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Division of Health SciencesThe Harriet and John Wooten Laboratory

Health Sciences Campus

Recent Publications supported by the Wooten Laboratory

Lu Q, Ding K, Frosch MP, Jones S, Wolfe M, Xia W, Lanford GW. Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and γ-secretase independent redistribution. J Alzheimers Dis. 2010; 22(1):235-245. doi: 10.3233/JAD-2010-100585.

Lu Q, Ding K, Frosch MP, Jones S, Wolfe M, Xia W, Lanford GW. Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and γ-secretase independent redistribution. J Alzheimers Dis. 2010; 22(1):235-245. doi: 10.3233/JAD-2010-100585.

Wu, D., Raafat, A., Pak, E., Clemens, S. and Murashov, A.K. Dicer-­‐microRNA pathway is critical for peripheral nerve regeneration and functional recovery in vivo and regenerative axonogenesis in vitro. Exp Neurol. 2012; 233, 555-­‐565.

Friesland A, Zhao Y, Chen YH, Wang L, Zhou H, Lu Q. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc Natl Acad Sci U S A. 2013;110 (4):1261-6. doi: 10.1073/pnas.1116051110. Epub 2013; PMID: 23284167

S. K. Bareiss, M. Gwaltney, K. Hernandez, T. Lee, K. L Brewer. Excitotoxic spinal cord injury induced dysesthesias are associated with enhanced intrinsic growth of sensory neurons. Neuroscience Letters, 2013; 542:113-7. PMID 23500027.

Irene Hamrick, Razia Hafiz, and Doyle M. Cummings. Use of Days of the Week in a Modified Mini-Mental State Exam (M-MMSE) for Detecting Geriatric Cognitive Impairment. J Am Board Fam Med July-August 2013; 26:429-435; doi:10.3122/jabfm.2013.04.120300.

Lu Q, Aguilar BJ, Li M, Jiang Y, Chen YH. Genetic alterations of δ-catenin/NPRAP/Neurojungin (CTNND2): functional implications in complex human diseases. Hum Genet. 2016 Oct;135(10):1107-16. doi: 10.1007/s00439-016-1705-3. PMID: 27380241

Ghosh D, Curtis AD 2nd, Wilkinson DS, Mannie MD. Depletion of CD4+ CD25+ regulatory T cells confers susceptibility to experimental autoimmune encephalomyelitis (EAE) in GM-CSF-deficient Csf2-/- mice. J Leukoc Biol. 2016 Oct;100(4):747-760. PMID: 27256565

Wang D, Ghosh D, Islam SM, Moorman CD, Thomason AE, Wilkinson DS, Mannie MD.  IFN-β Facilitates Neuroantigen-Dependent Induction of CD25+ FOXP3+ Regulatory T Cells That Suppress Experimental Autoimmune Encephalomyelitis. J Immunol. 2016 Oct 15;197(8):2992-3007. PMID: 27619998.

Aguilar BJ, Zhou H, Lu Q. Cdc42 signaling pathway inhibition as a therapeutic target in Ras-related cancers. Curr Med Chem. 2017 Jun 1. doi: 10.2174/0929867324666170602082956. [Epub ahead of print] PMID: 28571533.

vonderEmbse AN, Hu Q, DeWitt JC. Developmental toxicant exposure in a mouse model of Alzheimer's disease induces differential sex-associated microglial activation and increased susceptibility to amyloid accumulation. J Dev Orig Health Dis. 2017 Aug;8(4):493-501. PMID: 28460650


Presentations supported by the Wooten Laboratory

S.K Bareiss, Q. Lu, T. E. Jones, T. Tran. Effects of Exercise Frequency on Blood Biomarker Profiles in a Triple-Transgenic Mouse Model of Alzheimer’s Disease. American Physical Therapy Association Combined Sections Meeting, Las Vegas, NV, February 2013.

T. Tran, Q. Lu, S.K. Bareiss. Effects of differential exercise training on hippocampal function using a triple-transgenic mouse model of Alzheimer’s disease. Society for Neuroscience, San Diego, CA, November 2013.

AN. vonderEmbse, C. Boles, Q. Hu, and J. C. DeWitt. Neurotoxicological disruption of microglial development and early vulnerabilities for Alzheimer’s disease. Society of Toxicology Annual Meeting and ToxExpo, San Diego CA. 2015.

AN. vonderEmbse and J. C. DeWitt. Wooten Update in the DeWitt lab’s research for Alzheimer’s disease. Alzheimer’s Association of Eastern North Carolina Neuse Region Meeting for Caregivers. 2015.

AN. vonderEmbse, C. Boles, D. Johnson, J. N. Franklin, Q. Hu, and J. C. DeWitt. Neurotoxicological disruption of microglial development and early vulnerabilities for Alzheimer’s disease. North Carolina Society of Toxicology Annual Meeting, Research Triangle Park NC. 2015.

B. J. Aguilar, B. Hinckley, S.Q. Huo, Y. H. Chen, and Q. Lu. The design and biological evaluation of novel Cdc42 inhibitors. 249th ACS National Meeting in Denver, Colorado. March, 2015.

AN. vonderEmbse, Q. Hu, and J. C. DeWitt. Developmental toxicant exposure and early neuroimmune susceptibilities for Alzheimer’s disease. Graduate Women in Science National Meeting, Raleigh NC. 2016.

AN. vonderEmbse, Q. Hu, and J.C. DeWitt. Developmental toxicant exposure and early neuroimmune susceptibilities for Alzheimer’s disease. Society of Toxicology Annual Meeting and ToxExpo, New Orleans LA. 2016.

Y. Zhu, GA Howard IV, K. Pittman, C. Boykin, KM Verbanac, and Q. Lu. The Therapeutic effect of Rho kinase inhibitor Y-27632 on suppression of tumor growth and protection of Chemotherapy-induced Peripheral Neuropathy (CIPN) in tumor-bearing CIPN mouse model. Society for Neuroscience, San Diego, CA, November 2016.

AN. vonderEmbse. Early vulnerabilities for Alzheimer’s disease. 2016. ECU Representative, 3 Minute Thesis (3MT) Regional Finalist, Conference for Southern Graduate Schools, Charlotte, NC. 2016

Y. Zhu, B. Aguilar, C. Boykin, T. Tran, and Q. Lu Re-evaluating Rho GTPase signaling as a potential therapeutic target for Alzheimer’s disease. Society for Neuroscience, Washington DC, November 2017