Dr. Michael R. Van Scott, Ph.D.  | Professor
Department of Physiology
| Phone: (252) 744-3654 Fax: (252) 744-3460 Email: vanscottmi@ecu.edu Mailing Address:
Brody School of Medicine, 6N-84
Department of Physiology
600 Moye Blvd.
Greenville, NC 27834
Research Interests Dr. Van Scott pursues three related multidisciplinary research projects. In collaboration with Dr. Wardle and scientists in pharmaceutical and biotechnology industries, he conducts preclinical testing of novel therapeutics for the treatment of asthma. The group pursues studies into the mechanisms underlying asthma, ways to improve the predictive value of asthma models, and assessment of the therapeutic potential of emerging drug candidates. The second project is conducted in conjunction with Dr. Jeff Fedan at the National Institute of Occupational Safety and Health and students at West Virginia University. Studies are performed at the Appalachian Laboratory for Occupational Safety and Health in Morgantown, WV, to better understand control of airway smooth muscle contraction and airway hyper-reactivity. The group is particularly interested in how changes in osmolarity within the airway surface liquid, as observed in exercise-induced asthma, affect release of relaxing factors from the epithelium lining the respiratory tract airway smooth muscle contractility. The third project involves collaboration with scientists at the US EPA and Drs. Wingard, Lust, and Cascio at ECU to investigate the impact of allergens and particulate air pollution on cardiovascular function. Early observations revealed that airborne allergens and particulate pollution alter vascular reactivity and increase the severity of adverse cardiac events, such as myocardial infarction. The group is currently pursuing investigations into the transduction processes by which particulate exposure alters cardiovascular function.
Education/Employment Professor (2000-present)
Associate Professor (1993-2000)
Assistant Professor (1990-1993)
Department of Physiology
Brody School of Medicine at East Carolina University
Greenville, NC
Research Assistant Professor (1986-1990)
Department of Medicine
Division of Pulmonary Diseases
University of North Carolina at Chapel Hill, NC
Post-doctoral Fellowship (1984-1986)
Division of Pulmonary Diseases
Department of Medicine
University of North Carolina, Chapel Hill, NC
Doctor of Philosophy in Physiology (1984)
West Virginia University
Morgantown, WV
Research training (1982-1984)
National Institute of Occupational Safety and Health
Appalachian Laboratory for Occupational Safety and Health
Morgantown, WV
Bachelor of Science, Biology (1981)
Cornell University
Ithaca, NY
Medical Corpsman (1978-1979)
82nd Airborne Division
United States Army, Fort Bragg, NC
Photochemical technician (1977-1978)
Eastman Kodak Company
Rochester, NY
Patents Pending: Device to Measure Muscle Contractile/Relaxant and Epithelial Bioelectric Responses of Perfused, Intact Airways In Vitro, CDC Tech ID No. I-004-05, Co-inventor.
Selected Publications Hazarika, S., M.R. Van Scott, and R.M. Lust. Myocardial ischemia-reperfusion injury is enhanced in a model of systemic allergy and asthma. Am J Physiol Heart Circ Physiol. 286(5):H1720-H1725, 2004 (10.1152/ajpheart.01064.2003). Van Scott, M.R., D. Aycock, E. Cozzi, K. Salleng, and H.W. Stallings. Separation of bronchoconstriction from increased ventilatory drive in a nonhuman primate model of chronic allergic asthma. J. Applied Physiol. 99(6):2080-6, 2005. (10.1152/japplphysiol.00537.2005; http://jap.physiology.org/cgi/reprint/00537.2005v1) Cozzi E., S. Hazarika , H.W. Stallings III, W.E. Cascio, R.B. Devlin, R.M. Lust, C.J. Wingard, M.R. Van Scott. Ultrafine particulate matter exposure augments ischemia reperfusion injury in mice. Am J Physiol Heart Circ Physiol. 291(2):H894-903, 2006 ( http://ajpheart.physiology.org/cgi/reprint/01362.2005v1). Fedan, J.S., D.X-Y Wu, and M.R. Van Scott, and. Altered Ion transport and responsiveness to methacholine and hyperosmolarity in air-liquid interface-cultured guinea-pig tracheal epithelium. Journal of Pharmacology and Experimental Therapeutics 55(2):135-43, 2007. Hazarika, S., M.R. Van Scott, and R.M. Lust. Severity of myocardial injury following ischemia-reperfusion is increased in a mouse model of allergic asthma. Am J Physiol Heart Circ Physiol Am J Physiol Heart Circ Physiol. 292(1):H572-9, 2007. Murashov, A.K., V. Chintalgattu, R.R. Islamov, T.E. Lever, E.S. Pak, P.L. Sierpinski, L.C. Katwa, and M.R. Van Scott, RNAi Pathway is Functional in Peripheral Nerve Axons, FASEB J. 21(3):656-70, 2007. Cozzi, E., C.J. Wingard, W.E. Cascio, R.B. Devlin, J.J. Miles, R.M. Lust, M.R. Van Scott, and R.A. Henriksen. Exposure to ultrafine particulate matter increases thrombogenic potential. Translational Research 149(6):324-32, 2007. Jing, Y., J.A. Dowdy, M.R. Van Scott, and J.S. Fedan. Hyperosmolarity-induced dilation and epithelial bioelectric responses of guinea-pig trachea in vitro. Role of kinase signaling J Pharmacol Exp Ther. 326(1):186-95, 2008. (0.1124/jpet.107.135871) Jing, Y., J.A. Dowdy, M.R. Van Scott, and J.S. Fedan. Simultaneous measurement of mechanical responses and transepithelial potential difference and resistance, in guinea-pig isolated, perfused trachea using a novel apparatus: pharmacological characterization. European Journal of Pharmacology 598:98-103, 2008 (10.1016/j.ejphar.2008.09.009)
Van Scott, M.R., E. Mertsching, E. Negrou, J. Miles, H. Stallings, C. Graff; M. Kehry. Systemic administration of an Fc-Fc- fusion protein in house dust mite sensitive nonhuman primates. Clinical Immunology 128:34-348, 2008.
PubMed Publications | 2: | Ball HA, Van Scott MR, Robinson CB. |
|  | Sense and antisense: therapeutic potential of oligonucleotides and interference RNA in asthma and allergic disorders.
Clin Rev Allergy Immunol. 2004 Dec;27(3):207-17. Review.
PMID: 15630157 [PubMed - indexed for MEDLINE] | | 3: | Hazarika S, Van Scott MR, Lust RM. |
|  | Myocardial ischemia-reperfusion injury is enhanced in a model of systemic allergy and asthma.
Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1720-5. Epub 2004 Jan 8.
PMID: 14715513 [PubMed - indexed for MEDLINE] |
Research Programs Respiratory, Cell and Molecular Physiology
Functions of Airway Epithelia
Mechanisms Underling Airway Hyperresponsiveness and Asthma
Animal Models of Airway Inflamation and Asthma
Major Techniques Employed
Western Blot, Northern Blot, PCR
Immunofluorescence, Immunohistochemistry
In situ hybridization
Current Lab Personnel
Dr. Yoshimi Shibata
Cynthia Kukoly
Jerry Hooker
David Ehrmann
Pragna Mehta, Technical Staff
Present Funding
Contract: EpiGenesis Pharmaceuticals,
"Respirable Antisense Oligonucleotides in the Treatment of Asthma"
M.R. Van Scott, P.I.
July 1, 2000 - 2003
NC Biotechnology Center, Collaborative Assistance Program,
"Antisense to GATA-3 in Allergic Airways Diseases"
M.R. Van Scott, P.I., P. Mehlhop, co-PI.
September 15, 1999 - September 14, 2000.
Pending:
NIH R01, "Chitin has Th1 adjuvant effects on mycobacterial antigen"
Y. Shibata, P.I., M.R. Van Scott, Co-PI @ 10% effort.
April 1, 2001 - March 31, 2005.
NIH R01, "Chitin-activated macrophages down-regulate Th2 responses"
Y. Shibata, P.I., C.J. Kovacs, co-I., M.R. Van Scott, co-I.
December 1, 2000 - November 30, 2004.
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