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Department of Pharmacology and Toxicology


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Dionne,-Raymond-web

Dr. Raymond A. Dionne

Research
Professor
e-mail:
dionner@ecu.edu

Publications

Salingan, L.N., Hsiao, C.P., Wang, D., Wang, X.M., St John, L., Kaushal, A., Citrin, D., Barbb, J.J., Munson, P.J. and Dionne, R.A.:  Upregulation of α-synuclein during localized radiation therapy signals the association of cnacer-related fatigue with the activation of inflammatory and neuroprotective pathways. Brain Behav Immun, 27: 63-70, 2013.

Wang, D., Kim, H., Wang, X.M. and Dionne, R.:  Genomic methods for clinical and translational pain research. In: Pain Research: Methods and Protocols, Methods in Molecular Biology, Ed: Z.D. Luo, Springer Science+Business Media, Secaucus, NJ, pp 9-46, 2012.

Wang, X.M., Hamza, M., Wu, T.X. and Dionne, R.A.:Upregulation of IL-6, IL-8 and CCL2 gene expression after acute inflammation:correlation to clinical pain.Pain. 142: 275-283, 2009.

Kim, H., Clark, D. and Dionne, R.A.:Genetic contributions to clinical pain and analgesia:avoiding pitfalls in genetic research.J. Pain. 10: 663-693, 2009.

Kim, H., Ramsay, E., Lee, H., Wahl, S. and Dionne, R.A.:Genome-wide association study of acute post-surgical pain in humans.Pharmacogenomics. 10: 171-179, 2009.

Gordon, S.M., Chuang, B.P., Wang, X.M., Hamza, M.A., Rowan, J.S., Brahim, J.S. and Dionne, R.A.:The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model.Anesth. Analg. 106: 321-327, 2008.

Wang, X.M., Hamza, M., Gordon, S.M., Wahl, S.M. and Dionne, R.A.:COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain. Clin. Pharmacol. Ther. 84: 39-42, 2008.

Woodcock, J., Witter, J. and Dionne, R.A.: Stimulating the development of mechanism-based, individualized pain therapies. Nat. Rev. Drug Discov. 6: 703-710, 2007.

Lee, Y.S., Kim, H., Brahim, J.S., Rowan, J., Lee, G. and Dionne, R.A.: Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical modle of acute inflammation. Pain. 129: 279-286, 2007.

Khan, A.A., Iadarola, M., Yang, H.Y. and Dionne, R.A.: Expression of COX-1 and COX-2 in a clinical model of acute inflammation. J. Pain. 8: 349-354, 2007.

Kim, H. and Dionne, R.A.: Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans. Mol. Pain. 3:6, 2007.

Wang, X.M., Wu, T.X., Hamza, M., Ramsay, E.S., Wahl, S.M. and Dionne, R.A.: Rofexocib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 128: 136-147, 2007.

Kim, H., Mittal, D.P., Iadarola, M.J. and Dionne, R.A.:Genetic predictors for acute experimental cold and heat pain sensitivity in humans. J. Med. Genet. 43: e40, 2006.

Lee, Y.S., Kim, H., Wu, T.X., Wang, X.M. and Dionne, R.A.: Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs. Clin. Pharmacol. Ther. 79: 407-418, 2006.

Wang, X.M., Wu, T.X., Lee, Y.S. and Dionne, R.A.: Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans:implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin. Pharmacol. Ther. 79: 303-315, 2006.