Research Programs

Pediatric Cardiology

Pediatric Heart Network Research Studies Currently Enrolling:

Title of Research Study: Marfan Study
Principal Investigator: Charlie J. Sang, Jr., M.D.
Funded By: NIH/NHLBI

Device Studies Currently Enrolling:

Title of Research Study: ASD Closure Study
Principal Investigator: Charlie J. Sang, Jr., M.D.
Funded By: AGA Medical, Inc.

Other Studies Currently Enrolling:

Title of Research Study: Study drug vs placebo in neonates and infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary artery shunt (e.g. Blalock Taussig shunt)
Principal Investigator: Charlie J. Sang, Jr., M.D.
Funded By: Bristol Myers Squibb and Sanofi Aventis

Pediatric Endocrinology

Title of Research Study: Safety and Efficacy of study drug as mono-therapy and adjunctive therapy to oral anti-diabetic agents in adolescents with Type 2 Diabetes
Principal Investigator: Glenn D. Harris, M.D.
Funded By: Eli Lilly and Company

If you have any questions regarding these research studies, you may contact the Study Coordinator, Lori Jo Sutton, CCRC at 252-744-2161 (Phone) or 252-561-9545 (Pager).

Pediatric Oncology

Principle Investigators: Dr. George Hucks

Children’s Oncology Group Research Studies Currently Enrolling:

  • AALL05B1 A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
  • AALL08B1 Classification of Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)
  • AALL0932 Treatment of Patients with Newly Diagnosed Standard Risk B-Lymphoblastic Leukemia (B-ALL) or Localized B-lineage Lymphoblastic Lymphoma (B-LLy)
  • AALL1131 A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum
  • AAML08B1 Biology Study of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS)
  • ACCL0933 A Randomized Open-Label Trial of Caspofungin versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML)
  • ACCRN07 Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research Network (CCRN)
  • AHEP0731 Treatment of Children with All Stages of Hepatoblastoma with Temsirolimus (IND#122782, NSC#683864) Added to High Risk Stratum Treatment
  • AHOD04B1 Hodgkin Disease Banking Study
  • ALTE05N1 Umbrella Long-term Follow-up Protocol
  • ALTE11C1 Longitudinal Assessment of Ovarian Reserve in Adolescents with Lymphoma
  • ANBL00B1 Neuroblastoma Classification Biology Studies
  • AREN03B2 Renal Tumors Classification, Biology, and Banking Study
  • D9902 A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol
  • AALL1231 A Phase III Randomized Trial Investigating Bortezomib (NSC# 681239; IND# 58443) on a Modified Augmented BFM (ABFM) Backbone in Newly Diagnosed T- Lymphoblastic Leukemia (T-ALL) and T- Lymphoblastic Lymphoma (T-LLy)
  • ARST1321 Pazopanib Neoadjuvant Trial In Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754, IND# 118613)

If you have any questions regarding Children’s Oncology Group (COG) research studies, you may contact the Study Coordinator, Mary Lynn Sanderson, BS at 252-744-5404 (Phone) or 252-282-0095 (Pager).

Helpful Link(s): www.childrensoncologygroup.org

Pediatric Hematology

Title of Research Study: A Phase III randomized clinical trial to compare standard therapy (erythrocyte transfusions) with alternative therapy (hydroxyurea) for the maintenance of lowered TCD velocities in pediatric subjects with sickle cell anemia and abnormal pre-treatment TCD velocities (TWITCH)
Principal Investigator: Dr. Beng Fuh
Funded By: NIH
Title of Research Study: Evaluation of Purified Poloxamer 188 in children in crisis (EPIE): A phase 3 randomized, double-blind, placebo-controlled, multicenter clinical trial of ANX-188 (Purified Poloxamer 188) injection in children with sickle cell disease experiencing vaso-occlusive crisis
Principal Investigator: Dr. Beng Fuh
Funded By: Mast Therapeutics, Inc.
Title of Research Study: An Open-label, Multicenter Study of the Safety, Pharmacokinetics, and Efficacy of Buprenorphine Transdermal System (BTDS) in Children From 7 to 16 Years of Age, Inclusive, Who Require Continuous Opioid Analgesia for Moderate to Severe Pain
Principal Investigator: Dr. Beng Fuh
Funded By: Purdue Pharma L.P.