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Brody School of Medicine
Department of Physiology


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Dr. Edward M. Liberman, Ph.D.
  Professor Emeritus
Department of Physiology

Phone: (252) 744-2771
Fax: (252) 744-3460
Email: LiebermanE@ecu.edu

Mailing Address:
Brody School of Medicine, 6W-43
Department of Physiology
600 Moye Blvd.
Greenville, NC 27834
 
Research Interests
  • The Physiological Basis for Neuron-Glia Interactions
  • Perineural Potassium Ion Homeostasis
  • Metabolic Properties of Nerve and Glia
  • NAAG, Glutanate +NO-induced nerotoxicity
 
Employment/Education
1959  B.S., Tufts University, Medford, MA
1961  M.S., University of Massachusetts, Amherst, MA
1965  Ph.D., University of Florida, Gainesville, FL
1966-1968  Swedish Medical Research Council Postdoctoral Fellow, University of Uppsala, Sweden
 
Publications
Recent

Urazaev A.K., Grossfeld R.M., Fletcher P.L., Speno H., Gafurov B.S., Buttram J.G., Lieberman E.M. (2001) Synthesis and release of N-acetylaspartylglutamate (NAAG) by crayfish nerve fibers: Implications for axon-glia signaling. Neuroscience 106(1): 237-247.

Gafurov B., Urazaev A.K., Grossfeld R.M., Lieberman E.M. (2001) N- acetylaspartylglutamate (NAAG) is the probable mediator of axon-to-glia signaling in the crayfish medial giant nerve fiber. Neuroscience 106(1): 227-235.

Gafurov B.S., Urazaev A.K., Grossfeld R.M., and Lieberman E.M. (2002) Mechanism of NMDA receptor contribution to axon-to-glia signaling in the crayfish medial giant nerve fiber. Glia 38:80-86

Urazaev A.K., Grossfeld R.M., and Lieberman E.M. (2005) Regulation of glutamate carboxypeptidase II hydrolysis of N-acetylaspartylglutamate (NAAG) in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors. J Neurochem. 93(3): 605-610

Beshay, J.E., Hahn, P., Beshay, V.E., Hargittai, P.T. and Lieberman, E.M. (2005) Activity-dependent change in the morphology of the glial tubular lattice of the crayfish medial giant nerve fiber. Glia 51:121-131

More Publications
Stewart, W.C., Pekala, P.H. and Lieberman, E.M. Acute and Chronic Regulation of Na+/K+- ATPase Transport Activity In The RN22 Schwann Cell Line. GLIA 23: 349-360 (1998)

Urazaev A.K., Buttram J.G., Deen J.P., Gafurov B.S., Slusher B.S., Grossfeld R.M., Lieberman E.M. (2001) Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: Implications for axon-glia signaling. Neuroscience 107(4):697-703.

Malomouzh A.I., Mukhtarov M.R., Nikolsky E.E., Vyskočil F., Lieberman E.M., Urazaev A.Kh. (2003) Glutamate regulation of non-quantal release of acetylcholine in the rat neuromuscular junction. J.Neurochem. 85:206-213.

Malomouzh, A.I., Nikolsky, E.E., Lieberman, E.M., Sherman, J.A., Lubischer, J., Grossfeld, R.M. and Urazaev, A.K. (2005) Effect of n-acetylaspartylglutamate (naag) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat. J. Neurochemistry 94:257-267

Olanrewaju HA, Gafurov BS, and Lieberman EM, (2002) Adenosine A2A and A2B receptors-mediated hyperpolarization in porcine coronary artery endothelial cells. J. Cardiovasc. Pharm. 40:43-49.

 
PubMed Publications
1: Beshay JE, Hahn P, Beshay VE, Hargittai PT, Lieberman EM.
Abstract Activity-dependent change in morphology of the glial tubular lattice of the crayfish medial giant nerve fiber.
Glia. 2005 Aug 1;51(2):121-31.
PMID: 15789432 [PubMed - indexed for MEDLINE]
2: Malomouzh AI, Nikolsky EE, Lieberman EM, Sherman JA, Lubischer JL, Grossfeld RM, Urazaev AKh.
Abstract Effect of N-acetylaspartylglutamate (NAAG) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat.
J Neurochem. 2005 Jul;94(1):257-67.
PMID: 15953368 [PubMed - indexed for MEDLINE]
3: Urazaev AK, Grossfeld RM, Lieberman EM.
Abstract Regulation of glutamate carboxypeptidase II hydrolysis of N-acetylaspartylglutamate (NAAG) in crayfish nervous tissue is mediated by glial glutamate and acetylcholine receptors.
J Neurochem. 2005 May;93(3):605-10.
PMID: 15836619 [PubMed - indexed for MEDLINE]
4: Malomouzh AI, Mukhtarov MR, Nikolsky EE, Vyskocil F, Lieberman EM, Urazaev AK.
Abstract Glutamate regulation of non-quantal release of acetylcholine in the rat neuromuscular junction.
J Neurochem. 2003 Apr;85(1):206-13.
PMID: 12641742 [PubMed - indexed for MEDLINE]
5: Buttram JG, Engler JA, Grossfeld RM, Urazaev AKh, Lieberman EM.
Abstract Glutamine uptake and metabolism to N-acetylaspartylglutamate (NAAG) by crayfish axons and glia.
Comp Biochem Physiol B Biochem Mol Biol. 2002 Oct;133(2):209-20.
PMID: 12381383 [PubMed - indexed for MEDLINE]