Click here for our lab-specific web page
Overview of the DeWitt Lab:
Our environmental developmental neuroimmunotoxicology research program explores relationships between biological organisms and their developmental responses after exposure to environmental toxicants. Early life exposure to a variety of agents impacts the immune, nervous, and endocrine systems, resulting in altered development that may present as diseases or disorders in childhood. We are particularly interested in how impacts to the immune system lead to downstream effects on the nervous system. Please visit our lab-specific web page for more detailed information about our research program.
Ten most recent manuscripts:
Hu Q, Franklin JN, Bryan I, Morris E, Wood A, and DeWitt JC. 2012. Does developmental exposure to perflurooctanoic acid (PFOA) induce immunopathologies commonly observed in neurodevelopmental disorders? NeuroToxicology. 33:1491-1498.
Jiang Q, LustR, Strynar MJ, and DeWittJC. 2012. Perflurooctanoic acid induces developmental cardiotoxicity in chicken embryos and hatchlings. Toxicology. 293:97-106.
Fair PA, Stavros H-C, Mollenhauer MAM, DeWitt JC, Henry N, Kannan K, Mitchum G, Y SH, Bossart GD, Keil DE, and Peden-Adams MM. 2012. Immune function is modulated by DE-71, a commercial polybrominated diphenyl ether mixture, in female B6C3F1 mice. Journal of Immunotoxicology. 40:230-236.
DeWitt JC and Dietert RR. 2011. Response to "Theoretical aspects of autism: Causes - a review" by Ratajczak, HV (Journal of Immunotoxicology 8:68-79, 2011). Journal of Immunotoxicology. 8:195-197.
Hu Q, Strynar MJ, and DeWitt JC. 2010. Are developmentally-exposed C57BL/6 mice insensitive to suppression of TDAR by PFOA? Journal of Immunotoxicology. 7:344-349.
DeWitt JC, Copeland CB, and Luebke RW. 2009. Suppression of humoral immunity by perfluorooctanoic acid is independent of elevated serum corticosterone concentration in mice. Toxicological Sciences. 109:106-112.
Peden-Adams MM, Stuckey JE, Gaworecki K, Berger-Ritchie J, Bryant K, Jodice PG, Scott TR, Boone S, McGuinn WD, DeWitt JC, and Keil DE. 2009. Developmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane sulfonate (PFOS). Reproductive Toxicology. 27:307-318.
Whalen MM, DeWitt JC, Luebke RW. 2008. Serum supplementation modulates the effects of dibutyltin on human natural killer cell function. Toxicological Sciences. 104:312-319.
DeWitt JC, Copeland CB, Strynar MJ, and Luebke RW. 2008. Perflurooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6 female mice. Environmental Health Perspectives. 116:644-650.
DeWitt JC, Copeland CB, and Luebke RW. 2008. An organotin mixture found in polyvinyl chloride (PVC) pipe is not immunotoxic to adult Sprague-Dawley rats. Journal of Toxicology and Environmental Health Part A. 71:276-282.
DeWitt J, Peden-Adams M, Keller J, and Germolec D. 2012. The immunotoxicity of perfluorinated compounds: Recent developments. 2011. Toxicologic Pathology, 40:300-311.
DeWitt J, Peden-Adams M, Keil D, and Dietert R. 2012. Current status of developmental immunotoxicity: Early-life patterns and testing. 2011. Toxicologic Pathology, 40:230-236.
Dietert RR, Dietert J, and DeWitt JC. 2011. Environmental risk factors for autism. Emerging Health Threats Journal (invited review). 4:7111.
Dietert RR, DeWitt JC, Germolec DR, and Zelikoff JT. 2010. Breaking patterns of environmentally influenced disease for health risk reduction: Immune perspectives. Environmental Health Perspectives 118:1091-1099.
DeWitt JC, Shnyra A, Badr MZ, Loveless SE, Hoban D, Frame SR, Cunard R, Anderson SE, Meade BJ, Peden-Adams MM, Luebke RW, and Luster MI. 2009. Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator activated receptor alpha. Critical Reviews in Toxicology 39:76-94.
Dietert RR, DeWitt JC, and Luebke RW. 2012. Reducing the prevalence of immune-based chronic disease. In: Immunotoxicity, Immune Dysfunction, and Chronic Diseases (Dietert RR and Luebke RW, eds), Molecular and Integrative Toxicology, Springer Science + Business Media, LLC. pp 419-440.
DeWitt J, Peden-Adams M, Keil D, and Dietert R. 2012. Developmental immunotoxicity (DIT): Assays for evaluating effects of exogenous agents on development of the immune system. In: Current Protocols in Toxicology. Chapter 18: Unit 18.15.
Luebke RW, DeWitt JC, Germolec DR, Salazar KD, and Kerkvliet NI. 2012. Immunomodulation by persistent organic pollutants. In: Dioxins and Health, Including Other Persistent Organic Pollutants and Endocrine Disruptors, 3nd Edition (Schecter A, ed), John Wiley and Sons, Inc., Hoboken, NJ. pp 171-192.
DeWitt JC and Dietert RR. Postnatal immune dysfunction and its impact on growth parameters. 2012. In: Handbook of Growth and Growth Monitoring in Health and Disease (Preedy VR, ed), Springer, New York, NY. pp 741-755.
DeWitt JC and Luebke RW. 2010. Immunological Aging. In: Comprehensive Toxicology, 2nd Edition, Volume 5 (Lawrence D, ed), Elsevier Limited, Oxford, UK. pp 455-465.
Dietert RR and DeWitt J. 2010. Developmental immunotoxicity (DIT): The why, where and how of DIT testing. In: Immunotoxicity Testing: Methods and Protocols (Dietert RR, ed), Methods in Molecular Biology. Humana Press, Inc., Totowa, NJ. 598:17-25.
Luebke RW, Beamer CA, Bowman C, DeWitt JC, Gowdy K, Johnson VJ, Shepherd DM, and Germolec DR. 2009. Immunotoxicology (developmental immunotoxicology section). In: General and Applied Toxicology, 3rd Edition (Marrs T, Ballantyne B, Syversen T, eds.), John Wiley & Sons, Ltd., Chichester, UK, pp 1561-1583.
Current Laboratory Members:
Qing Hu, Research Specialist
Jason Franklin, Ph.D. Candidate
Ian Bryan, Medical Student
Annalise vonderEmbse, Master's student
The Bureau of Land Management through a sub-contract with the University of Nevada at Las Vegas (2011-2014)
Project Title: Nellis Dunes Recreational Area Dust Exposure and Human Health Risk Assessment
The Harriet and John Wooten Laboratory for Alzheimer's and Neurodegenerative Diseases Research (2013-2014)
Project Title: Microglia as a Target of Environment x Gene Interactions