Dept. of Pharmacology & Toxicology, Mail Stop 633
The Brody School of Medicine
East Carolina University
600 Moye Blvd., Greenville, NC 27864
Ph.D., School of Veterinary Medicine, Louisiana State University
M.V.Sc., ANGR Agricultural University, Hyderabad, India
B.V.Sc. & A.H., ANGR Agricultural University, Hyderabad, India
The current research in our laboratory is focused on understanding the central neural mechanisms involved in the regulation of blood pressure. In particular, we are investigating the roleof kinin B1 receptor activation and its interaction with Renin Angiotensin System components in the development of neurogenic hypertension. Our laboratory uses an integrated physiological, pharmacological, and gene-targeting approach, employing in vivo animal models of human diseases, complemented by in vitro primary cell cultures and cell lines. Some of the techniques used in our lab include blood pressure and heart rate recordings in conscious free moving mice using telemetry system, autonomic function assessment, brain nuclei-targeted microinjections, electron/fluorescence microscopy, and routine cell and molecular biology techniques. The major goal of our laboratory research is to elucidate mechanisms underlying the pathophysiology and identify novel potential therapeutic targets for the treatment of cardiovascular diseases.
· Kinin B1 receptor activation in inflammation and neurogenic hypertension
· Signaling mechanisms involved in interaction of kinins with the Renin Angiotensin System components in cardiovascular diseases
· Sex differences in hypertension and diabetes
For a full listof PubMed citations, click here.
1. Sriramula S*, Lazartigues E. Kinin B1 receptor promotes neurogenic hypertension through activation of centrally mediated mechanisms. Hypertension.2017 (in press; *Corresponding author).
2. Xu J, Sriramula S, Xia H, Moreno-Walton L, Culicchia F, Domenig O, Poglitsch M, Lazartigues E. Clinical relevance and role of neuronal AT1 receptors in ADAM17-mediated ACE2 shedding in neurogenic hypertension. Circulation Research.2017, 121:43-55.
3. Sriramula S*, Joseph Francis*. Tumor necrosis factor– alpha is essential for angiotensin II-induced ventricular remodeling: Rolefor oxidative stress. PLoS ONE. 2015,10(9):e0138372 (*Corresponding author).
4. Sriramula S, Xia H, Xu P, Lazartigues E.Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. Hypertension. 2015, 65(3):577-86.
5. Deshotels MR, Xia H, Sriramula S, Lazartigues E, Filipeanu CM. Angiotensin II mediates Angiotensin Converting Enzyme 2internalization and degradation through an Angiotensin II type 1receptor-dependent mechanism. Hypertension.2014, 64(6):1368-75.
6. Xia H*, Sriramula S*, Kavaljit H, Lazartigues E. Brain ACE2 shedding contributes to the development of neurogenic hypertension. Circulation Research. 2013, 113:1087-1096. (*Equal first authors)
7. Sriramula S, Cardinale JP, Francis J. Inhibition of TNF in the brain reverses alterations in RAS components and attenuates angiotensin II-induced hypertension. PLoS ONE. 2013, 8(5):e63847.
8. Cardinale JP, Sriramula S, Mariappan N,Agarwal D, Francis J. Angiotensin II-induced hypertension is modulated by Nuclear factor-kappa B in the paraventricular nucleus. Hypertension. 2012, 59(1):113-121.
9. Sriramula S, Cardinale JP, Lazartigues E, Francis J. ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension. Cardiovascular Research 2011, 92:401-8. (Editorial Comment by Olaf Grisk, Cardiovascular Research. 2011,92:365-366).
10. Shenoy V, Ferreira AJ, Qi Y, Fraga-Silva RA, Díez-Freire C, Dooies A, Jun JY, Sriramula S, Mariappan N, Pourang D, Venugopal CS, Francis J, Reudelhuber T, Santos RA, Patel JM, Raizada MK, Katovich MJ. The ACE2/Ang-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine. 2010, 182:1065-1072.
11. Shi P, Diez-Freire C, Jun JY, Qi Y,Katovich MJ, Li Q, Sriramula S,Francis J, Sumners C, Raizada MK. Brain microglial cytokines in neurogenic hypertension. Hypertension. 2010, 56(2):297-303.
12. Sriramula S, Haque M, Majid DS, Francis J.Involvement of Tumor Necrosis Factor-alpha in Angiotensin II-Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy. Hypertension. 2008, 51(5):1345-1351.
2011 Annual High Blood Pressure Research Conference New Investigator Award
2012 American Physiological Society Central Nervous System Research Recognition Award
2012 High Blood Pressure Research Conference New Investigator Travel Award for Trainees
2013 Neural Control and Autonomic RegulationSection Postdoctoral and Early Career Research RecognitionAward from American Physiological Society
2014 American Physiological Society Cardiovascular Section Research Recognition Award
2015 American Physiological Society Caroline tum Suden/Francis A. Hellebrandt Professional OpportunityAward
07/01/2015-06/30/2018 American Heart Association Scientist Development Grant 15SDG25720021, Role: PI; “Roleof bradykinin B1 receptor in neurogenic hypertension”
07/01/2013-6/30/2015 American Heart Association Postdoctoral Fellowship
13POST16500025, Role: PI; “Role of bradykinin peptides in ACE2-mediated modulation of neurogenic hypertension”