East Carolina Diabetes and Obesity Institute

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Hickner lab - website

(8/013/14)The Hickner Lab investigates areas of obesity, aging, exercise, nutrition, microvascular blood flow and lipolysis in skeletal muscle and adipose tissue. The areas of study have been diverse, encompassing exercise training and nutritional interventions across the lifespan, from prepubescent children to aged individuals. The studies have focused primarily on the regulation....

jon with awards - website

Jon Busada Receives Awards
(8/07/14)Recently, Dr. Chris Geyer and Jonathan Busada attended the Society for the Study of Reproduction conference in Grand Rapids, Michigan. Jon received the Lalor Foundation Merit Award and was named 1 of 6 finalist to compete in the Trainee Platform Competition. Jon presented a talk entitled "Retinoic acid (RA) Regulates Kit translation in Prospermatogonia in the Neonatal Testis: A Novel Non-genomic Mechanism of RA-regulated Gene Expression" and won second place in the competition.

Zeczycki Lab - website

(7/05/14)The Zeczycki Lab’s focuses on determining the mechanisms of catalysis and unraveling the complexities of allosteric regulation of those multifunctional enzymes that are important to the pathogenesis of disease states. Understanding the activity and regulation of these enzymes is critical for the development of effective...

houmard lab - website

(7/30/14)The Houmard Lab’s primary focus is examining how skeletal muscle metabolism is altered with conditions such as obesity, type 2 diabetes and the aging process, and how a physically active lifestyle can counteract decrements associated with these conditions. Current ongoing projects involve how fat oxidation is altered with obesity, the role ...

mcclung lab - website

(7/25/14)The McClung Lab is focused on understanding the molecular mechanisms of angiogenesis and vascular remodeling in both physiologic and pathologic processes, including: exercise, peripheral artery disease (PAD), atherosclerosis, cardiac and cerebral ischemia, diabetes, and cancer. The lab is interested in how genetic variation may direct the integration of individual cellular responses to ischemic insult, resulting in differential manifestations of tissue pathology in both pre-clinical models and in clinical patient populations...

brown lab - website

(7/16/14)The DB Laboratory is interested in developing new therapies for heart disease. The heart is the most metabolically active organ in the body, and our experiments seek to determine how the mitochondrial network sustains the energy supply necessary to support cardiac electromechanical function. During many pathological states, such as diabetes or following a heart attack, mitochondria don’t “breathe” as well as they do in the healthy state. We want to know what goes wrong, and if there are interventions that can improve...

cabot lab - website

(7/9/14)The Cabot Lab focuses on sphingolipid metabolism as it relates to cancer growth and therapy. Sphingolipid metabolism is an area of cancer research that has risen to clinical prominence over the last 15 years. This is because ceramide, the aliphatic backbone of sphingolipids, acts as a powerful tumor suppressor, whereas its glycosylated product, glucosylceramide, catalyzed by the enzyme glucosylceramide...
geyer lab - website
(7/1/14)The Geyer lab is interested in how retinoic acid (RA) directs the initial steps of male germ cell development. RA regulates the sex-specific timing of meiotic initiation in mice, which in males occurs at postnatal day (P)10. However, RA signaling initiates 1 week prior, at P3-4, yet we know almost nothing about the pathways or mechanisms initiated by RA signaling...
bridges - website
(6/25/14)The Bridges Lab is specifically interested in how Vitamin A (retinol) oxidative metabolites alter immune cell adhesion. Although the requirement of vitamin A in immunity has long been appreciated, only within the past three decades have the molecular mechanisms by which retinoids elicit their effects been elucidated. We are currently using various molecular and cellular tools to investigate the impact of retinoids on...
(6/18/14) There are still two available dates left for the upcoming fall Metabolism Joint Lab Meetings. The new permanent location will be LSB202 and the available dates left are: Oct. 23rd & 30th. Please contact Drew Rockett or Ashley Busada if you would like to claim one of these dates. Once all the dates have been claimed we will be sending out the schedule for the meetings.
jon award - website
Jon Busada receives Lalor Foundation Award
(4/18/14) Jon Busada recently received a 2014 Lalor Foundation Merit Award. In addition, Jon will compete as a finalist in the Society for the Study of Reproduction (SSR) Trainee Research Award competition. As a part of the competition, he will present a platform presentation at the SSR 2014 meeting in Grand Rapids, MI on July 22. Jon is a PhD student in the Anatomy & Cell Biology Department.
Lei - website
Lei Wang receives Research and Creative Achievement Award
(4/4/14) ECU Research and Creative Achievement Week (RCAW) provides students with an excellent opportunity to practice their presentation skills and meet other creative scholars at ECU with similar interests. Lei Wang presented a poster in the Biomedical Sciences category at this years RCAW and was the winner of the graduate poster presentations. Lei and her mentor Dr. Bridges were invited to attend the RCAW Awards Luncheon on Friday April 4 where she accepted her award.
(2/14/14) Article by Kathryn Kennedy, ECU News Services: “A new space for collaborative medical research and robotics training was lauded by East Carolina University officials this week as a visionary project at the heart of the university’s mission and talents. The fourth floor of the East Carolina Heart Institute at ECU officially opened Feb. 13 as part of the regular two-day Board of Trustees meeting. Board members, faculty and other guests toured the 37,000-square-foot space...
(11/25/13) Dr. Skip Cummings and colleagues are to be congratulated for being awarded a second grant from the Bristol-Myers Squibb Foundation in the amount of $450,000. The team will develop and implement a program to address the management of diabetes, depression, and distress. East Carolina was invited to submit this second proposal after achieving successful outcomes with its first...
(11/6/13) Dr. S. Raza Shaikh's lab has published a paper that appears on the cover of November 2013 issue of the Journal of Lipid Research. The article is entitled: “N-3 PUFAs enhance the frequency of murine B cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity.” Heather Teague, PhD student in the Department of Biochemistry and Molecular Biology is the first author on the paper...

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Welcome to the East Carolina Diabetes and Obesity Institute (ECDOI) at East Carolina University. The ECDOI is an interdisciplinary research institute jointly supported by the Divisions of Health Sciences and Research & Graduate Studies.

The ECDOI is well known for cutting-edge collaborative research in several fields related to disorders of metabolism, including bariatric surgery, muscle insulin signaling/glucose transport, bioenergetics/exercise physiology, and pediatric healthy weight programs.

The mission of the ECDOI is to promote and coordinate interdisciplinary basic and translational research programs in diabetes and obesity, to support the education and training of undergraduate, graduate and post-graduate students, and to foster the development of outreach prevention/treatment programs for the people of eastern North Carolina.

The ECDOI is comprised of more than 40 faculty members from 17 different departments on both the main and health sciences campus. The Institute is closely aligned with the East Carolina Heart Institute (ECHI) and offers ECDOI- and/or ECHI- affiliated faculty several research support programs, access to core equipment, and opportunities to forge new collaborations through a number of interactive research forums.

To find out more

Read more about the ECDOI and all about the research happening at the ECDOI. You can also find out more about how Diabetes and Obesity impacts NC.

Contact the ECDOI

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