Brody School of Medicine, 6N-84
Department of Physiology
600 Moye Blvd.
Greenville, NC 27834
My laboratory pursues multidisciplinary research projects centered around impacts of extrinsic factors on cardiopulmonary function. In collaboration with Dr. Wardle and scientists in pharmaceutical and biotechnology industries, we conduct preclinical testing of novel therapeutics for the treatment of asthma and opiate-induced respiratory depression. The group pursues studies into the mechanisms underlying asthma and respiratory control, ways to improve the predictive value of animal models of respiratory disease, and assessment of the therapeutic potential of emerging drug candidates. In collaboration with scientists at the US EPA and Drs. Wingard, Brown, and Lust at ECU we investigate the impact of allergens and particulate air pollution on cardiovascular function. Observations reveal that airborne allergens and particulate pollution alter vascular reactivity and increase the severity of adverse cardiac events, such as myocardial infarction. The group is currently pursuing investigations into the transduction processes by which particulate exposure alters cardiovascular function.
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Master Research Agreements with: