Dr. Ruth Ann Henriksen, Ph.D.
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Research Professor
Department of Physiology
Associate Professor Emeritus
Department of Internal Medicine |
Phone: (252) 744-3155
Fax: (252) 744-3481
Email: henriksenr@ecu.edu
Mailing Address:
Brody School of Medicine
Department of Physiology
600 Moye Blvd.
Greenville, NC 27834
Research Interest Thrombosis and hemostasis
Platelets
Protease activated receptors
Inflammation
Macrophage activation
Atherosclerosis
Employment/Education Ph.D., University of Iowa, Biochemistry, 1985.
M.S., University of Washington, Biochemistry, 1964.
B.S., Seattle Pacific College, Chemistry, 1961.
1994-2002, Associate Professor, East Carolina University, Brody School of Medicine, Internal Medicine, Allergy, Immunology and Rheumatology
1988-1994, Assistant Professor, East Carolina University, Brody School of Medicine, Medicine, Allergy/Immunology
Publications
- Nishiyama A, Tsuji S, Yamashita M, Henriksen RA, Myrvik QN, Shibata Y (2006) Phagocytosis of N-acetyl-D-glucosamine particles, a Th1 adjuvant, by RAW 264.7 cells results in MAPK activation and TNF-α, but not IL-10, production, Cellular Immunology, 239, 103-112
- Shibata Y, Nishiyama A, Ohata H, Gabbard J, Myrvik QN, Henriksen RA (Apr 2005) Differential effects of IL-10 on prostaglandin H synthase-2 expression and prostaglandin E2 biosynthesis between spleen and bone marrow macrophages., Journal of Leukocyte Biology, 77 (4), 544-51 Abstract
- Shibata Y, Henriksen RA, Honda I, Nakamura R M, Myrvik QN (2005) Splenic PGE2-releasing macrophages regulate Th1 and Th2 immune responses in mice treated with heat-killed BCG, Journal of Leukocyte Biology, 78, 1281-1290
- Henriksen RA, Hanks VK, PAR-4 Agonist AYPGKF Stimulates Thromboxane Production by Human Platelets, Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 861-866, 2002
- Ispas L, Henriksen RA, Metzger WJ, The many faces of systemic mastocytosis, Annals of Allergy, Asthma, and Immunology, 87, 6-15, July 2001
- Samokhin GP, Jirousek MR, Ways DK, Henriksen RA, Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets, European Journal of Pharmacology, 386, 297-303, 1999
- Henriksen RA, Dunham CK, Miller LD, Casey JT, Menke JB, Knupp CL, Usala SJ, Prothrombin Greenville, Arg517-->Gln, identified in an individual heterozygous for dysprothrombinemia, Blood, 91(6), 2026-31, 15 Mar 1998
- Henriksen RA, Samokhin GP, Tracy PB, Thrombin-induced thromboxane synthesis by human platelets. Properties of anion binding exosite I-independent receptor [published erratum appears in Arterioscler Thromb Vasc Biol 1998 Jul;18(7):1198, Arteriosclerosis, Thrombosis, and Vascular Biology, 17(12), 3519-26, December 1997
- Henriksen RA, Mann KG (1989) Substitution of Val for Gly-558 in the congenital dysthrombin, thrombin Quick II alters primary substrate specificity, Biochemistry, 28, 2078-2082
- Henriksen RA, Mann KG (1988) Identification of the primary structural defect in the dysthrombin, thrombin Quick I: Substitution of Cys for Arg. 382, Biochemistry, 27, 9160-9165
- Henriksen RA, Owen WG (1987) Characterization of the catalytic defect in the dysthrombin, thrombin Quick, J Biol Chem, 262, 4664-4669
Memberships American Association of University Professors
American Chemical Society
American Society for Biochemistry and Molecular Biology
Council on Arteriosclerosis, Thrombosis and Vascular Biology, FAHA
Sigma Xi, The Scientific Research Society |
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