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Research

Critical Care

The Critical Care Section is committed to patient-care and constantly strives to understand and determine best practices. Additionally, the section is active in the PALISI (Pediatric Acute Lung Injury and Sepsis Investigators) Network. The PALISI Network performs multi-center research studies to better describe disease processes, interventions and outcomes in children with critical illness.

Open Clinical Trials

Prevalence of Acute Rehab for Kids in the PICU
A national point prevalence study is to characterize the prevalence and characteristics of mobility/physical rehabilitation as part of routine clinical care for critically ill children in PICUs in the U.S.

PARDIE (Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology)
An observational, multi-centered, cross-sectional study of new cases to better understand the implications of the new definition of Pediatric Acute Respiratory Distress Syndrome (PARDS) on the incidence and epidemiology of PARDS. This study is supported by the PALISI Network.

A comparison between ventilation strategies for neonatal and pediatric patients on Extracorporeal Membrane Oxygenation (ECMO)
A single-center, randomized study of two different ventilation strategies for pediatric patients on ECMO to investigate the impact on the ECMO course and duration.

Complications in Children Undergoing Upper Endoscopy With and Without Placement of an Esophageal pH Monitor
A single-center study to describe respiratory complications during esophageal pH probe placement during routine endoscopies.

Femoral Venous Catheters in Children
A single-centered study to establish the prevalence of correctly placed femoral catheters with two Xrays views.

Comparison of pediatric vs. adult C02 sampling sets in intubated children
A single-centered study to compare the Covidien/Oridien EtCO2 in-line sampling devices (infant/neonate vs adult/pediatric) in children intubated/ventilated with a 4.5 ETT or smaller.

Frequency of Operative Intervention in Pediatric Traumatic Brain Injury
A single-center retrospective study to compare ECU pediatric TBI outcomes to the national trend regarding pediatric traumatic brain injury (TBI) outcomes (morbidity/mortality).

Selected Publications

Novotny WE, Harris GD, Fiordalisi I, Hudson S, Perkin RM. The impact of mannitol administration in pediatric DKA: A 22 year experience. Journal of Pediatric Critical Care 2015; 2(4):37-44.

Eldridge D, Ledoux M. Needs more salt: old hydration habits are hard to break. Lancet. 2015;385(9974):1159-1160.

Novotny WE, Perkin RM, Mukherjee D, Lantos JD. Mechanical ventilation for a child with quadriplegia. Pediatrics. 2014;134(3):593-597.

Perkin RM, Ledoux MR: Acute Severe Asthma. Pediatric Emergency Medicine Reports, 2013;18:4,1-16.

Ledoux MR, Perkin RM: Upper Airway Obstruction in Pediatrics. Pediatric Emergency Medicine Reports, 2012; 17:1, 1-11.

Fiordalisi I, Novotny WE, Holbert D, Finberg L, Harris GD, Critical Care Management Group. An 18-yr prospective study of pediatric diabetic ketoacidosis: an approach to minimizing the risk of brain herniation during treatment. Pediatr Diabetes. 2007;8(3):142-149.

Ugale J, Mata A, Meert KL, Sarnaik AP; Measured degree of dehydration in children and adolescents with type 1 diabetic ketoacidosis, Pediatric Crit Care Med. 2012 Mar;13(2).

Ugale J, RongkavilitC; An 11 year old with recurent orbital swelling. Orbital Pseudotumor. Pediatric Ann. 2008 Aug;37(8):523-5 PMID

Matthew R. Ledoux, M.D. and David Eldridge, M.D., Co-Contributors British Medical Journal, Best Practice Guidelines, Online Reference, Toxic Ingestions in Children.