Fluvial and lacustrine strata in the central Andes region record this intra-Cordilleran basin's Quaternary climate history. Our research documents the nature and timing of climate change as recorded in the terraced river valleys of the circum-Titicaca basin, the subsurface strata of the Rio Desaguadero valley and the Salar de Uyuni, and both surface and subsurface strata of the Salar de Uyuni, and Laguna Colorado and Verde. In addition, our collaboration with archeologists working in the region allows us to examine the relationships between changing climate and cultural history.