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Joseph McClung

Assistant Professor
Department of Physiology
Phone: 252-737-5034
Email: mcclungj@ecu.edu

Education/Employment

  • 2013-present Assistant Professor Department of Physiology Brody School of Medicine, East Carolina University
  • 2010-2013 Senior Research Associate, Division of Cardiology, Duke University Medical Center
  • 2008-2010 Postdoctoral Fellow, Duke University Medical Center
  • 2005-2008 Postdoctoral Associate, University of Florida
  • 2005 Doctorate of Philosophy, Applied Physiology, University of South Carolina

Publications

Complete List of Published Work

Ryan, T.E., C.A. Schmidt, R.J. Alleman, L.R. Reese, A.M. Tsang, T.D. Green, P.D. Neufer, D.A. Brown, & J.M. McClung* . "Mitochondrial therapy rescues limb perfusion and myopathy in hindlimb ischemia". Accepted/In Press - J. Molecular & Cellular Cardiology, Jun 1;97:191-196. doi: 10.1016/j.yjmcc.2016.05.015. *Corresponding Author

Ryan T.E., C.A. Schmidt, T.D. Green, E.E. Spangenburg, P.D. Neufer, & J.M. McClung* . "Targeted overexpression of mitochondrial catalase protects against ischemic myopathy in high fat fed mice". Accepted/In Press - Diabetes. 2016 Jun 9. pii: db160387 *Corresponding Author

Schmidt, C.A., T.E. Ryan, Chien-Te Lin, M.M.R. Inigo, T.D. Green, J.J. Brault, E.E. Spangenburg, & J.M. McClung* . "Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia". Accepted/In Press - J Vasc. Surgery, May 2016 . *Corresponding Author

R. Alleman, A. Tsang, T.E. Ryan, D.J. Patterson, J.M. McClung , E.E. Spangenburg, S.R. Shaikh, P.D. Neufer, & D.A. Brown. "Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics". Am. J. Physiol. Heart Circ. Physiol . 2016 May 15;310(10):H1360-70 .

Ryan T.E., C.A. Schmidt, T.D. Green, D.A. Brown, P.D. Neufer, & J.M. McClung* . "Mitochondrial Regulation of the Muscle Microenvironment in Critical Limb Ischemia. Front Physiol. 2015 Nov 18;6:336. doi: 10.3389/fphys.2015.00336. Review. *Corresponding Author

McClung, J.M., T.J. McCord, S. Keum, D.A. Marchuk, D. Bowles, B.H. Annex, S. Johnson, & C.D. Kontos. Differential Limb Vascular and Muscle Cell Response to Insult Determines Strain Dependent Pathology with Ischemia". Am J Pathol. 2012 May;180(5):2156-69 .

Shen, J., C. Seidel, M. Frye, B.L. Lee, J.M. McClung , R.L. e Silva, A. Dong, S.F. Hackett, B.H. Howard, D.Vestweber, C.D. Kontos, K.G. Peters, P.A. Campochiaro. "Vascular Stabilization by Inhibition of Vascular Endothelial Protein Tyrosine Phosphatase". J Clin Invest. 2014 Oct 1;124(10):4564-76.

McClung, J.M.* , J. Reinardy, S. Mueller, T.J. McCord, C.D. Kontos, D.A. Brown, S.N.A. Hussain, C.A. Schmidt, T.E.Ryan, & T.D. Green. "Paracrine Signaling by Traditional Vascular Growth Factors with Ischemia Contributes to both Myogenesis and Angiogenesis". Front. Physiol.-Vascular Physiol. (2015) 6:161.doi: 10.3389/fphys.2015.00161. *Corresponding Author

McClung, J.M. *, T.J. McCord, K. Southerland, C.A. Schmidt, M.E. Padgett, T.E. Ryan, & C.D. Kontos. "Subacute Limb Ischemia Induces Skeletal Muscle Injury in Genetically Susceptible Mice Independent of Vascular Density". Journal of Vascular Surgery 2015 Aug 5. pii: S0741-5214(15)01384-1. *Corresponding Author

Padgett, M.E., T.J. McCord, J.M. McClung , & C.D. Kontos. "Methods for Acute and Subacute Murine Hindlimb Ischemia". Accepted/In Press - JoVE, http://www.jove.com/video/54166 ; May 2016.

Research Support

R00-HL103797 (PI: McClung ) NIH/NHLBI K99/R00 Pathway to Independence Award Peripheral endothelial and muscle cell pathology in cardiovascular disease Department of Physiology, East Carolina University, Brody School of Medicine, Greenville, NC.

R01-HL201725 (PI: Kontos, Co-I: McClung ) National Institutes of Health VEGF Cognate Receptor Signaling in Resident Muscle Progenitor Cells During Ischemia Division of Cardiology, Duke University Medical Center

R01-HL125695 (PI: McClung ) NHLBI, National Institutes of Health Genetic Determinants of Limb Pathology in Peripheral Artery Disease Department of Physiology, East Carolina University, Brody School of Medicine, Greenville, NC.

1 F32 HL129632-01A1 (Trainee: Ryan, T.E., Mentor: McClung ) 4/01/2016-3/31/2018 NHLBI T32 Ruth L. Kirschstein NRSA Individual Postdoctoral Fellowship The role of skeletal muscle mitochondrial function in ischemic tissue pathology of peripheral arterial disease. Department of Physiology, East Carolina University, Brody School of Medicine, Greenville, NC.

Brody School of Medicine Internal Seed/Bridge Grant (PI: McClung ) Brody School of Medicine / East Carolina University Internal Grant Award Muscle Mitochondria in Vascular Disease East Carolina University, Brody School of Medicine, Greenville, NC.

Brody School of Medicine Cell Sorter Grant (PI: Gowdy, CoI/Major User: McClung ) NIH Shared Instrumentation Grant (S10) East Carolina University, Brody School of Medicine, Greenville, NC.

North Carolina Biotechnology Center (PI: Virag, CoI/Major User: McClung ) Institutional Development Grant Automated Slide Scanning to Enhance Research Infrastructure and Throughput at East Carolina University East Carolina University, Brody School of Medicine, Greenville, NC.