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Research

Cardiology

The Cardiology Section participates in several multi-center studies in a variety of cardiac disease processes.

Open Clinical Trials

North Carolina Congenital Defects Surveillance Network
The development of a population-based surveillance system of congenital heart defects across the lifespan in North Carolina with the goal of a high-quality surveillance system to monitor health services utilization and patient-centered outcomes for individuals with CHDs, to facilitate the development of novel interventions to improve health care delivery of CHD, including decreasing racial and ethnic disparities, and to partner with the CDC and similar funded projects in other states to enhance the quality and utility of CHD surveillance systems across the nation.

TOMORROW - pediaTric use Of Macitentan tO delay disease pRogRessiOn in PAH Worldwide
A multicenter, open-label, randomized, event-driven study to assess efficacy, safety and pharmacokinetics of macitentan versus standard of care in children with pulmonary arterial hypertension.

Selected Publications

Turner DR, Owada CY, Sang CJ, Khan M, Lim DS. Closure of Secundum Atrial Septal Defects With the AMPLATZER Septal Occluder: A Prospective, Multicenter, Post-Approval Study. Circ Cardiovasc Interv. 2017;10(8).

Hartman RJ. Noninvasive cardiovascular imaging. N C Med J. 2014 Mar;75(2):146-8.

Banka P, Sleeper LA, Atz AM, Cowley CG, Gallagher D, Gillespie MJ, et al. Practice variability and outcomes of coil embolization of aortopulmonary collaterals before Fontan completion: a report from the Pediatric Heart Network Fontan Cross-Sectional Study. Am Heart J. 2011 Jul;162(1):125-30.

Ellis AR, Reed JH, Fairbrother D. A tangled affair: pacemaker malfunction and syncope in a child due to Twiddler's syndrome. Cardiol Young. 2007 Apr;17(2):220-2.

Williams IA, Sleeper LA, Colan SD, Lu M, Stephenson EA, Newburger JW, et al. Functional state following the Fontan procedure. Cardiol Young. 2009 Aug;19(4):320-30.

Lipshultz SE, Sleeper LA, Towbin JA, Lowe AM, Orav EJ, Cox GF, et al. The incidence of pediatric cardiomyopathy in two regions of the United States. N Engl J Med. 2003 Apr 24;348(17):1647-55.

Kanter RJ, Graham M, Fairbrother D, Smith SV. Sudden cardiac death in young children with neurofibromatosis type 1. J Pediatr. 2006 Nov;149(5):718-20.

Feltes TF, Cabalka AK, Meissner HC, Piazza FM, Carlin DA, Top FH, et al. Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease. J Pediatr. 2003 Oct;143(4):532-40.

Atz AM, Lefler AK, Fairbrother DL, Uber WE, Bradley SM. Sildenafil augments the effect of inhaled nitric oxide for postoperative pulmonary hypertensive crises. J Thorac Cardiovasc Surg. 2002 Sep;124(3):628-9.

McConnell ME, Adkins SB, Hannon DW. Heart murmurs in pediatric patients: when do you refer? Am Fam Physician. 1999 Aug;60(2):558-65.