Study Doctor (Principal Investigator): Rosa E. Cuenca MD
Co-investigators: Gordon H. Downie MD, PhD, Ron A. Allison MD, and Claudio Sibata PhD.

This research study is designed to assess the ability of fluorescence imaging of the chest wall to provide data, which will be possibly used to produce a more sensitive method to diagnose the extent of disease, and improve the treatment of breast cancer with chest wall recurrence, for future patients. Imaging will be done both before and after photosensitizer injection and before and after light activation.

Data from a quality of life questionnaire, which will be completed by you a total of four times during this study, before treatment, at one, three and six months after treatment, will also give possible valuable information to future patients.

Plan and procedures
Researchers anticipate enrolling approximately 10 patients in this research study. The research team conducting this study at the Leo W. Jenkins cancer center consists of Dr. Cuenca, (surgical oncologist), Dr. Downie, (medicine doctor), Dr. Allison (radiation oncologist)) and Dr. Claudio Sibata, (PhD).

Before, and after photosensitizer injection and before and after light activation, a doctor will take a picture (florescence imaging), with a special camera, and then will do the regular biopsies of the tumor as per the patient's Photodynamic Therapy Treatment. Researchers will then compare the imaging with the biopsy data. The results of this comparison will not be used for the research subject's treatment, but will possibly be used for treatment of future patients.

A small part from the tissue that will be used for the subject's regular, standard of care biopsy will be taken to the lab for further experimental procedures.

Before the subject's light treatment, after two months of your treatment, after four months and after six months, the subject will be asked to fill out a "quality of life" questionnaire.

Potential risks and discomforts
The risk involved in the imaging process is minimal. No physical or psychological risks or discomforts are expected from either the imaging or the questionnaire. The research subject's treatment will not be modified or altered according to information gathered during the research study. Potential related risks to subject or embryo: No risks are expected.

Potential benefits
There mayor may not be any medical benefit to the research subject from participating in this study. Information gained from this study may help other people who have cancer.