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Department of Pharmacology and Toxicology




 


Gibson_fish

Dr. James E. Gibson

Research Professor
e-mail:
gibsonj@ecu.edu
voice: 252-744-9691

 

Our laboratory has two major thrusts, each of which is dependent on core capabilities in the characterization of toxicity and exposure. First, the hazards associated with exposure to marine toxins such as the brevetoxins and their antagonists of toxicity, namely, cytotoxicity, chromosomal aberration, embryotoxicity or teratogenicity, cell transformation, DNA damage, estrogenicity, and neurotoxicity.  Additionally, we serve the Oceans and Human Health Initiative by providing resources to solve problems specific to their activities, but primarily to characterize the biological activity of substances collected from the oceans. Further characterization of mechanisms of pharmacological or toxicological activity will be through the use of the techniques of panomics. Second, regulatory bodies are now requiring consideration of risk in the cumulative for nanomaterials, which requires new assessments of hazards because of chemical interactions and new assessments of exposure considering exposure to more than one substance at a time. We are designing work to learn how worker substance exposures might be estimated in the cumulative and compared to relevant toxicological dose levels under conditions of actual use. This will provide guidance for better characterization of exposure in studies of multiple substances.

Publications
Monticello, T. M., Swenberg, J. A., Gross, E. A., Leininger, J. R., Kimbell, J. S., Seilkop, S., Starr, T. B., Gibson, J. E., and Morgan, K. T. (1996). Correlations of Regional and Nonlinear Formaldehyde-Induced Cancer with Proliferating Populations of Cells. Cancer Res. 56, pp. 1012-1022.

Gibson, J.E., Peterson, Robert K., and Shurdut, Bradley A. (1998) Human Exposure and Risk from Indoor Use of Chlorpyrifos. Environmental Health Perspectives, 106 (5)303-306.

Monticello, T. M., Swenberg, J. A., Gross, E. A., Leininger, J. R., Kimbell, J. S., Seilkop, S., Starr, T. B., Gibson, J. E., and Morgan, K. T. (1996). Correlations of Regional and Nonlinear Formaldehyde-Induced Cancer with Proliferating Populations of Cells. Cancer Res. 56, pp.
1012-1022.

Gibson, J.E., Peterson, Robert K., and Shurdut, Bradley A. (1998) Human Exposure and Risk from Indoor Use of Chlorpyrifos. Environmental Health Perspectives, 106 (5)303-306.

Gibson J.E., Chen W.L., and Peterson R.K.D. (1999) How to determine if an additional 10x safety factor is needed for chemicals: A case study with chlorpyrifos. Toxicological Sciences, 48,117.

Oliver, G.R., Gibson, J.E., Wolt, J.D., Shanahan, D.M. (2000) Biotech foods: A closed and reopened case. Chemical Innovation, 30 (7) 12-19.

Mattsson, J.L., Holden, L, Eisenbrandt, D.L., Gibson, J.E. (2001) Reanalysis with optimized power of red blood cell acetylcholinesterase activity from a 1-year dietary treatment of dogs to chlorpyrifos. Toxicology,160: 155-164.

Sayer, A.N., Hu, Q., Bourdelais, A. J., Baden, D. G., Gibson, J.E. (2005) The effect of Brevenal on Brevetoxin induced DNA damage in human lymphocytes. Arch. Tox. 79:683-688.

 

Gibson, J.E. and Taylor, D.A. (2005) Can claims, misleading information and manufacturing issues regarding dietary supplements be improved in the United States of America? J. Pharmacol. Exptl. Therap. 314:939-944.

 

Sayer, A.N., Hu, Q., Bourdelais, A.J., Baden, D.G., and Gibson, J.E. (2006) The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro. Food and Chemical Toxicology, 44/7:1082-1091.

 

Gibson, J.E. (2006) Editorial. HESI Bioinformatics Workshop. Mol. Nutr. Food Res. 50: 591.

 

Murrell, R.N. and J. E. Gibson. (2009) Brevetoxins 2, 3, 6, and 9 show variability in potency and cause significant induction of DNA damage and apoptosis in Jurkat E6-1 cells.  Archives of Toxicology 83:1009-1019.

 

Murrell, R.N. and Gibson, J.E. (2009) Brevetoxin 2, 3, 6, and 9 cause significant induction of apoptosis in Jurkat E6-1 cells.  In Submission.

 

Murrell, R.N. and Gibson, J.E. (2009)  Brevetoxin 2 alters expression of apoptotic genes, DNA damage repair genes and Cytokine genes in Jurkat E6-1 Cells.  In preparation.

 

Murrell, R.N., Masterson, J.and Gibson, J.E. (2009) Cell response to brevenal is dependent on voltage gated sodium channel subtype.  In preparation.

 

 

 

 
Laboratory Members

Jackie Masterson, Research Specialist
Rachel Murrell, Post Doctoral Fellow