of Medicine at East Carolina University (1992-1996)

deVente JE, Posekany K, Hooker J, Garris T, Qin W, Parker P, Fletcher D, Cook P, and Ways DK. Phorbol ester treatment of U937 cells overexpressing PKC-zeta induces cell death rather than differentiation.  American Association for Cancer Research Meetings, Abstract #452 (oral presentation) 1994.

deVente JE, Kukoly CA, Lozano G, and Ways DK.  Altered PKC expression in MCF-7 cells is associated with decreased levels of p53:  role in TPA induced apoptosis.  American Association for Cancer Research Meetings, Abstract #2600 (poster), 1995.

deVente JE, Kukoly C, Garris T, Bryant W, Yee D, Ways DK.  Transcriptional induction of insulin-like growth factor -1 (IGF-1) in human U937 leukemic cancer cells with altered protein kinase C (PKC) isoform expression.  American Association for Cancer Research Meetings, Abstract #1493 (poster) 1996.

deVente JE, Kukoly C, Garris T, Bryant W, Ways DK.  Down-regulation of IRS-1 expression by protein kinase C (PKC) in MCF-7 breast cancer cells. American Diabetes Assoc. Meetings, Abstract #568 (poster) 1996.

deVente JE, Kukoly C, Garris T, Bryant W, Yee D, Ways DK.  Transcriptional induction of insulin-like growth factor -1 (IGF-1) in human MCF-7 breast cancer cells with altered protein kinase C (PKC) isoform expression.  Endocrinology Society Meetings, Abstract #OR12-4 (oral presentation) 1996.

deVente JE, Thyfault J, Hedberg E, Anchan R, Thorne O, Isler C, and Dohm GL.  Gestational Diabetes is associated with depressed adiponectin levels. Society for Gynecologic Investigation, Abstract #905 (poster) 2004.

Zheng  D, Thyfault J, Bennett J, Isler C, Dohm GL, deVente JE.  Serine phosphorylation is increased in skeletal muscle from gestational diabetes mellitus patients.  FASEB Meeting, Abstract #2958 (poster) 2004.

Anchan R, Thyfault J,Shackelford P, Isler C, Newton E, Dohm GL, deVente JE. Marked decrease in neuropeptide-Y (NP-Y) concentrations 24 hours after delivery in gestational diabetics and control subjects. Society for Gynecologic Investigation, Abstract #695 (poster) 2005.

Rebellato L, Hewan-Lowe K, Briley K, Herrel J, deVente JE.  Elevated serum tumor necrosis factor-alpha in renal allograft rejection.  Amer. Society for Histocompatibility and Immunogenetics, Abstract #950251 (poster) 2005.

Zheng D, Dohm GL, Thyfault J, deVente JE.  TNF-alpha increased IRS-1 Ser 312 phosphorylation is associated with decreased insulin sensitivity in cultured human myotubes.  Keystone Symposia (Adipogenesis, Obesity, and Inflammation), Abstract #343 (poster) 2006.

Clark BM, Johnson JV, deVente JE.  High single-dose methotrexate treatment for ectopic pregnancy is not associated with a higher repeat dosing rate.  Society for Gynecologic Investigation, Abstract #625 (poster) 2006.

deVente JE, Shaver P.  Role of protein kinase C in the regulation of estrogen receptor expression and cell morphology in HEC-1B Human endometrial cancer cells. Society for Gynecologic Investigation, Abstract # 160 (poster) 2007

Friedman JE, deVente JE, Peterson RG, and Dohm GL.  Altered expression of muscle glucose transporter Glut-4 in diabetic fatty Zucker rats (ZDF/Drt-fa).  Am. J. Physiol.,1991; 261(6): E782-E788.

 

McCubrey JA, Smith SR, Algate PA, deVente JE, White MK, Steelman LS.  Retroviral infection can abrogate the factor-dependency of hematopoietic cells by autocrine and non-autocrine mechanisms depending on the presence of a functional viral oncogene.  Oncogene, 1993; 8:2905-2915.

 

White MK, deVente JE, Robbins PJ, Canupp DM, Mayo MW, Steelman LS, McCubrey JA.  Differential regulation of glucose transporter expression in hematopoetic cells by oncogenic transformation and cytokine stimulation.  Oncology Reports; 1994; 1: 17-26.

 

Ways DK, Posekany K, deVente J, Garris T, Chen J, Hooker J, Qin W, Cook P, Fletcher D, Parker P.  Overexpression of protein kinase C-  stimulates leukemic cell differentiation.Cell Growth and Diff  1994; 5:1195-1203.

Neufer PD, de Vente JE, Tapscott EB, Dohm GL.  Hindlimb perfusion induces Glut-1 and immediate early gene expression in skeletal muscle.  Am. J. Physiol. 1995;  286 (31): E866-E872.

 

Ways DK, Kukoly CA, deVente JE, Hooker JE, Bryant WO, Posekany K, Fletcher D, Cook P, Parker P. J.  MCF-7 breast cancer cells transfected with protein kinase C alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J. Clin. Invest. 1995;  95: 1906-1915.

 

deVente JE, Kiley S, Fletcher D, Garris T, Hooker J, Posekany K, Parker P, Cook P, Ways DK. Phorbol ester treatment of U937 cells with altered protein kinase C content and distribution induces cell death rather than differentiation. Cell Growth and Diff. 1995; 6: 371-382

 

deVente JE, Kukoly C, Bryant W, Posekany K, Chen J, Fletcher D, Parker P, Guillermina L, Cook P, Ways DK.  Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms:  Role for p53 independent induction of gadd45 in initiating death. J. Clin. Invest. 1995; 96: 1874-1886.

 

deVente JE, Bryant W, Posekany K, Chen J, Cook P, Ways DK.  Phorbol ester stimulated Cip-1 expression in p53-negative leukemic cells:  Death in the absence of a G1 arrest or differentiation. Oncology Reports. 1996; 3: 213-217.

 

McGowan K, de Vente J, Carey J, Ways DK, Pekala PH.  Protein kinase C isoform expression during the differentiation of 3T3-L1 preadipocytes:  Loss of PKC- isoform correlates with loss of PMA activation of NF-B and acquistion of the adipocyte phenotype. J. Cell Phys.  1996; 167: 113-120.

 

Carey JO, Posekany K, de Vente J, Pettit G, Ways DK.  Phorbol ester stimulated phosphorylation of PU.1:  Possible role in leukemic cell differentiation.  Blood.  1996; 87: 4316-4324.

 

deVente JE, Kukoly C, Garris T, Bryant W, Ways DK.  Transcriptional regulation of IRS-1 expression by protein kinase C.  J.Biol. Chem.  1996; 271: 32276-32280.

 

Torrance CJ, deVente JE, Jones JP, and Dohm GL.  Effects of thyroid hormone on GLUT4 glucose transporter gene expression and NIDDM in Rats.  Endocrinology.  1997; 138: 1204-1214.

 

deVente JE.  “For the good of the sick” and “for the cure of my patients.”  Current Surgery.  1999; 56: 82-83.

 

Thyfault JP, Hedberg EM, Anchan RM, Thorne OP, Isler CM, Newton ER, Dohm GL, and deVente JE.  Gestational diabetes is associated with depressed adiponectin levels.  Society of Gynecologic Investigation.  2005; 12(1):  41-45.