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Department of Pharmacology and Toxicology


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Domico1

Dr. Lisa M. Domico

Teaching Instructor, Toxicologist
e-mail:
domicol@ecu.edu
voice: 252-744-3301

 

Education:

B.S. – Chestnut Hill College, biology and environmental science
M.S. – University of Florida, College of Veterinary Medicine, Pathobiology
Ph.D. – Rutgers, The State University of New Jersey, Joint Graduate Program in Toxicology, neuro- and environmental toxicology
Post-Doctoral Fellowship – Children's Hospital of Philadelphia/University of Pennsylvania

Research Interests:

My particular interests lie in environmental toxicology and the mechanism(s) by which exposure to environmental agents are correlated with disease. I have studied ROS-producing agents, namely pesticides, as they relate to mitochondrial function, cell signaling, apoptosis, and disease progression. In addition, I am interested in the role of pesticide exposure in diabetes and obesity.


Publications:

Yang I, Domico LM, Sang S, Yang CS, Buckley BT. P118-S direct infusion mass spectrometry for biomarker detection of an unstable pesticide in cells and tea metabolites in plasma. J Biomol Tech 2007;18:41.

Domico LM, Cooper KR, Bernard LP, Zeevalk GD. Reactive oxygen species generation by the ethylene-bis-dithiocarbamate fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology 2007;28:1079-91.

Domico LM, Zeevalk GD, Bernard LP, Cooper KR. Acute neurotoxic effects of mancozeb and maneb in mesencephalic cells are associated with mitochondrial dysfunction. Neurotoxicology 2006;27:816-25.

Domico LM, Zeevalk GD, Yang I, Buckley B, Johnson W, Bernard LP, Thiruchelvam M, Cooper KR. The role of oxidative stress in the neurotoxicity of mancozeb and maneb. Proceedings of the Annual Meeting of the Society of Toxicology, San Diego, CA 2006. Abstract and poster presentation #1484.

Domico L, Zeevalk G, Buckley B, Winnik B, Thiruchelvam M, Cooper KR. Mancozeb and maneb neurotoxicity in mesencephalic cells: possible risk factor for parkinsonism. Proceedings of 2005 22nd International Neurotoxicology Conference, Research Triangle Park, NC 2005. Abstract and poster presentation #P-112.

Domico L, Zeevalk G, Buckley B, Winnik B, Thiruchelvam M, Cooper KR. Mancozeb and maneb neurotoxicity in mesencephalic cells: possible risk factor for parkinsonism  (abstract). Proceedings of 2005 Society for Neuroscience, Washington DC 2005. Abstract and poster presentation #425.12.

Domico L, Zeevalk G, Thiruchelvam M, Cooper KR. Neurotoxic effects of mancozeb and maneb in vivo and in vitro. Proceedings of 2005 Hudson-Delaware Chapter of Society of Environmental Toxicology and Chemistry, New Brunswick, NJ 2005. Abstract and poster presentation.

Domico L, Zeevalk G, Thiruchelvam M, Cooper KR. Neurotoxic effects of mancozeb and maneb in vivo and in vitro. Proceedings of the Annual Meeting of the Society of Toxicology, New Orleans, LA 2005. Abstract and poster presentation #1965.

Domico L, Homer B, Berry K, Cousins R, Jacobson E, Klein P, Williams E. Purification of desert tortoise (Gopherus agassizii) metallothionein, a potential biomarker of heavy metal exposure. Proceedings of 2001 Annual Desert Tortoise Council Symposium, Tucson, AZ 2001. Abstract pp 11-12.